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This study comparatively examined the occurrence, biomagnification, and associations between 103 HOCs and 36 FAs in two predator-based food webs from the Pearl River Estuary: a marine fish\u2013dolphin (Sousa chinensis) food web and a mangrove-associated terrestrial insect\u2013spider (Nephila pilipes) food web. The fish\u2013dolphin food web exhibited higher HOC biomagnification (BMFs &amp;lt; 489) and trophic magnification (TMFs &amp;lt; 5.19) than the insect\u2013spider food web (BMFs &amp;lt; 2.78; TMFs &amp;lt; 3.08), although both showed similar biomagnification peaks at log KOW \u2248 7 and log KOA \u2248 11. Multivariate analyses identified 2,2\u2032,4,4\u2032,5,5\u2032-hexachlorobiphenyl (PCB-153), 2,2\u2032,4,4\u2032-tetrabromodiphenyl ether (BDE-47), and a medium-chain chlorinated paraffin congener (C17H29Cl7) as contaminants most strongly associated with dolphin FA profiles, whereas 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl)-tetrabromophthalate (TBPH), and 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p\u2032-DDT) were predominant contributors in spiders. HOC concentrations showed positive associations with saturated FAs in dolphins but negative associations with polyunsaturated FAs in spiders, and were significantly associated with FA-derived metabolic indices (R2 = 0.234\u20130.554, p &amp;lt; 0.05), including stearoyl-CoA desaturase 16 (SCD16) and stearoyl-CoA desaturase 18 (SCD18) in dolphins, and delta-6-desaturase (D6D) and de novo lipogenesis (DNL) in spiders. These relationships are correlative and likely reflect the combined influence of food-web characteristics, contaminant exposure, and species-specific physiology. This study provides a comparative assessment of HOC biomagnification and FA-derived metabolic indicators across contrasting predator-based coastal food webs.<\/jats:p>","DOI":"10.1021\/acs.est.6c06025","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:32:28Z","timestamp":1788417148000},"page":"25741-25752","source":"Crossref","is-referenced-by-count":0,"title":["Fatty Acid-Derived\nMetabolic Indicators and Biomagnification\nof Halogenated Organic Contaminants: A Comparative Analysis of Adjacent\nCoastal Predator-Based Food Webs"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-5223","authenticated-orcid":true,"given":"Qiang","family":"Xie","sequence":"first","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Guangzhou, China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-3396","authenticated-orcid":true,"given":"Lihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Zhuhai, China, 519082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lvyan","family":"Tan","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Guangzhou, China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3411-3954","authenticated-orcid":true,"given":"Siqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Zhuhai, China, 519082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Guangzhou, China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congmo","family":"Jin","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Zhuhai, China, 519082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglong","family":"Jia","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Guangzhou, China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5603-3042","authenticated-orcid":true,"given":"Yuping","family":"Wu","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Zhuhai, China, 519082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-8282","authenticated-orcid":true,"given":"Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Guangzhou, China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Zhuhai, China, 519082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1546-0902","authenticated-orcid":true,"given":"Tiangang","family":"Luan","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , ,","place":["Guangzhou, China, 510275"]},{"name":"Wuyi University , , ,","place":["Jiangmen, China, 529020"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"11","key":"2026091511113592300_cit1","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1007\/s00018-018-2765-4","article-title":"Lipids in the cell: organisation regulates function","volume":"75","author":"Santos","year":"2018","journal-title":"Cell. 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Hazard.\nMater."},{"issue":"2","key":"2026091511113592300_cit4","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/gcb.15387","article-title":"Increasing\ntemperature and productivity\nchange biomass, trophic pyramids and community-level omega-3 fatty\nacid content in subarctic lake food webs","volume":"27","author":"Keva","year":"2021","journal-title":"Global\nChange Biol."},{"key":"2026091511113592300_cit5","doi-asserted-by":"publisher","first-page":"139907","DOI":"10.1016\/j.scitotenv.2020.139907","article-title":"Fatty acids as dietary\nbiomarkers in mangrove ecosystems: Current status and future perspective","volume":"739","author":"Guo","year":"2020","journal-title":"Sci. Total Environ."},{"key":"2026091511113592300_cit6","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.2147\/DMSO.S264851","article-title":"Understanding the multiple\neffects of PCBs on lipid metabolism","volume":"13","author":"Shan","year":"2020","journal-title":"Diabetes,\nMetab. Synd. 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Pollut."},{"key":"2026091511113592300_cit21","doi-asserted-by":"publisher","first-page":"124424","DOI":"10.1016\/j.jhazmat.2020.124424","article-title":"Trophic transfer of emerging metallic contaminants\nin a neotropical mangrove ecosystem food web","volume":"408","author":"Souza","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"2026091511113592300_cit22","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1071\/IS05016","article-title":"The systematics\nand biology of the\nspider genus Nephila (Araneae: Nephilidae) in the\nAustralasian region","volume":"21","author":"Harvey","year":"2007","journal-title":"Invertebr. 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Manage."},{"key":"2026091511113592300_cit27","doi-asserted-by":"publisher","first-page":"112747","DOI":"10.1016\/j.ecoenv.2021.112747","article-title":"Metal pollution in\nthe Pearl River Estuary and implications for estuary\nmanagement: The influence of hydrological connectivity associated\nwith estuarine mixing","volume":"225","author":"Niu","year":"2021","journal-title":"Ecotoxicol. Environ.\nSaf."},{"key":"2026091511113592300_cit28","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-3-662-61834-9_3","article-title":"Pollution in\nthe Pearl River Estuary","volume-title":"Environmental\nPollution of the Pearl River Estuary, China","author":"Wang","year":"2020"},{"key":"2026091511113592300_cit29","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.envint.2019.03.036","article-title":"Biomagnification of\nPBDEs and alternative brominated flame retardants in a predatory fish:\nUsing fatty acid signature as a primer","volume":"127","author":"Tao","year":"2019","journal-title":"Environ.\nInt."},{"issue":"27","key":"2026091511113592300_cit30","doi-asserted-by":"publisher","first-page":"13970","DOI":"10.1021\/acs.est.5c00313","article-title":"Spider Webs as Noninvasive Indicators\nof Biomagnification and Tissue Partitioning of Halogenated Organic\nContaminants in Mangrove Ecosystems","volume":"59","author":"Xie","year":"2025","journal-title":"Environ.\nSci. 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Stat."},{"issue":"22","key":"2026091511113592300_cit39","doi-asserted-by":"publisher","first-page":"13246","DOI":"10.1021\/acs.est.9b05891","article-title":"Biological traits\nand the transfer of persistent organic pollutants through river food\nwebs","volume":"53","author":"Windsor","year":"2019","journal-title":"Environ. Sci. 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Total Environ."},{"key":"2026091511113592300_cit43","volume-title":"Biology of spiders","author":"Foelix","year":"2011"},{"key":"2026091511113592300_cit44","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.envpol.2015.03.041","article-title":"Bioaccumulation and biomagnification\nof classical flame retardants, related halogenated natural compounds\nand alternative flame retardants in three delphinids from Southern\nEuropean waters","volume":"203","author":"Baro\u0301n","year":"2015","journal-title":"Environ. Pollut."},{"issue":"22","key":"2026091511113592300_cit45","doi-asserted-by":"publisher","first-page":"13523","DOI":"10.1021\/acs.est.8b04240","article-title":"Persistent organic\npollutant burden, experimental POP\nexposure, and tissue properties affect metabolic profiles of blubber\nfrom gray seal pups","volume":"52","author":"Robinson","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"2026091511113592300_cit46","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s11745-016-4196-z","article-title":"Fatty acid composition\nof tropical fish depends on reservoir trophic status and fish feeding\nhabit","volume":"51","author":"Gomes","year":"2016","journal-title":"Lipids"},{"issue":"18","key":"2026091511113592300_cit47","doi-asserted-by":"publisher","first-page":"11282","DOI":"10.1021\/acs.est.0c03096","article-title":"Trophic magnification\nof short- and medium-chain chlorinated paraffins\nin terrestrial food webs and their bioamplification in insects and\namphibians during metamorphosis","volume":"54","author":"Liu","year":"2020","journal-title":"Environ. 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