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In this study, the relative concentration-genotoxicity contributions of five groups of aliphatic DBPs (trihalomethanes, haloacetic acids (HAAs), haloacetonitriles, haloacetamides, and halonitromethanes) and seven groups of aromatic DBPs (halophenols, halohydroxybenzoic acids, halohydroxybenzaldehydes, halonitrophenols, halohydroxybenzonitriles, halophenylacetamides, and haloanilines) were analyzed according to the acquired concentration and genotoxicity data alongside the total ion current-toxicity potency (TIC-Tox) method. Notably, the comparative genotoxicity of aromatic DBPs was quantitatively evaluated for the first time, and the corresponding quantitative structure\u2013activity relationship model with satisfactory goodness-of-fit, robustness, and prediction performance was developed. Among these aromatic DBPs, halophenols were identified as possessing the highest genotoxicity. In both drinking water and wastewater effluents, aliphatic DBPs exhibited overwhelmingly higher relative concentration-genotoxicity contributions compared to aromatic DBPs. The genotoxicity forcing agents among aliphatic and aromatic DBPs in drinking water were identified as HAAs and haloanilines, respectively, which differed from the cytotoxicity forcing agents. In wastewater effluents, the genotoxicity forcing agents were identified as HAAs and halophenols, respectively. This work fills a critical knowledge gap regarding the genotoxicity forcing agents from individual DBPs in drinking water and wastewater effluents.<\/jats:p>","DOI":"10.1021\/acs.est.6c04014","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:01:56Z","timestamp":1786021316000},"page":"25716-25729","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Genotoxicity\nForcing Agents from Individual\nAliphatic and Aromatic Disinfection Byproducts in Drinking Water and\nWastewater Effluents"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-8185","authenticated-orcid":true,"given":"Shaoyang","family":"Hu","sequence":"first","affiliation":[{"name":"Shandong University, China-America CRC for Environment & Health , , ,","place":["Qingdao, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesong","family":"Ai","sequence":"additional","affiliation":[{"name":"Shandong University, China-America CRC for Environment & Health , , ,","place":["Qingdao, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Sun","sequence":"additional","affiliation":[{"name":"Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , , ,","place":["Hangzhou, China, 310024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong University, China-America CRC for Environment & Health , , ,","place":["Qingdao, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong University, China-America CRC for Environment & Health , , ,","place":["Qingdao, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4051-6312","authenticated-orcid":true,"given":"Zhigang","family":"Li","sequence":"additional","affiliation":[{"name":"Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , , ,","place":["Hangzhou, China, 310024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falin","family":"He","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-0531","authenticated-orcid":true,"given":"Rutao","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong University, China-America CRC for Environment & Health , , ,","place":["Qingdao, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"2026091511122521400_cit1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence,\ngenotoxicity, and carcinogenicity of regulated and emerging disinfection\nby-products in drinking water: A review and roadmap for research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. 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Pollut."},{"key":"2026091511122521400_cit45","doi-asserted-by":"publisher","first-page":"119458","DOI":"10.1016\/j.watres.2022.119458","article-title":"Comparative cytotoxicity,\nendocrine-disrupting effects, oxidative stress of halophenolic disinfection\nbyproducts and the underlying molecular mechanisms revealed by transcriptome\nanalysis","volume":"229","author":"Li","year":"2023","journal-title":"Water Res."},{"key":"2026091511122521400_cit46","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1021\/tx9601061","article-title":"Cytochrome\nP450-catalyzed oxidation of halobenzene derivatives","volume":"10","author":"Rietjens","year":"1997","journal-title":"Chem. Res. 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Technol."},{"key":"2026091511122521400_cit50","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1021\/acs.est.5c10449","article-title":"Immunotoxicity\nof disinfection byproducts\nand disinfected water: Sensitive assessment using impairment of macrophage\nanti-infection capacity as an end point","volume":"60","author":"Li","year":"2026","journal-title":"Environ.\nSci. 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