{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:42:01Z","timestamp":1792784521503,"version":"4.5.0"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"National Research Program for Key Issues in Air Pollution Control of China","award":["DQGG0401"],"award-info":[{"award-number":["DQGG0401"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82304222"],"award-info":[{"award-number":["82304222"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Youth Science Fund of the Chinese Center for Disease Control and Prevention","award":["2022YFC3702700"],"award-info":[{"award-number":["2022YFC3702700"]}],"id":[{"id":"https:\/\/ror.org\/04wktzw65","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Youth Science Fund of the Chinese Center for Disease Control and Prevention","award":["2023A205"],"award-info":[{"award-number":["2023A205"]}],"id":[{"id":"https:\/\/ror.org\/04wktzw65","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The cardiopulmonary risks of fine particulate matter (PM2.5) are linked to its constituents, yet key constituents and underlying molecular pathways driving cardiopulmonary dysfunctions in older adults remain elusive. In a longitudinal panel study of 313 measurements, we assessed associations between PM2.5 constituents and cardiopulmonary functions and explored mediation effects by DNA methylation and gene transcription using personal monitoring data. We combined a linear mixed-effects model with three machine-learning methods to identify key PM2.5 constituents, and employed mediation analysis and Ingenuity Pathway Analysis to explore potential epigenetic and transcriptional mediators and biological pathways. Our findings revealed that chloride ion (Cl\u2013), nickel (Ni), barium, and selenium were the key constituents of PM2.5 inducing cardiopulmonary dysfunction. Interquartile range (IQR) increases in Cl\u2013 and Ni were associated with a 3.48% (95% CI: 1.50%, 5.46%) increase in diastolic blood pressure and a 0.09% (95% CI: 0.05%, 0.12%) decrease in FEV1\/FVC, respectively. Mediation analysis identified 212 cytosine-phosphate-guanine (CpG) sites that regulated both cardiovascular and pulmonary dysfunctions, and 7 genes mediating more than two distinct constituent-function associations. Neurotransmission, metabolism, and cardiovascular function-related pathways were primarily enriched, among which 22 CpG sites (e.g., cg07115148, cg26409134, and cg26613778) were identified as key epigenetic mediators. Expression quantitative trait methylation analysis revealed that these CpG sites were associated with 14 protein-coding genes including CERS6 and LRCH3. Our findings suggest that short-term exposure to PM2.5 constituents triggers cardiopulmonary dysfunctions via DNA methylation-gene transcription axes and related disruption of neurotransmission, metabolism, and cardiovascular signaling pathways.<\/jats:p>","DOI":"10.1021\/acs.est.6c04206","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:01:38Z","timestamp":1789120898000},"page":"26073-26084","source":"Crossref","is-referenced-by-count":0,"title":["PM2.5 Constituents and Cardiopulmonary\nDysfunctions in Older Adults: A Multiomics Approach Unveiling Molecular\nPathways"],"prefix":"10.1021","volume":"60","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4716-390X","authenticated-orcid":true,"given":"Jianlong","family":"Fang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhan","family":"Zou","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Shandong University , , ,","place":["Jinan, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaonan","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilu","family":"Tong","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Queensland University of Technology , , ,","place":["Brisbane, Australia, 4006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-1422","authenticated-orcid":true,"given":"Song","family":"Tang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-571X","authenticated-orcid":true,"given":"Xiaoming","family":"Shi","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]},{"name":"Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100021"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"issue":"10440","key":"2026092210100662200_cit1","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/S0140-6736(24)00933-4","article-title":"Disease and Injury and Risk Factor Collaborators.\nGlobal Burden and Strength of Evidence for 88 Risk Factors in 204\nCountries and 811 Subnational Locations, 1990\u20132021: A Systematic\nAnalysis for the Global Burden of Disease Study 2021","volume":"403","author":"GBD.","year":"2024","journal-title":"Lancet"},{"issue":"3","key":"2026092210100662200_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(24)00003-2","article-title":"Estimates of Global\nMortality Burden Associated with Short-Term Exposure\nto Fine Particulate Matter 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Contaminant Metals as Cardiovascular\nRisk Factors: A Scientific Statement From the American Heart Association","volume":"12","author":"Lamas","year":"2023","journal-title":"JACC: Heart Failure"},{"issue":"1","key":"2026092210100662200_cit36","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00204-024-03903-2","article-title":"Heavy Metals:\nToxicity and Human Health Effects","volume":"99","author":"Jomova","year":"2025","journal-title":"Arch. Toxicol."},{"key":"2026092210100662200_cit37","doi-asserted-by":"publisher","first-page":"139801","DOI":"10.1016\/j.scitotenv.2020.139801","article-title":"The Relationship\nbetween Personal\nExposure and Ambient PM2.5 and Black Carbon in Beijing","volume":"737","author":"Lin","year":"2020","journal-title":"Sci. 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Hazard. Mater."},{"key":"2026092210100662200_cit41","doi-asserted-by":"publisher","first-page":"138547","DOI":"10.1016\/j.jhazmat.2025.138547","article-title":"Solubilities and Sources of PM2.5-Associated\nHazardous Elements in the Megacity of Beijing, China","volume":"494","author":"Xu","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"2026092210100662200_cit42","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1186\/s12967-025-06538-8","article-title":"Heavy Metals and Their Relationships\nwith Lung Function and Airway Inflammation: Insights from a Population-Based\nStudy","volume":"23","author":"Jin","year":"2025","journal-title":"J. Transl. 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