{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:42:44Z","timestamp":1792784564682,"version":"4.5.0"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"the Major Program of National Natural Science Foundation of China","award":["52293440, 52293442"],"award-info":[{"award-number":["52293440, 52293442"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The growing number and diversity of chemical contaminants threaten aquatic ecosystem integrity, yet conventional risk assessments often overlook food-web interactions and require extensive toxicological and ecological data. We developed the Generalized Ecotox-Criticality Framework (GECF), which reframes ecosystem risk assessment as a targeted dimensionality-reduction problem. GECF integrates food-web energy flux, ecological redundancy, and chemical-specific toxicity sensitivity to prioritize pollutant-specific nodal taxa for direct toxicity-data generation while retaining the complete ecosystem network. In the Baiyangdian case study, a cutoff sensitivity analysis supported the 80% relative criticality index (RCI) setting as a practical balance between response fidelity and testing burden. At this setting, nodal scenarios retained the principal ecosystem responses simulated by AQUATOX and yielded indicator-specific candidate ecological thresholds (ECO-thresholds) internally benchmarked against full-organism scenarios. Relative to the 14-taxon full-organism evidence set, the 80% RCI setting reduced the standardized weighted assay burden by 71.1%, the number of tested taxa by 69.1%, and the number of vertebrate test taxa by 66.7%. Additional analyses showed that nodal composition varied across chemicals and ecosystems and that candidate thresholds shifted under warming and nutrient-enrichment backgrounds. GECF provides a model-based decision-support approach for prioritizing toxicity-data generation and conducting scenario-dependent regional aquatic-ecosystem risk screening.<\/jats:p>","DOI":"10.1021\/acs.est.6c07420","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:13:27Z","timestamp":1788304407000},"page":"28408-28420","source":"Crossref","is-referenced-by-count":0,"title":["Toward a Generalized\nEcotox-Criticality Framework\nfor Targeted Aquatic Ecosystem Risk Assessment"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3517-950X","authenticated-orcid":true,"given":"Ren","family":"Ding","sequence":"first","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4431-6991","authenticated-orcid":true,"given":"Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-4989","authenticated-orcid":true,"given":"Dongbin","family":"Wei","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100085"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7799-5163","authenticated-orcid":true,"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhu","family":"Wu","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-849X","authenticated-orcid":true,"given":"Zitong","family":"Liao","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarong","family":"Qi","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-3959","authenticated-orcid":true,"given":"Hong-Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]},{"name":"Research Institute for Environmental Innovation (Suzhou), Tsinghua , ,","place":["Suzhou, China, 215163"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"issue":"6269","key":"2026101310173316700_cit1","doi-asserted-by":"publisher","first-page":"aad2622","DOI":"10.1126\/science.aad2622","article-title":"The Anthropocene\nIs Functionally and Stratigraphically Distinct from the Holocene","volume":"351","author":"Waters","year":"2016","journal-title":"Science"},{"issue":"1","key":"2026101310173316700_cit2","doi-asserted-by":"publisher","first-page":"7775","DOI":"10.1038\/s41467-025-63217-4","article-title":"Time to Strengthen\nthe Governance of New Contaminants in the Environment","volume":"16","author":"Zhao","year":"2025","journal-title":"Nat. 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