{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:42:43Z","timestamp":1792784563330,"version":"4.5.0"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"European Union?s Horizon Europe research and innovation programme","award":["101057014"],"award-info":[{"award-number":["101057014"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early-life chemical exposures may contribute to adverse health outcomes later in life. However, conventional chemical analyses typically cover only a limited subset of the chemical exposureome. Suspect and nontargeted screening (SS\/NTS) using high-resolution mass spectrometry (HRMS) workflows provides a powerful framework for comprehensive assessments of exposure, with the potential to detect a broad range of environmental contaminants and emerging chemicals. An interlaboratory assay involving 12 laboratories was performed to evaluate the comparability and complementarity of SS\/NTS approaches for maternal urine, serum, and milk, based on reversed-phase (RPLC), hydrophilic interaction liquid chromatography (HILIC), and gas chromatography (GC) with HRMS. Participants used in-house methods to possibly detect a predefined and shared list of 50 compounds with varying polarities spiked at three concentrations. The overall detection rates ranged from 4% to 72% for all three techniques, with RPLC-HRMS covering compounds with log\u202fP 0\u20136, while HILIC-HRMS and GC-HRMS extended this coverage. Univariate and multivariable analyses of RPLC-HRMS results for serum and urine identified sample preparation steps as key factors influencing detection rates. Workflow performances were additionally benchmarked by using the S-score. These findings demonstrate the complementarity of SS\/NTS platforms for extending chemical-space coverage for the most comprehensive exposure characterization. Therefore, efforts should be made for harmonized QA\/QC provisions while conserving the added value of different workflows for exposure data for risk assessments.<\/jats:p>","DOI":"10.1021\/acs.est.6c04347","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:01:53Z","timestamp":1789477313000},"page":"26987-27000","source":"Crossref","is-referenced-by-count":0,"title":["Comparing Suspect\nand Nontargeted Screening Workflows\nfor Perinatal Chemical Exposome Analysis: A European Interlaboratory\nStudy from the PARC-EU Project"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-9868","authenticated-orcid":true,"given":"Tarek","family":"Moufawad","sequence":"first","affiliation":[{"name":"Oniris, INRAE, LABERCA , ,","place":["Nantes, France, 44300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolawole","family":"Ayeni","sequence":"additional","affiliation":[{"name":"University of Vienna , , ,","place":["Vienna, Austria, 1090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Baira","sequence":"additional","affiliation":[{"name":"Benaki Phytopathological Institute , , , ,","place":["Kifissia, Attica, Greece, 145 61"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Baudry","sequence":"additional","affiliation":[{"name":"Ploufragan-Plouzane\u0301-Niort Laboratory, Ruminant Diseases and Welfare Unit , , 60 Rue Pied de Fond 28440 , ,","place":["Niort, CS, France, 79024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7147-384X","authenticated-orcid":true,"given":"Lidia","family":"Belova","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Wilrijk, ,","place":["Antwerp, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Chaker","sequence":"additional","affiliation":[{"name":"Univ Rennes , , ,","place":["Rennes, France, 35000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Chalet","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris-Saclay , , ,","place":["Gif Sur Yvette, France, 91191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-1136","authenticated-orcid":true,"given":"Adrian","family":"Covaci","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Wilrijk, ,","place":["Antwerp, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4075-5187","authenticated-orcid":true,"given":"Annelaure","family":"Damont","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris-Saclay , , ,","place":["Gif Sur Yvette, France, 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