{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:11:03Z","timestamp":1777972263446,"version":"3.51.4"},"reference-count":83,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100014761","name":"Natural Science Foundation of Qingdao Municipality","doi-asserted-by":"publisher","award":["24-4-4-zrjj-157-jch"],"award-info":[{"award-number":["24-4-4-zrjj-157-jch"]}],"id":[{"id":"10.13039\/501100014761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241086"],"award-info":[{"award-number":["82241086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473674"],"award-info":[{"award-number":["82473674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004476","name":"Chinese Center for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2025-CKL-01"],"award-info":[{"award-number":["2025-CKL-01"]}],"id":[{"id":"10.13039\/501100004476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2026,5,5]]},"DOI":"10.1021\/acs.est.6c01412","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:00:46Z","timestamp":1776664846000},"page":"12838-12852","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Cascade Mechanistic Insights into Structure\u2013Activity Relationships for Quantitative Mode-of-Action Analysis: A Novel Risk Assessment Framework for OPFRs"],"prefix":"10.1021","volume":"60","author":[{"given":"Ze","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Occupational Health and Environmental Health, School of Public Health","place":["Qingdao, China"]},{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicong","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology","place":["Qingdao, China"]},{"name":"Shandong University","place":["Qingdao, China"]},{"name":"School of Water and Environment, Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Key Laboratory of Ecohydrology and Water Security in Arid and Semi-Arid Regions of Ministry of Water Resources","place":["Xi\u2019 an, China"]},{"name":"Chang\u2019 an University","place":["Xi\u2019 an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environmental Health, School of Public Health","place":["Qingdao, China"]},{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gan","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environmental Health, School of Public Health","place":["Qingdao, China"]},{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environmental Health, School of Public Health","place":["Qingdao, China"]},{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environmental Health, School of Public Health","place":["Qingdao, China"]},{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijie","family":"Sun","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuebin","family":"Lv","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5220-7009","authenticated-orcid":true,"given":"Guangbo","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology","place":["Beijing, China"]},{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"College of Resources and Environment","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences (UCAS)","place":["Beijing, China"]},{"name":"School of Environment","place":["Hangzhou, China"]},{"name":"Hangzhou Institute for Advanced Study, UCAS","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology","place":["Qingdao, China"]},{"name":"Shandong University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-8046","authenticated-orcid":true,"given":"Xiaoting","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environmental Health, School of Public Health","place":["Qingdao, China"]},{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environmental Health, School of Public Health","place":["Qingdao, China"]},{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-3917","authenticated-orcid":true,"given":"Guibin","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology","place":["Beijing, China"]},{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"College of Resources and Environment","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences (UCAS)","place":["Beijing, China"]},{"name":"School of Environment","place":["Hangzhou, China"]},{"name":"Hangzhou Institute for Advanced Study, UCAS","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2024.100612"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108092"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay6636"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax2054"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b07874"},{"key":"ref6\/cit6","volume-title":"Global and China Organophosphorus Flame Retardant Industry Research and Prospect Dynamic Analysis Report","author":"Institute C. C. E. R.","year":"2021"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132095"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.10.007"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115696"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c03824"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1289\/EHP6508"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c05970"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41512-2"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c06155"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800471"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1289\/EHP3264"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.08.020"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/20565623.2025.2483131"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.696892"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.130191"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.114120"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2025.02.003"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b02337"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s13040-016-0098-0"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/jat.4020"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134297"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18704-1"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.043"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00150"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408642"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.103983"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky092"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/envhealth.5c00014"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2022.115923"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01649-9"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2021.107830"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/envhealth.3c00099"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b02474"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105653"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00243-4"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c04046"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfac079"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202523469"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108025"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/es4029364"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39410-8"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900890116"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.04.007"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b06094"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00883-2"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.06.006"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.04.198"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14890"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-65595-z"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.109165"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20122874"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.01.065"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168557"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1039\/C8TX00005K"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4890"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2024.2382815"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-019-0383-2"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/envhealth.4c00240"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1289\/EHP184"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.08.012"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2023.10.002"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-019-09473-9"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103576"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107258"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113432"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.116541"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1080\/10934529.2016.1191819"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.3390\/toxics13040297"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.164823"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57024-0"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0210-7"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106803"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105698"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.135048"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2024.122262"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107291"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145375"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.126134"}],"container-title":["Environmental Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.6c01412","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.6c01412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:13:30Z","timestamp":1777968810000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.6c01412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":83,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,5,5]]}},"alternative-id":["10.1021\/acs.est.6c01412"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.6c01412","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}