{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:55Z","timestamp":1792784695081,"version":"4.5.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P36287"],"award-info":[{"award-number":["P36287"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["Z437"],"award-info":[{"award-number":["Z437"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Commission (Horizon Europe Framework Programme)","award":["101079299"],"award-info":[{"award-number":["101079299"]}],"id":[{"id":"https:\/\/ror.org\/00k4n6c32","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microbial ammonia oxidation, the first and rate-limiting step of nitrification, plays a central role in soil nitrogen cycling. It is most relevant in agricultural soils as nitrifiers compete with crops for ammonia-based fertilizers. Therefore, synthetic nitrification inhibitors are widely used alongside fertilizers to reduce the activities of dominant drivers of this process, i.e., ammonia-oxidizing archaea (AOA) and bacteria (AOB). However, the physiological responses of ammonia oxidizers remain poorly resolved. Here, the response of the AOA Nitrososphaera viennensis to the nitrification inhibitors 3,4-dimethylpyrazole phosphate (DMPP) and allylthiourea (ATU) was investigated using a combination of functional genomics, physiological assays, and relief experiments. The results overturn earlier assumptions that DMPP and ATU act by chelating free copper. Both compounds affected ammonia oxidation and triggered broader shifts in energy metabolism and stress-response pathways, which diverged markedly between the two inhibitors. We propose a competitive inhibition of the ammonia monooxygenase complex with DMPP as it can be alleviated by additional ammonia and elicits activation of urea acquisition, while ATU acted as a noncompetitive inhibitor generally inducing quiescence. Both modes of inhibition were associated with clear transcriptomic and proteomic signals that will be advantageous for the identification of mechanisms of other nitrification inhibitors in the future.<\/jats:p>","DOI":"10.1021\/acs.est.6c08773","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:02:10Z","timestamp":1790755330000},"page":"28765-28780","source":"Crossref","is-referenced-by-count":0,"title":["Common Nitrification\nInhibitors Exhibit Distinct Mechanisms\non the Ammonia-Oxidizing Archaeon\n                    <i>Nitrososphaera viennensis<\/i>"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1969-0537","authenticated-orcid":true,"given":"Dimitrios","family":"Dalkidis","sequence":"first","affiliation":[{"name":"University of Thessaly , , ,","place":["Larissa, Greece, GR-41500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Malits","sequence":"additional","affiliation":[{"name":"University of Vienna , , Djerassiplatz 1 , ,","place":["Vienna, Austria, A-1030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Kerou","sequence":"additional","affiliation":[{"name":"University of Vienna , , Djerassiplatz 1 , ,","place":["Vienna, Austria, A-1030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadis","family":"Sajedi","sequence":"additional","affiliation":[{"name":"University of Vienna , , Djerassiplatz 1 , ,","place":["Vienna, Austria, A-1030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Afjehi-Sadat","sequence":"additional","affiliation":[{"name":"University of Vienna , , University Biology Building Djerassiplatz 1 , ,","place":["Vienna, Austria, A-1030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Schleper","sequence":"additional","affiliation":[{"name":"University of Vienna , , Djerassiplatz 1 , ,","place":["Vienna, Austria, A-1030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios G","family":"Karpouzas","sequence":"additional","affiliation":[{"name":"University of Thessaly , , ,","place":["Larissa, Greece, GR-41500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia S","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"University of Thessaly , , ,","place":["Larissa, Greece, GR-41500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8796-3840","authenticated-orcid":true,"given":"Logan H.","family":"Hodgskiss","sequence":"additional","affiliation":[{"name":"University of Vienna , , Djerassiplatz 1 , ,","place":["Vienna, Austria, A-1030"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"5878","key":"2026101310165581500_cit1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.1136674","article-title":"Transformation of the Nitrogen Cycle: Recent Trends,\nQuestions, and Potential Solutions","volume":"320","author":"Galloway","year":"2008","journal-title":"Science"},{"issue":"3","key":"2026101310165581500_cit2","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1890\/1051-0761(1997)007%5B0737:HAOTGN%5D2.0.CO;2","article-title":"Human Alteration\nof the Global Nitrogen Cycle: Sources and Consequences","volume":"7","author":"Vitousek","year":"1997","journal-title":"Ecol. Appl."},{"key":"2026101310165581500_cit3","doi-asserted-by":"publisher","DOI":"10.1787\/9789264307438-en","volume-title":"Human Acceleration of the\nNitrogen Cycle: managing Risks\nand Uncertainty","author":"OECD.","year":"2018"},{"issue":"4","key":"2026101310165581500_cit4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1080\/07352680600794232","article-title":"Scope and\nStrategies for Regulation of Nitrification in Agricultural Systems\u2500Challenges\nand Opportunities","volume":"25","author":"Subbarao","year":"2006","journal-title":"Critical Rev. Plant Sci."},{"issue":"6","key":"2026101310165581500_cit5","doi-asserted-by":"publisher","first-page":"17074","DOI":"10.1038\/nplants.2017.74","article-title":"Nitrogen\nTransformations in Modern Agriculture and the Role of Biological Nitrification\nInhibition","volume":"3","author":"Coskun","year":"2017","journal-title":"Nat. Plants"},{"key":"2026101310165581500_cit6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fmicb.2019.01931","article-title":"Controls and Adaptive\nManagement of Nitrification in\nAgricultural Soils","volume":"10","author":"Norton","year":"2019","journal-title":"Front. Microbiol"},{"issue":"1\u20133","key":"2026101310165581500_cit7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s10533-012-9802-4","article-title":"Nitrogen-Climate Interactions in\nUS Agriculture","volume":"114","author":"Robertson","year":"2013","journal-title":"Biogeochemistry"},{"issue":"1part2","key":"2026101310165581500_cit8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.4319\/lo.2006.51.1_part_2.0364","article-title":"Nitrogen as the Limiting Nutrient for Eutrophication\nin Coastal Marine Ecosystems: Evolving Views over Three Decades","volume":"51","author":"Howarth","year":"2006","journal-title":"Limnol. Oceanogr."},{"issue":"9","key":"2026101310165581500_cit9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/ngeo608","article-title":"The Contribution\nof Manure and Fertilizer Nitrogen to Atmospheric Nitrous Oxide since\n1860","volume":"2","author":"Davidson","year":"2009","journal-title":"Nat. Geosci."},{"key":"2026101310165581500_cit10","doi-asserted-by":"publisher","first-page":"8934","DOI":"10.1039\/D6SC01048B","article-title":"Ammonia\nMonooxygenase: A Work in\nProgress","volume":"17","author":"Arndt","year":"2026","journal-title":"Chem. Sci."},{"key":"2026101310165581500_cit11","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.joule.2018.01.018","article-title":"Alternative Bioenergy:\nUpdates to and Challenges in Nitrification Metalloenzymology","volume":"2","author":"Lancaster","year":"2018","journal-title":"Joule"},{"issue":"2","key":"2026101310165581500_cit12","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1128\/jb.176.2.504-510.1994","article-title":"Characterization\nof the Gene Encoding\nHydroxylamine Oxidoreductase in Nitrosomonas Europaea","volume":"176","author":"Sayavedra-Soto","year":"1994","journal-title":"J. Bacteriol"},{"issue":"2","key":"2026101310165581500_cit13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/0014-5793(83)80292-0","article-title":"O2 and\nH2O Are Each the Source\nof One O in NO\u20132 Produced from NH3 by Nitrosomonas: 15N-NMR Evidence","volume":"164","author":"Andersson","year":"1983","journal-title":"FEBS Lett."},{"issue":"7583","key":"2026101310165581500_cit14","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature16461","article-title":"Complete Nitrification by Nitrospira Bacteria","volume":"528","author":"Daims","year":"2015","journal-title":"Nature"},{"key":"2026101310165581500_cit15","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/nature16459","article-title":"Complete Nitrification\nby a Single Microorganism","volume":"528","author":"Kessel","year":"2015","journal-title":"Nature"},{"issue":"49","key":"2026101310165581500_cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601212113","article-title":"Proteomics and Comparative\nGenomics of Nitrososphaera Viennensis Reveal the\nCore Genome and Adaptations of Archaeal Ammonia Oxidizers","volume":"113","author":"Kerou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"19","key":"2026101310165581500_cit17","doi-asserted-by":"publisher","first-page":"8818","DOI":"10.1073\/pnas.0913533107","article-title":"Nitrosopumilus Maritimus Genome Reveals Unique Mechanisms for Nitrification and Autotrophy\nin Globally Distributed Marine Crenarchaea","volume":"107","author":"Walker","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7104","key":"2026101310165581500_cit18","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/nature04983","article-title":"Archaea Predominate\namong Ammonia-Oxidizing Prokaryotes in Soils","volume":"442","author":"Leininger","year":"2006","journal-title":"Nature"},{"issue":"5","key":"2026101310165581500_cit19","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/ismej.2010.171","article-title":"Examining the Global Distribution of Dominant Archaeal\nPopulations in Soil","volume":"5","author":"Bates","year":"2011","journal-title":"Isme J."},{"issue":"11","key":"2026101310165581500_cit20","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1111\/j.1462-2920.2008.01701.x","article-title":"The Influence of\nSoil pH on the Diversity, Abundance and Transcriptional Activity of\nAmmonia Oxidizing Archaea and Bacteria","volume":"10","author":"Nicol","year":"2008","journal-title":"Environ.\nMicrobiol"},{"issue":"9","key":"2026101310165581500_cit21","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/ngeo613","article-title":"Nitrification\nDriven\nby Bacteria and Not Archaea in Nitrogen-Rich Grassland Soils","volume":"2","author":"Di","year":"2009","journal-title":"Nat. Geosci."},{"key":"2026101310165581500_cit22","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.soilbio.2016.01.012","article-title":"Ammonia-Oxidizing\nBacteria Are More Responsive than Archaea to Nitrogen Source in an\nAgricultural Soil","volume":"96","author":"Ouyang","year":"2016","journal-title":"Soil Biol. Biochem."},{"key":"2026101310165581500_cit23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.soilbio.2017.06.010","article-title":"Ammonium\nAvailability and Temperature\nControl Contributions of Ammonia Oxidizing Bacteria and Archaea to\nNitrification in an Agricultural Soil","volume":"113","author":"Ouyang","year":"2017","journal-title":"Soil\nBiol. Biochem."},{"issue":"PART 8","key":"2026101310165581500_cit24","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1099\/ijs.0.063172-0","article-title":"Nitrososphaera Viennensis Gen. Nov., Sp. Nov., an Aerobic and Mesophilic,\nAmmonia-Oxidizing Archaeon from Soil and a Member of the Archaeal\nPhylum Thaumarchaeota","volume":"64","author":"Stieglmeier","year":"2014","journal-title":"Int.\nJ. Syst. Evol. Microbiol"},{"issue":"20","key":"2026101310165581500_cit25","doi-asserted-by":"publisher","first-page":"8420","DOI":"10.1073\/pnas.1013488108","article-title":"Nitrososphaera Viennensis, an Ammonia Oxidizing Archaeon from Soil","volume":"108","author":"Tourna","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"2026101310165581500_cit26","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/s41564-021-00918-8","article-title":"A Standardized\nArchaeal Taxonomy for the Genome Taxonomy Database","volume":"6","author":"Rinke","year":"2021","journal-title":"Nat. Microbiol."},{"issue":"1","key":"2026101310165581500_cit27","doi-asserted-by":"publisher","first-page":"wraf182","DOI":"10.1093\/ismejo\/wraf182","article-title":"Biofilm Lifestyle\nacross Different Lineages of Ammonia-Oxidizing\nArchaea","volume":"19","author":"Dreer","year":"2025","journal-title":"Isme J."},{"issue":"11","key":"2026101310165581500_cit28","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1038\/s41396-020-0715-2","article-title":"Genome Wide\nTranscriptomic Analysis of the Soil Ammonia Oxidizing Archaeon Nitrososphaera Viennensis upon Exposure to Copper Limitation","volume":"14","author":"Reyes","year":"2020","journal-title":"Isme J."},{"issue":"4","key":"2026101310165581500_cit29","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/s41396-023-01367-3","article-title":"Unexpected\nComplexity of the Ammonia Monooxygenase in Archaea","volume":"17","author":"Hodgskiss","year":"2023","journal-title":"Isme J."},{"issue":"10","key":"2026101310165581500_cit30","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00732-25","article-title":"Metabolic Response\nof a Chemolithoautotrophic Archaeon to Carbon Limitation","volume":"10","author":"Hodgskiss","year":"2025","journal-title":"mSystems"},{"key":"2026101310165581500_cit31","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fmicb.2023.1076342","article-title":"Analysis\nof Biomass Productivity and Physiology of Nitrososphaera Viennensis Grown in Continuous Culture","volume":"14","author":"Melcher","year":"2023","journal-title":"Front. Microbiol"},{"issue":"3\u20134","key":"2026101310165581500_cit32","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.resmic.2020.01.003","article-title":"Copper Limiting Threshold in the\nTerrestrial Ammonia Oxidizing Archaeon Nitrososphaera Viennensis","volume":"171","author":"Reyes","year":"2020","journal-title":"Res. Microbiol"},{"issue":"2","key":"2026101310165581500_cit33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/1574-6968.12164","article-title":"Responses\nof the Terrestrial Ammonia-Oxidizing Archaeon Ca.\nNitrososphaera Viennensis and the Ammonia-Oxidizing Bacterium Nitrosospira Multiformis to Nitrification Inhibitors","volume":"344","author":"Shen","year":"2013","journal-title":"FEMS Microbiol. Lett."},{"issue":"2","key":"2026101310165581500_cit34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s003740100380","article-title":"3,4-Dimethylpyrazole Phosphate (DMPP) \u2013 a New\nNitrification Inhibitor for Agriculture and Horticulture","volume":"34","author":"Zerulla","year":"2001","journal-title":"Biol. Fertil. Soils"},{"key":"2026101310165581500_cit35","doi-asserted-by":"publisher","first-page":"141885","DOI":"10.1016\/j.scitotenv.2020.141885","article-title":"Mechanism of Action\nof Nitrification\nInhibitors Based on Dimethylpyrazole: A Matter of Chelation","volume":"752","author":"Corrochano-Monsalve","year":"2021","journal-title":"Sci. Total Environ"},{"issue":"1","key":"2026101310165581500_cit36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40538-022-00321-3","article-title":"Evidences towards Deciphering\nthe Mode of Action of Dimethylpyrazole-Based Nitrification Inhibitors\nin Soil and Pure Cultures of Nitrosomonas Europaea","volume":"9","author":"Bozal-Leorri","year":"2022","journal-title":"Chem. Biol. Technol. Agric"},{"issue":"2","key":"2026101310165581500_cit37","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1128\/jb.115.2.480-485.1973","article-title":"Specific Inhibitors\nof Ammonia Oxidation in Nitrosomonas","volume":"115","author":"Hooper","year":"1973","journal-title":"J. Bacteriol"},{"issue":"1","key":"2026101310165581500_cit38","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1128\/mr.53.1.68-84.1989","article-title":"Biochemistry, and\nSpecific Inhibitors of CH4, NH4+,\nand CO Oxidation by Methanotrophs and\nNitrifiers","volume":"53","author":"Be\u0301dard","year":"1989","journal-title":"Microbiol Rev."},{"issue":"1","key":"2026101310165581500_cit39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s003740050518","article-title":"Modes of\nAction of Nitrification Inhibitors","volume":"29","author":"McCarty","year":"1999","journal-title":"Biol. Fertil.\nSoils"},{"issue":"1","key":"2026101310165581500_cit40","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/BF02045882","article-title":"The Effect of 2-Chloro, 6-(Trichloromethyl) Pyridine\non the Chemoautotrophic Metabolism of Nitrifying Bacteria I. Ammonia\nand Hydroxylamine Oxidation by Nitrosomonas","volume":"31","author":"Campbell","year":"1965","journal-title":"Antonie van Leeuwenhoek"},{"issue":"3","key":"2026101310165581500_cit41","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1073\/pnas.1214272110","article-title":"Hydroxylamine as an Intermediate\nin Ammonia Oxidation by Globally Abundant Marine Archaea","volume":"110","author":"Vajrala","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026101310165581500_cit42","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fmicb.2020.581283","article-title":"Comparison of Novel and Established\nNitrification Inhibitors Relevant to Agriculture on Soil Ammonia-\nand Nitrite-Oxidizing Isolates","volume":"11","author":"Papadopoulou","year":"2020","journal-title":"Front. Microbiol"},{"issue":"1","key":"2026101310165581500_cit43","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3390\/life5010818","article-title":"Archaeal\nClusters of Orthologous\nGenes (arCOGs): An Update and Application for Analysis of Shared Features\nbetween Thermococcales, Methanococcales, and Methanobacteriales","volume":"5","author":"Makarova","year":"2015","journal-title":"Life"},{"issue":"3","key":"2026101310165581500_cit44","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/j.1365-2958.2011.07834.x","article-title":"Cdv-Based Cell Division and Cell\nCycle Organization in the Thaumarchaeon Nitrosopumilus Maritimus","volume":"82","author":"Pelve","year":"2011","journal-title":"Mol. Microbiol."},{"issue":"6","key":"2026101310165581500_cit45","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1111\/1462-2920.14107","article-title":"Patterns\nof Thaumarchaeal Gene Expression\nin Culture and Diverse Marine Environments","volume":"20","author":"Carini","year":"2018","journal-title":"Environ. Microbiol"},{"issue":"7197","key":"2026101310165581500_cit46","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nature07004","article-title":"Structural Basis for\nthe Regulated Protease and Chaperone\nFunction of DegP","volume":"453","author":"Krojer","year":"2008","journal-title":"Nature"},{"issue":"11","key":"2026101310165581500_cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005752","article-title":"L. mixOmics: An\nR Package for \u2018omics Feature Selection and Multiple Data Integration","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput. Biol."},{"issue":"2","key":"2026101310165581500_cit48","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/ismej.2017.186","article-title":"Stress Response of a Marine Ammonia-Oxidizing\nArchaeon Informs Physiological Status of Environmental Populations","volume":"12","author":"Qin","year":"2018","journal-title":"Isme J."},{"issue":"4","key":"2026101310165581500_cit49","doi-asserted-by":"publisher","first-page":"fiag026","DOI":"10.1093\/femsec\/fiag026","article-title":"Copper\nRequirements and Copper Toxicity as Niche-Defining Factors in the\nGrowth of Terrestrial Ammonia-Oxidizing Archaea and Bacteria","volume":"102","author":"Oudova-Rivera","year":"2026","journal-title":"FEMS Microbiol. Ecol"},{"key":"2026101310165581500_cit50","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/s41564-023-01593-7","article-title":"Ammonia-Oxidizing\nBacteria and Archaea Exhibit Differential Nitrogen Source Preferences","volume":"9","author":"Qin","year":"2024","journal-title":"Nat. Microbiol"},{"key":"2026101310165581500_cit51","doi-asserted-by":"publisher","first-page":"105955","DOI":"10.1016\/j.apsoil.2025.105955","article-title":"Ammonia-Oxidizing Microorganisms\nOverwhelm Denitrifiers in Determining the Efficacy of DMPP in Upland\nSoils","volume":"207","author":"Lei","year":"2025","journal-title":"Applied Soil Ecology"},{"key":"2026101310165581500_cit52","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/S0038-0717(02)00165-7","article-title":"The\nNitrification\nInhibitor DMPP Had No Effect on Denitrifying Enzyme Activity","volume":"34","author":"Mu\u0308ller","year":"2002","journal-title":"Soil Biol. Biochem."},{"issue":"1","key":"2026101310165581500_cit53","doi-asserted-by":"publisher","first-page":"13810","DOI":"10.1038\/s41598-017-14225-y","article-title":"Dimethyl Pyrazol-Based\nNitrification Inhibitors Effect on Nitrifying and Denitrifying Bacteria\nto Mitigate N2O Emission","volume":"7","author":"Torralbo","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"2026101310165581500_cit54","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00253-008-1814-6","article-title":"Use of\nAllylthiourea to Produce Soluble\nMethane Monooxygenase in the Presence of Copper","volume":"82","author":"Yu","year":"2009","journal-title":"Appl. Microbiol. 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