{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:12:24Z","timestamp":1788437544445,"version":"build-2803163510"},"reference-count":84,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["2022-105"],"award-info":[{"award-number":["2022-105"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273679"],"award-info":[{"award-number":["82273679"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epidemiological evidence suggests that developmental arsenic (As) exposure increases behavioral abnormalities in offspring. However, how placental neuroendocrine function and sex-specific responses contribute to these effects remains poorly understood. Here, we demonstrate that maternal As exposure induces trophoblastic damage, vascular disruption, and placental labyrinth thinning, leading to placental dysplasia, fetal growth restriction, and sex-specific behavioral outcomes in offspring. Integrated transcriptomic and neurobehavioral analyses revealed sex-dependent alterations primarily involving neurodevelopmental pathways and transporter dysfunction. Concurrently, neurotransmitter metabolomic profiling identified profound disturbances in tryptophan, tyrosine, and amino acid metabolism in the placenta and fetal brain. Bayesian benchmark dose (BMD) modeling revealed that points of departure (PoDs) followed the rank order, such that metabolomic (mPoDs) &amp;lt; neurobehavioral (nPoDs) &amp;lt; apical (aPoDs). Notably, alterations in the tryptophan pathway were the most sensitive early perturbations observed, with BMDL10 values for 5-hydroxy-l-tryptophan of 3.73 \u03bcg\/L in females and 4.17 \u03bcg\/L in males, respectively. Overall, this exploratory framework provides evidence for placental neuroendocrine toxicity of As and highlights its potential relevance for refined environmental risk assessment.<\/jats:p>","DOI":"10.1021\/acs.est.6c02167","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:02:03Z","timestamp":1787047323000},"page":"23722-23735","source":"Crossref","is-referenced-by-count":0,"title":["Sex-Dependent Placental\nNeuroendocrine Disruption\nby Maternal Arsenic Exposure: From Neurotransmitter Dysregulation\nto Neurobehavioral Outcomes"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5000-8843","authenticated-orcid":true,"given":"Fang","family":"Chen","sequence":"first","affiliation":[{"name":"Guizhou Medical University , , ,","place":["Guiyang, China, 561113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"He","sequence":"additional","affiliation":[{"name":"Guizhou Medical University , , ,","place":["Guiyang, China, 561113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qin","sequence":"additional","affiliation":[{"name":"Guizhou Medical University , , ,","place":["Guiyang, China, 561113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6120-6075","authenticated-orcid":true,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Medical University , , ,","place":["Nanjing, China, 211166"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsong","family":"Tian","sequence":"additional","affiliation":[{"name":"Guizhou Medical University , , ,","place":["Guiyang, China, 561113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1138-8448","authenticated-orcid":true,"given":"Wenjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Guizhou Medical University , , ,","place":["Guiyang, China, 561113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7508-8583","authenticated-orcid":true,"given":"Aihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guizhou Medical University , , ,","place":["Guiyang, China, 561113"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"issue":"6493","key":"2026090307131322800_cit1","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1126\/science.abb9746","article-title":"Global Solutions\nto a Silent Poison","volume":"368","author":"Zheng","year":"2020","journal-title":"Science"},{"issue":"11","key":"2026090307131322800_cit2","doi-asserted-by":"publisher","first-page":"e513","DOI":"10.1016\/S2468-2667(17)30195-0","article-title":"The Effect\nof the Environmental Protection\nAgency Maximum Contaminant Level on Arsenic Exposure in the USA from\n2003 to 2014: An Analysis of the National Health and Nutrition Examination\nSurvey (NHANES)","volume":"2","author":"Nigra","year":"2017","journal-title":"Lancet Public Health"},{"issue":"6493","key":"2026090307131322800_cit3","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1126\/science.aba1510","article-title":"Global Threat of Arsenic in Groundwater","volume":"368","author":"Podgorski","year":"2020","journal-title":"Science"},{"issue":"2","key":"2026090307131322800_cit4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1097\/ede.0000000000000416","article-title":"Estimating\nEffects of Arsenic Exposure during Pregnancy on Perinatal Outcomes\nin a Bangladeshi Cohort","volume":"27","author":"Kile","year":"2016","journal-title":"Epidemiology"},{"issue":"5","key":"2026090307131322800_cit5","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1289\/ehp.1307894","article-title":"Association\nof Arsenic with Adverse Pregnancy Outcomes\/Infant Mortality: A Systematic\nReview and Meta-Analysis","volume":"123","author":"Quansah","year":"2015","journal-title":"Environ. 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Risk Assess.: Int. J."},{"key":"2026090307131322800_cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2024.122994","article-title":"Co-Occurrence\nof Arsenic and Sewage Pollutants in Surface and Groundwater and Its\nImplications for Water Treatment Using Membrane Technology","volume":"273","author":"de Aguilar","year":"2025","journal-title":"Water Res."},{"issue":"1","key":"2026090307131322800_cit30","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s10653-012-9460-4","article-title":"Arsenic Contamination:\nA Potential Hazard to the Affected Areas of West Bengal, India","volume":"35","author":"Rahaman","year":"2013","journal-title":"Environ. Geochem. 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