{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:27:05Z","timestamp":1787074025922,"version":"build-2736575974"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22225601"],"award-info":[{"award-number":["22225601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD1203302"],"award-info":[{"award-number":["2025ZD1203302"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Carbohydrates with high structural complexity are involved in key biological processes and serve as susceptible targets of environmental metabolic disruptors. However, the lack of a high-throughput and sensitive method for profiling carbohydrates limits our mechanistic understanding of the disruption of sugar metabolic pathways. In this study, we found that postcolumn addition of 10 \u03bcM (chloromethyl)triphenylphosphonium chloride (Ph3(CH2Cl)PCl) enabled the efficient ionization of saccharides and sugar alcohols as [M+Cl]\u2212 adducts in high-resolution mass spectrometry analysis, lowering instrumental detection limits by an average of 4- to 767-fold. A nontargeted method for polyol-containing compounds (PCCs) was subsequently established by leveraging their characteristic chlorinated isotope patterns. Approximately 68 PCCs, including saccharides with a degree of polymerization of 1\u201315, sugar alcohols, nonglucosyl saccharides, O-glycosides, nucleosides, amino sugars, a purine base, and a vitamin, were identified from microbially rich samples such as beer and mouse cecal contents. The method successfully identified disrupted saccharides and nucleosides in the cecal contents of mice exposed to a bisphenol A replacement (TGSA). Ph3(CH2Cl)PCl-enhanced ionization was further found to enhance analytical sensitivity and expand the species coverage in mass spectrum imaging, broadening the range of detectable saccharides (e.g., di- and trisaccharides) in biological samples. The imaging method confirmed alterations of PCCs in the central nervous system and liver tissues by medium-chain chlorinated paraffins during fetal development. This study provides an effective tool for the quantification, identification, and imaging of PCCs to screen for environmental disruptors of sugar metabolism.<\/jats:p>","DOI":"10.1021\/acs.est.6c07130","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:35:07Z","timestamp":1785854107000},"page":"22287-22298","source":"Crossref","is-referenced-by-count":0,"title":["Phosphonium\nChloride-Enhanced\nIonization for High-Throughput\nScreening and Imaging of Carbohydrate Metabolites: Unveiling Disruptors\nof Sugar Metabolism"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4944-5901","authenticated-orcid":true,"given":"Wenyi","family":"Li","sequence":"first","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Jiao","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Shang","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Tian","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqi","family":"Sun","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-6254","authenticated-orcid":true,"given":"Yi","family":"Wan","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100871"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"12","key":"2026081810392179500_cit1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207951","article-title":"Benefits\nof resistance\ntraining on body composition and glucose clearance are inhibited by\nlong-term low carbohydrate diet in rats","volume":"13","author":"Bader","year":"2018","journal-title":"PLoS\nOne"},{"key":"2026081810392179500_cit2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.biortech.2019.03.014","article-title":"Study of\nan enhanced dry anaerobic digestion of swine manure: Performance and\nmicrobial community property","volume":"282","author":"Hu","year":"2019","journal-title":"Bioresour. Technol."},{"key":"2026081810392179500_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2021.122336","article-title":"LC-MS\/MS-based\nnon-isotopically paired labeling (NIPL) strategy for\nthe qualification and quantification of monosaccharides","volume":"231","author":"Qu","year":"2021","journal-title":"Talanta"},{"issue":"18","key":"2026081810392179500_cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26188979","article-title":"Environmental Insults\nto Glucose Metabolism: The Role of Pollutants in Insulin Resistance","volume":"26","author":"M\u0142ynarska","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"2026081810392179500_cit5","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.envpol.2019.01.118","article-title":"Metabolomics analysis of a mouse model for chronic exposure to ambient\nPM2.5","volume":"247","author":"Xu","year":"2019","journal-title":"Environ. Pollut."},{"issue":"12","key":"2026081810392179500_cit6","doi-asserted-by":"publisher","first-page":"8851","DOI":"10.1021\/acs.analchem.5c04230","article-title":"A Sugaromics\nMethod for Combined Targeted and Untargeted Sugar Profiling: Fit-for-Purpose\nValidation of a Quantitative GC \u00d7 GC-MS Approach","volume":"98","author":"Streitenberger","year":"2026","journal-title":"Anal. Chem."},{"key":"2026081810392179500_cit7","doi-asserted-by":"publisher","first-page":"11073","DOI":"10.2147\/DDDT.S561012","article-title":"Analytical\nStrategies for Natural Mono- and Disaccharide Isomer Differentiation:\nTechniques and Applications","volume":"19","author":"Yang","year":"2025","journal-title":"Drug Des. Dev.\nTher."},{"issue":"24","key":"2026081810392179500_cit8","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.1039\/D5AN00937E","article-title":"Toward minimally invasive metabolomics:\nGC-MS metabolic fingerprints of dried blood microsamples in comparison\nto plasma","volume":"150","author":"Silva","year":"2025","journal-title":"Analyst"},{"issue":"10","key":"2026081810392179500_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102445","article-title":"GC \u00d7 GC-TOFMS metabolomics analysis\nidentifies elevated levels of plasma sugars and sugar alcohols in\ndiabetic mellitus patients with kidney failure","volume":"298","author":"Duangkumpha","year":"2022","journal-title":"J. Biol. Chem."},{"key":"2026081810392179500_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2020.122370","article-title":"Simultaneous analysis of monosaccharides\nusing ultra high performance liquid chromatography-high resolution\nmass spectrometry without derivatization for validation of certified\nreference materials","volume":"1160","author":"Han","year":"2020","journal-title":"J. Chromatogr. B"},{"issue":"6","key":"2026081810392179500_cit11","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1093\/ajcn\/nqac286","article-title":"A red wine intervention does not\nmodify plasma trimethylamine\nN-oxide but is associated with broad shifts in the plasma metabolome\nand gut microbiota composition","volume":"116","author":"Haas","year":"2022","journal-title":"Am. J. Clin.\nNutr."},{"issue":"6","key":"2026081810392179500_cit12","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/clinchem\/hvae043","article-title":"Ultra-Performance Liquid Chromatography\u2013Tandem\nMass Spectrometry Analysis of Urinary Oligosaccharides and Glycoamino\nAcids for the Diagnosis of Mucopolysaccharidosis and Glycoproteinosis","volume":"70","author":"Wongkittichote","year":"2024","journal-title":"Clin. Chem."},{"issue":"8","key":"2026081810392179500_cit13","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1021\/acs.analchem.1c04924","article-title":"Paired\nDerivatization Approach with H\/D-Labeled Hydroxylamine Reagents for\nSensitive and Accurate Analysis of Monosaccharides by Liquid Chromatography\nTandem Mass Spectrometry","volume":"94","author":"Wang","year":"2022","journal-title":"Anal. Chem."},{"issue":"4","key":"2026081810392179500_cit14","doi-asserted-by":"publisher","DOI":"10.3390\/nu15040888","article-title":"Comparative Analysis of Oligosaccharides\nin Breast Milk and Feces of Breast-Fed Infants by Using LC-QE-HF-MS:\nA Communication","volume":"15","author":"Li","year":"2023","journal-title":"Nutrients"},{"issue":"13","key":"2026081810392179500_cit15","doi-asserted-by":"publisher","first-page":"3334","DOI":"10.1073\/pnas.1700677114","article-title":"Diagnosis of prostate cancer by desorption\nelectrospray ionization mass spectrometric imaging of small metabolites\nand lipids","volume":"114","author":"Banerjee","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"2026081810392179500_cit16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27031446","article-title":"Quantitative Measurement of Hexoses by Betaine Aldehyde\nDerivatisation","volume":"27","author":"Kret-Bu\u0142at","year":"2026","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"2026081810392179500_cit17","doi-asserted-by":"publisher","DOI":"10.1289\/EHP11896","article-title":"Association between\nOrganophosphate\nEster Exposure and Insulin Resistance with Glycometabolic Disorders\namong Older Chinese Adults 60\u201369 Years of Age: Evidence from\nthe China BAPE Study","volume":"131","author":"Ding","year":"2023","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"2026081810392179500_cit18","doi-asserted-by":"publisher","DOI":"10.1289\/EHP9688","article-title":"PM2.5 and\nSerum Metabolome and Insulin Resistance,\nPotential Mediation by the Gut Microbiome: A Population-Based Panel\nStudy of Older Adults in China","volume":"130","author":"Zhao","year":"2022","journal-title":"Environ. Health\nPerspect."},{"issue":"1","key":"2026081810392179500_cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67709-9","article-title":"Developmental\nexposure of California mice to endocrine disrupting chemicals and\npotential effects on the microbiome-gut-brain axis at adulthood","volume":"10","author":"Kaur","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"2026081810392179500_cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57158-z","article-title":"Air pollution exposure\nmay impact the composition of human milk oligosaccharides","volume":"14","author":"Naik","year":"2024","journal-title":"Sci. Rep."},{"issue":"12","key":"2026081810392179500_cit21","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26123669","article-title":"Development and Optimisation of HILIC-LC-MS Method for Determination\nof Carbohydrates in Fermentation Samples","volume":"26","author":"Pismenno\u0303i","year":"2021","journal-title":"Molecules"},{"issue":"19","key":"2026081810392179500_cit22","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1016\/j.jchromb.2011.03.044","article-title":"Highly sensitive, quick\nand simple quantification method for mono and disaccharides in aqueous\nmedia using liquid chromatography\u2013atmospheric pressure chemical\nionization\u2013mass spectrometry (LC\u2013APCI\u2013MS)","volume":"879","author":"Ricochon","year":"2011","journal-title":"J. Chromatogr. B"},{"issue":"18","key":"2026081810392179500_cit23","doi-asserted-by":"publisher","first-page":"5453","DOI":"10.1007\/s00216-015-8717-z","article-title":"Separation of monosaccharides hydrolyzed\nfrom glycoproteins without the need for derivatization","volume":"407","author":"Lowenthal","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"issue":"7","key":"2026081810392179500_cit24","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1021\/es062390g","article-title":"Analysis of Sugars\nand Sugar Polyols in Atmospheric\nAerosols by Chloride Attachment in Liquid Chromatography\/Negative\nIon Electrospray Mass Spectrometry","volume":"41","author":"Wan","year":"2007","journal-title":"Environ.\nSci. Technol."},{"key":"2026081810392179500_cit25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.carres.2018.08.007","article-title":"Quantitation of carbohydrate monomers\nand dimers by liquid chromatography coupled with high-resolution mass\nspectrometry","volume":"468","author":"Barzen-Hanson","year":"2018","journal-title":"Carbohydr. Res."},{"issue":"20","key":"2026081810392179500_cit26","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.1007\/s00216-025-05988-9","article-title":"Liquid\nchromatography-mass spectrometry approach for characterizing sucrose\nisomers in complex mono-floral honey","volume":"417","author":"Amoah","year":"2025","journal-title":"Anal.\nBioanal. Chem."},{"key":"2026081810392179500_cit27","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.foodchem.2014.12.035","article-title":"Simultaneous\ndetermination of monosaccharides and oligosaccharides\nin dates using liquid chromatography\u2013electrospray ionization\nmass spectrometry","volume":"176","author":"Ghfar","year":"2015","journal-title":"Food Chem."},{"issue":"1\u20132","key":"2026081810392179500_cit28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.chroma.2008.02.010","article-title":"Analysis of\ncarbohydrates in Lupinus albus stems on\nimposition of water deficit, using porous graphitic carbon liquid\nchromatography-electrospray ionization mass spectrometry","volume":"1187","author":"Antonio","year":"2008","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"2026081810392179500_cit29","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/(SICI)1096-9888(200003)35:3&lt;378::AID-JMS945&gt;3.0.CO;2-M","article-title":"Quantitative\ndetermination of?-cyclodextrin in human plasma by liquid chromatography\/positive\nion electrospray mass spectrometry","volume":"35","author":"Hammes","year":"2000","journal-title":"J. Mass\nSpectrom."},{"issue":"3","key":"2026081810392179500_cit30","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27031138","article-title":"The Biological Fate of Pharmaceutical\nExcipient \u03b2-Cyclodextrin: Pharmacokinetics, Tissue Distribution,\nExcretion, and Metabolism of \u03b2-Cyclodextrin in Rats","volume":"27","author":"Mu","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"2026081810392179500_cit31","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1021\/acsfoodscitech.3c00641","article-title":"Combined\nAlcohol Soluble Carbohydrate Determination (CASCADE) of Food","volume":"4","author":"Cheang","year":"2024","journal-title":"ACS Food Sci. Technol."},{"issue":"1","key":"2026081810392179500_cit32","doi-asserted-by":"publisher","DOI":"10.1186\/2047-217X-2-13","article-title":"The role\nof reporting standards for metabolite annotation and identification\nin metabolomic studies","volume":"2","author":"Salek","year":"2013","journal-title":"GigaScience"},{"key":"2026081810392179500_cit33","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1039\/D5AY01489A","article-title":"The analysis of 80 simple saccharides\nby ion chromatography\nmass spectrometry","volume":"18","author":"Yates","year":"2026","journal-title":"Anal. Methods"},{"key":"2026081810392179500_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2020.122498","article-title":"An UPLC-MS\/MS\nmethod for quantification of D-pinitol in rat plasma and its application\nto a pharmacokinetic and bioavailability study","volume":"1163","author":"Qiu","year":"2021","journal-title":"J. Chromatogr. B"},{"issue":"5","key":"2026081810392179500_cit35","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nrmicro2746","article-title":"How glycan\nmetabolism shapes the\nhuman gut microbiota","volume":"10","author":"Koropatkin","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"issue":"7533","key":"2026081810392179500_cit36","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/nature13995","article-title":"Human gut\nBacteroidetes can utilize yeast mannan through a selfish mechanism","volume":"517","author":"Cuskin","year":"2015","journal-title":"Nature"},{"issue":"3","key":"2026081810392179500_cit37","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1053\/j.gastro.2023.05.032","article-title":"Gut Microbiome Composition Is Associated\nWith Future Onset of Crohn\u2019s Disease in Healthy First-Degree\nRelatives","volume":"165","author":"Garay","year":"2023","journal-title":"Gastroenterology"},{"issue":"8","key":"2026081810392179500_cit38","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1136\/gutjnl-2022-328048","article-title":"Faecal\nmetabolome\nand its determinants in inflammatory bowel disease","volume":"72","author":"Vila","year":"2023","journal-title":"Gut"},{"issue":"1","key":"2026081810392179500_cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26209-8","article-title":"High-coverage metabolomics uncovers microbiota-driven biochemical\nlandscape of interorgan transport and gut-brain communication in mice","volume":"12","author":"Lai","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"2026081810392179500_cit40","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2271620","article-title":"GlcNac produced by the gut microbiome enhances host influenza resistance\nby modulating NK cells","volume":"15","author":"Hu","year":"2023","journal-title":"Gut Microbes"},{"issue":"3","key":"2026081810392179500_cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0014108","article-title":"Gut microbiota-associated\nmetabolite N-acetyl-D-glucosamine alleviates systemic inflammatory\nresponses induced by acute Toxoplasma gondii infection","volume":"20","author":"Aykur","year":"2026","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"2026081810392179500_cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58660-2","article-title":"A Bacteroides\nthetaiotaomicron genetic\nlocus encodes activities consistent with mucin O-glycoprotein processing\nand N-acetylgalactosamine metabolism","volume":"16","author":"Ndeh","year":"2025","journal-title":"Nat. Commun."},{"issue":"12","key":"2026081810392179500_cit43","doi-asserted-by":"publisher","first-page":"4984","DOI":"10.1021\/acs.est.2c09390","article-title":"Food Thermal Labels\nare a Source of Dietary Exposure to Bisphenol\nS and Other Color Developers","volume":"57","author":"Xu","year":"2023","journal-title":"Environ. Sci.\nTechnol."},{"issue":"1","key":"2026081810392179500_cit44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3967\/bes2024.003","article-title":"Effects of Bisphenol\nA and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice","volume":"37","author":"Meng","year":"2024","journal-title":"Biomed. Environ. Sci."},{"key":"2026081810392179500_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2021.122792","article-title":"A dual-mode\nreactive matrix for sensitive and quantitative analysis of carbohydrates\nby MALDI-TOF MS","volume":"235","author":"Lin","year":"2021","journal-title":"Talanta"},{"issue":"8","key":"2026081810392179500_cit46","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1007\/s00216-024-05188-x","article-title":"Tissue distribution of metabolites\nin Cordyceps cicadae determined by DESI-MSI analysis","volume":"416","author":"Cao","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"2026081810392179500_cit47","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-025-06958-0","article-title":"Integrated morphological\nobservation, metabolomics,\nand transcriptomics to investigate the effect of growth years on the\nquality of Atractylodes macrocephala Koidz","volume":"25","author":"Cui","year":"2025","journal-title":"BMC Plant Biol."},{"key":"2026081810392179500_cit48","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.897528","article-title":"Desorption\nElectrospray Ionization Mass Spectrometry Imaging Illustrates\nthe Quality Characters of Isatidis Radix","volume":"13","author":"Nie","year":"2022","journal-title":"Front.\nPlant Sci."},{"issue":"50","key":"2026081810392179500_cit49","doi-asserted-by":"publisher","first-page":"20372","DOI":"10.1021\/acs.jafc.3c04996","article-title":"Spatial Distribution and Characterization\nof the Small-Molecule Metabolites\nand In Situ Hydrolyzed Oligosaccharides in the Rhizome of Glycyrrhiza\nuralensis by Desorption Electrospray Ionization-Mass Spectrometry\nImaging and High-Resolution Liquid Chromatography\u2013Mass Spectrometry","volume":"71","author":"Zhao","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"2026081810392179500_cit50","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202515742","article-title":"SR-B1-Mediated\nTransplacental Transfer\nof Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis","volume":"13","author":"Huang","year":"2026","journal-title":"Adv. Sci."},{"issue":"10","key":"2026081810392179500_cit51","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.tins.2013.07.001","article-title":"Sugar for the brain:\nthe role of glucose in physiological and pathological brain function","volume":"36","author":"Mergenthaler","year":"2013","journal-title":"Trends Neurosci."},{"issue":"3","key":"2026081810392179500_cit52","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.122","article-title":"Regulation\nof glucose metabolism from a liver-centric perspective","volume":"48","author":"Han","year":"2016","journal-title":"Exp. Mol. Med."},{"issue":"9","key":"2026081810392179500_cit53","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1007\/s00204-025-04106-z","article-title":"Environmental occurrence,\nhuman exposure routes, toxicity, and risk assessments of medium-chain\nchlorinated paraffins (MCCPs): a comprehensive review","volume":"99","author":"Yu","year":"2025","journal-title":"Arch. Toxicol."},{"issue":"51","key":"2026081810392179500_cit54","doi-asserted-by":"publisher","first-page":"17413","DOI":"10.1074\/jbc.RA120.015595","article-title":"N-acetylglucosamine\ndrives myelination by triggering oligodendrocyte precursor cell differentiation","volume":"295","author":"Sy","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"8","key":"2026081810392179500_cit55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202826s","article-title":"Distinct\nsubstrate specificity and physicochemical\ncharacterization of native human hepatic thymidine phosphorylase","volume":"13","author":"Trackman","year":"2018","journal-title":"PLoS One"},{"issue":"18","key":"2026081810392179500_cit56","doi-asserted-by":"publisher","first-page":"8972","DOI":"10.1021\/acs.est.4c09460","article-title":"Uncovering\nMitochondrial Defects Induced by Chemicals: A Case Study of Low-Dose\nMedium-Chain Chlorinated Paraffin Exposure","volume":"59","author":"Geng","year":"2025","journal-title":"Environ. Sci. Technol."}],"container-title":["Environmental Science &amp;\nTechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.6c07130","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/esthag\/article-pdf\/60\/32\/22287\/66355925\/acs.est.6c07130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/esthag\/article-pdf\/60\/32\/22287\/66355925\/acs.est.6c07130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:47:49Z","timestamp":1787071669000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/esthag\/article\/60\/32\/22287\/5238426\/Phosphonium-Chloride-Enhanced-Ionization-for-High"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":56,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,8,3]]},"published-print":{"date-parts":[[2026,8,18]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.est.6c07130","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]}}}