{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:22Z","timestamp":1792784662011,"version":"4.5.0"},"reference-count":84,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Guangxi Young Elite Scientist Sponsorship Program","award":["GXYESS2025047"],"award-info":[{"award-number":["GXYESS2025047"]}]},{"name":"National Natural Science Foundation of China","award":["82404313"],"award-info":[{"award-number":["82404313"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Natural ScienceFoundation of Guangxi Zhuang Autonomous Region","award":["2025GXNSFBA069336"],"award-info":[{"award-number":["2025GXNSFBA069336"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Arterial stiffness measured by estimated pulse wave velocity (ePWV) is an established predictor of cardiovascular disease. Long-term metal exposure may drive arterial stiffness progression, but prior studies largely relied on single-time assessments of exposure or outcome, overlooking heterogeneity in ePWV progression and its longitudinal links to long-term metal exposure. In an 11-year prospective study of 707 participants from the Manganese-Exposed Workers Healthy Cohort, we repeatedly quantified blood cell metals and computed cumulative exposure indices (CEIs). Latent class mixed models identified low and high ePWV trajectories. A one-quantile increase in CEI of a five-metal mixture [strontium (Sr), calcium (Ca), lead (Pb), magnesium, and manganese] was associated with belonging to the high ePWV trajectory (OR = 1.62; 95% CI: 1.14\u20132.31), with CEI_Sr and CEI_Pb as positive drivers and CEI_Ca inversely associated. The stronger CEI_Sr and CEI_Pb effects were observed in participants with high body mass index or smokers. The distinct trajectories of metal exposure were further identified; we found that the high-decreasing Pb trajectory was associated with higher odds of the high ePWV trajectory compared with the low-decreasing Pb trajectory (OR = 3.98; 95% CI: 1.28\u201313.26). We provided insights into the longitudinal links between long-term metal exposure and arterial stiffness progression, emphasizing the critical role of metal biomonitoring and primary prevention of arteriosclerosis in high-risk populations.<\/jats:p>","DOI":"10.1021\/acs.est.6c07147","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:02:03Z","timestamp":1790722923000},"page":"28385-28396","source":"Crossref","is-referenced-by-count":0,"title":["Strontium and Lead\nAccelerate, Calcium Protects: Arterial\nStiffness Progression in an 11-Year Prospective Cohort Study"],"prefix":"10.1021","volume":"60","author":[{"given":"Sencai","family":"Lin","sequence":"first","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiu","family":"He","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Bao","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Health Science College , , ,","place":["Nanning, China, 530023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifan","family":"Kong","sequence":"additional","affiliation":[{"name":"Guilin Medical University , , ,","place":["Guilin, China, 541000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuming","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Ge","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi University of Science and Technology , , , ,","place":["Liuzhou, Guangxi, China, 545006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-7724","authenticated-orcid":true,"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Health Science College , , ,","place":["Nanning, China, 530023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026101310164048600_cit1","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1093\/eurjpc\/zwae281","article-title":"Global burden of cardiovascular diseases: projections\nfrom 2025 to 2050","volume":"32","author":"Chong","year":"2025","journal-title":"Eur. 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