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Here, we integrated exposure\u2013infection assays with controlled bioaerosol chamber experiments to quantitatively resolve differences between influenza A and B viruses across aerosolization and aging processes. By coupling these measurements with an effective inhaled dose model, we enabled strain-resolved comparisons of exposure potential as a function of host age and activity level. Our results show that strain-dependent differences in aerosolization efficiency, hygroscopic behavior, virion morphology, and physical stability cannot fully account for variations in airborne infectivity. Instead, biological inactivation during aerosol aging emerges as a key factor governing the loss of infectivity in airborne particles. Accordingly, A\/H3N2 maintains higher aerosol-phase infectivity across size ranges, whereas influenza B strains display more rapid loss of infectivity. Collectively, these findings identify aerosol-phase biological stability as a primary determinant of strain-specific airborne infectivity and provide a quantitative framework for assessing the aerosol exposure potential of emerging influenza variants and informing indoor respiratory health interventions.<\/jats:p>","DOI":"10.1021\/acs.est.6c01632","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:32:54Z","timestamp":1785853974000},"page":"22737-22747","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Simulation\nfor Identifying the Key Driver\nof Strain-Specific Airborne Infectivity of Influenza Viruses"],"prefix":"10.1021","volume":"60","author":[{"given":"Chunguang","family":"Yang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University , , ,","place":["Guangzhou, China, 510120"]},{"name":"Guangzhou National Laboratory , ,","place":["Guangzhou, China, 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510120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , ,","place":["Guangzhou, China, 510005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University , , ,","place":["Guangzhou, China, 510120"]},{"name":"Guangzhou National Laboratory , ,","place":["Guangzhou, China, 510005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Pan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University , , ,","place":["Guangzhou, China, 510120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University , , 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510120"]},{"name":"Guangzhou National Laboratory , ,","place":["Guangzhou, China, 510005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifeng","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University , , ,","place":["Guangzhou, China, 510120"]},{"name":"Guangzhou National Laboratory , ,","place":["Guangzhou, China, 510005"]},{"name":"Macau University of Science and Technology , , ,","place":["Macau SAR, China, 999078"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026081810412956500_cit1","volume-title":"Influenza Seasonal","author":"WHO.","year":"2025"},{"issue":"10127","key":"2026081810412956500_cit2","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0140-6736(17)33293-2","article-title":"Estimates of global\nseasonal influenza-associated respiratory mortality: a modelling 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Hazard. Mater"},{"key":"2026081810412956500_cit49","article-title":"Exposure\nFactors Handbook Chapter 6","volume-title":"Exposure Factors\nHandbook","author":"U.S. Environmental Protection Agency.","year":"2011"},{"issue":"5","key":"2026081810412956500_cit50","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/ina.12669","article-title":"Frequent recovery\nof influenza A but not influenza B virus RNA in aerosols in pediatric\npatient rooms","volume":"30","author":"Shiu","year":"2020","journal-title":"Indoor Air"},{"issue":"9","key":"2026081810412956500_cit51","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1021\/envhealth.5c00096","article-title":"Speaking Different\nLanguages Impacts Size-Resolved Exhaled Breath Aerosol Particle Emission","volume":"3","author":"Li","year":"2025","journal-title":"Environ. 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