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We quantified 64 urinary CECs across seven chemical classes (bisphenol analogues, parabens, synthetic phenolic antioxidants, antimicrobials, organophosphate esters, neonicotinoids, and ultraviolet filters) and two oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostaglandin F2\u03b1 (8-isoPGF2\u03b1)] in 142 Chinese adults. Single-chemical associations were assessed using generalized linear models, while joint associations were evaluated by elastic net regression and quantile g-computation. By integrating leukocyte mRNA sequencing profiles, we identified redox-related transcriptional signatures linking CEC exposure to oxidative stress. Fourteen and 13 CECs were associated with elevated 8-OHdG and 8-isoPGF2\u03b1, respectively. Mixture analyses showed positive associations of combined CEC exposure with both biomarkers. Key contributors in mixture models included octabenzone, bisphenol A, tris(2-chloroisopropyl) phosphate, and acetamiprid for 8-OHdG and octabenzone, triisobutyl phosphate, and 2,6-di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dien-1-one for 8-isoPGF2\u03b1. Transcriptomic integration indicated mixture-associated oxidative stress was accompanied by coordinated redox-sensitive gene expression changes, with shared enrichment of inflammatory and stress-response pathways (including Toll-like receptor and MAPK signaling) across chemical classes. Notably, SYT1 and CCNP emerged as recurrent transcriptomic candidates linking CEC exposure with oxidative stress, supporting coordinated transcriptional response under real-world CEC coexposure.<\/jats:p>","DOI":"10.1021\/acs.est.6c04142","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:23:51Z","timestamp":1788323031000},"page":"25253-25267","source":"Crossref","is-referenced-by-count":0,"title":["Oxidative\nStress\nand Redox Transcriptomic Signatures\nAssociated with Coexposure to Emerging Contaminants"],"prefix":"10.1021","volume":"60","author":[{"given":"Zirui","family":"Zhang","sequence":"first","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Xu","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Cai","sequence":"additional","affiliation":[{"name":"Suzhou University of Science and Technology , , ,","place":["Suzhou, China, 215009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wending","family":"Li","sequence":"additional","affiliation":[{"name":"Columbia University Mailman School of Public Health , , , ,","place":["New York, New York, United States, 10032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]},{"name":"Yangtze University , , , ,","place":["Jingzhou, Hubei, China, 434023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2096-921X","authenticated-orcid":true,"given":"Meian","family":"He","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Guo","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-9578","authenticated-orcid":true,"given":"Tao","family":"Jing","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangchun","family":"Wu","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-7111","authenticated-orcid":true,"given":"Pinpin","family":"Long","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , , , ,","place":["Wuhan, Hubei, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"Suppl. 10","key":"2026091511110496700_cit1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1289\/ehp.94102s105","article-title":"Oxygen-Derived Species: Their Relation to Human Disease\nand Environmental Stress","volume":"102","author":"Halliwell","year":"1994","journal-title":"Environ. 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Chem."},{"key":"2026091511110496700_cit40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.envpol.2017.03.035","article-title":"Bioaccumulation\nand Biomagnification of Ultraviolet Absorbents in Marine Wildlife\nof the Pearl River Estuarine, South China Sea","volume":"225","author":"Peng","year":"2017","journal-title":"Environ. Pollut."},{"key":"2026091511110496700_cit41","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.toxlet.2023.05.006","article-title":"Benzophenone-Type\nUltraviolet Filters Inhibit Human and Rat Placental 3\u03b2-Hydroxysteroid\nDehydrogenases: Structure-Activity Relationship and in Silico Docking\nAnalysis","volume":"382","author":"Lin","year":"2023","journal-title":"Toxicol. 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