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Decabromodiphenyl ethane (DBDPE) is a novel brominated flame retardant that can accumulate in the liver. Given the widespread environmental distribution of DBDPE and rising burden of alcohol abuse, this study investigated the impact of DBDPE on alcoholic liver injury progression by preexposing male zebrafish to DBDPE followed by an acute ethanol challenge. The results showed that DBDPE induced tissue damage and lipid accumulation, which correlated with mitochondrial dysfunction and oxidative stress. DBDPE pre-exposure significantly impaired recovery from ethanol-induced liver injury, as evidenced by delayed normalization of serum transaminase activities. Single-cell transcriptomics further revealed that DBDPE disrupted the tight junction pathway in cholangiocytes and suppressed alcohol metabolism-related pathways in hepatocytes, which correlated with subsequent cholestasis and impaired liver recovery after alcohol challenge. Notably, these adverse effects were driven by NAD+ deficiency, as supplementation with nicotinamide riboside to restore NAD+ levels effectively mitigated DBDPE-induced impairments. Our findings suggest that DBDPE increases zebrafish susceptibility to and impedes recovery from alcoholic liver injury through NAD+ suppression, identifying it as an environmental risk factor for the progression of alcoholic liver disease.<\/jats:p>","DOI":"10.1021\/acs.est.6c05329","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:02:52Z","timestamp":1785852172000},"page":"21569-21581","source":"Crossref","is-referenced-by-count":0,"title":["Decabromodiphenyl\nEthane Sensitizes Zebrafish to Alcoholic\nLiver Injury by Compromising NAD+-Mediated Multicellular\nResponses"],"prefix":"10.1021","volume":"60","author":[{"given":"Fan","family":"Li","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Wuhan, China, 430072"]},{"name":"Henan Normal University , , ,","place":["Xinxiang, China, 453007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-0610","authenticated-orcid":true,"given":"Lihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Wuhan, China, 430072"]},{"name":"Huazhong Agricultural University , , ,","place":["Wuhan, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yindan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Wuhan, China, 430072"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Fu","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9453-6779","authenticated-orcid":true,"given":"Yuxi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna","family":"Han","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , ,","place":["Shanghai, China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6322-2597","authenticated-orcid":true,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , ,","place":["Shanghai, China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-0003","authenticated-orcid":true,"given":"Jian","family":"Han","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-1868","authenticated-orcid":true,"given":"Bingsheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"2026081110100312400_cit1","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1016\/j.cgh.2019.07.060","article-title":"Contemporary epidemiology of chronic\nliver disease and cirrhosis","volume":"18","author":"Moon","year":"2020","journal-title":"Clin. 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