{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:52:33Z","timestamp":1787071953126,"version":"build-2736575974"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"National Institute of Environmental Research (NIER), Ministry of Climate, Energy and Environment, Republic of Korea","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prenatal methylmercury (MeHg) exposure drives neurodevelopmental impairment in East Asia, but existing physiologically based pharmacokinetic (PBPK) models rely on population-average parameters and single-matrix validation. We developed a three-submodel mixed-effects PBPK (MEM-PBPK) framework validated against maternal blood, cord blood, urinary, and breast milk mercury in two Korean birth cohorts (Ko-CHENS, n = 3,625; NOEMOC, n = 242). Clinical chemistry-individualized Michaelis\u2013Menten placental kinetics reproduced second-trimester blood mercury (mean fold error, MFE = 0.946); empirical Bayes random effects improved cord blood prediction to MFE = 0.954 (within-2-fold = 100%). Biomarker bridging replicated +38.7% raw and \u221232.6% creatinine-corrected urinary trimester changes (p &amp;lt; 0.001), and breast milk MFE = 1.057. Critically, postnatal glomerular filtration maturation prolonged neonatal inorganic mercury renal half-life \u223c5-fold (\u223c160 d at birth vs \u223c32 d in adults; partial rank correlation coefficient, PRCC &amp;gt; 0.99) without affecting blood MeHg, demonstrating that blood-only biomonitoring systematically underestimates neonatal kidney mercury burden. These findings support cord-blood-anchored multimatrix biomonitoring and postnatal urinary iHg surveillance in East Asian populations.<\/jats:p>","DOI":"10.1021\/acs.est.6c06050","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:04:45Z","timestamp":1786025085000},"page":"22256-22273","source":"Crossref","is-referenced-by-count":0,"title":["Mixed-Effects\nPhysiologically Based Pharmacokinetic\nModeling of Methylmercury across the Maternal\u2013Infant Continuum:\nMulti-Matrix Evaluation in Two Korean Birth Cohorts"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-7244","authenticated-orcid":true,"given":"Ju Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Kyung Hee University , , 26 Kyungheedae-ro , Dongdaemun-gu, ,","place":["Seoul, Republic of Korea, 02447"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hi Gyu","family":"Moon","sequence":"additional","affiliation":[{"name":"Korea Institute of Toxicology , , 17 Jegok-gil , Munsan-eup, , ,","place":["Jinju-si, Gyeongsangnam-do, Republic of Korea, 52834"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Ko-CHENS Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"issue":"10","key":"2026081810413359500_cit1","doi-asserted-by":"publisher","first-page":"4967","DOI":"10.1021\/es305071v","article-title":"Mercury as\na global pollutant: sources, pathways, and effects","volume":"47","author":"Driscoll","year":"2013","journal-title":"Environ. 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