{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:30:58Z","timestamp":1793727058234,"version":"4.6.1"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"43","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Basic Research Project for Young Students (Doctoral Program) of the National Natural Science Foundation of China","award":["524B2144"],"award-info":[{"award-number":["524B2144"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China","award":["52470043"],"award-info":[{"award-number":["52470043"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Major Program of the National Natural Science Foundation of China","award":["52293442"],"award-info":[{"award-number":["52293442"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Operational water quality management relies on physicochemical monitoring and targeted chemical analysis, but routine surveillance covers only a prioritized subset of high-risk contaminants and does not capture biological activity from unmonitored chemicals, transformation products, or complex mixtures. Whole-organism bioassays provide complementary effect information, yet the conventional Daphnia magna (D. magna) acute immobilization end point requires 48 h. Here, we introduce D-HEART (Daphnia-based Heartbeat Evaluation and Analysis for Rapid Toxicity Screening), a microfluidic imaging and analysis framework that converts high-speed cardiac recordings into 116 descriptors spanning morphology, pumping, wall motion kinematics, and synchrony. Within the tested response space, D-HEART assigns cardiac-response classes using a six-contaminant reference library, while its Heartbeat Toxicity Index (HTI) estimates 48 h immobilization from the predicted class and phenotype. Transcriptomic profiles provided molecular context for differentiated 1 h cardiac states. Post-training Cd(II) tests across environmental water matrices tracked immobilization with greater uncertainty than in laboratory water, and two untreated industrial wastewaters showed dose-responsive HTI estimates for mixed exposures from unseen contaminant classes. By linking early physiological states to transcriptional responses and later apical toxicity, D-HEART provides a rapid, cross-time scale effect-screening layer for operational water-quality evaluation, reducing the detection window by approximately 98% relative to the conventional 48 h immobilization end point.<\/jats:p>","DOI":"10.1021\/acs.est.6c09772","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:01:51Z","timestamp":1790913711000},"page":"30469-30481","source":"Crossref","is-referenced-by-count":0,"title":["Multidimensional\nCardiac Phenotyping of\n                    <i>Daphnia magna<\/i>\n                    Enables One-Hour Effect-Based Screening\nof Aquatic Toxicity"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-849X","authenticated-orcid":true,"given":"Zitong","family":"Liao","sequence":"first","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7799-5163","authenticated-orcid":true,"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4431-6991","authenticated-orcid":true,"given":"Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-4989","authenticated-orcid":true,"given":"Dongbin","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , ,","place":["Beijing, China, 100085"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-8210","authenticated-orcid":true,"given":"Xian-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-8990","authenticated-orcid":true,"given":"Yinhu","family":"Wu","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Long","family":"Wang","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarong","family":"Qi","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3517-950X","authenticated-orcid":true,"given":"Ren","family":"Ding","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-3959","authenticated-orcid":true,"given":"Hong-Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Tsinghua University , , ,","place":["Beijing, China, 100084"]},{"name":"Research Institute for Environmental Innovation (Suzhou) , Tsinghua , ,","place":["Suzhou, China, 215163"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"12","key":"2026110309382982700_cit1","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.3390\/s20123432","article-title":"Real-Time\nWater Quality Monitoring with Chemical Sensors","volume":"20","author":"Yaroshenko","year":"2020","journal-title":"Sensors"},{"issue":"1","key":"2026110309382982700_cit2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12302-019-0192-2","article-title":"Effect-based methods\nare key. The European Collaborative Project SOLUTIONS recommends integrating\neffect-based methods for diagnosis and monitoring of water quality","volume":"31","author":"Brack","year":"2019","journal-title":"Environ. Sci. Eur."},{"issue":"15","key":"2026110309382982700_cit3","doi-asserted-by":"publisher","first-page":"6023","DOI":"10.1021\/acs.est.2c06365","article-title":"Application of Effect-Based Methods\nto Water Quality\nMonitoring: Answering Frequently Asked Questions by Water Quality\nManagers, Regulators, and Policy Makers","volume":"57","author":"Neale","year":"2023","journal-title":"Environ.\nSci. Technol."},{"issue":"6753","key":"2026110309382982700_cit4","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1126\/science.adn5356","article-title":"Limitations\nof chemical monitoring hinder aquatic risk evaluations on the macroscale","volume":"388","author":"Bub","year":"2025","journal-title":"Science"},{"key":"2026110309382982700_cit5","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.scitotenv.2014.12.057","article-title":"Future water quality monitoring Adapting tools\nto deal with mixtures of pollutants in water resource management","volume":"512\u2013513","author":"Altenburger","year":"2015","journal-title":"Sci. Total Environ."},{"key":"2026110309382982700_cit6","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.watres.2017.07.016","article-title":"Development\nof a bioanalytical test battery for water quality monitoring: Fingerprinting\nidentified micropollutants and their contribution to effects in surface\nwater","volume":"123","author":"Neale","year":"2017","journal-title":"Water Res."},{"key":"2026110309382982700_cit7","doi-asserted-by":"publisher","DOI":"10.1787\/9789264069947-","volume-title":"Test No. 202: Daphnia sp. Acute Immobilisation Test; OECD\nGuidelines for the Testing of Chemicals, Section 2","author":"OECD.","year":"2004"},{"issue":"20","key":"2026110309382982700_cit8","doi-asserted-by":"publisher","first-page":"14237","DOI":"10.1021\/acs.est.2c01799","article-title":"Daphnia as a Sentinel Species for\nEnvironmental Health\nProtection: A Perspective on Biomonitoring and Bioremediation of Chemical\nPollution","volume":"56","author":"Abdullahi","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"2026110309382982700_cit9","doi-asserted-by":"publisher","first-page":"143038","DOI":"10.1016\/j.scitotenv.2020.143038","article-title":"Daphnia magna\nmodel in the toxicity assessment of pharmaceuticals: A review","volume":"763","author":"Tkaczyk","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"4","key":"2026110309382982700_cit10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00244-005-0121-9","article-title":"Physiological\nand Reproductive Effects\nof Beta Adrenergic Receptor Antagonists in Daphnia magna","volume":"50","author":"Dzialowski","year":"2006","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"6017","key":"2026110309382982700_cit11","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1126\/science.1197761","article-title":"The\nEcoresponsive Genome of Daphnia pulex","volume":"331","author":"Colbourne","year":"2011","journal-title":"Science"},{"key":"2026110309382982700_cit12","doi-asserted-by":"publisher","first-page":"109721","DOI":"10.1016\/j.ecoenv.2019.109721","article-title":"Rapid screening\nfor ecotoxicity of plating and semiconductor wastewater employing\nthe heartbeat of Daphnia magna","volume":"186","author":"Park","year":"2019","journal-title":"Ecotoxicol.\nEnviron. Saf."},{"key":"2026110309382982700_cit13","doi-asserted-by":"publisher","first-page":"134400","DOI":"10.1016\/j.scitotenv.2019.134400","article-title":"Physiological\nendpoints in daphnid acute toxicity tests","volume":"700","author":"Bownik","year":"2020","journal-title":"Sci.\nTotal Environ."},{"key":"2026110309382982700_cit14","doi-asserted-by":"publisher","first-page":"161268","DOI":"10.1016\/j.scitotenv.2022.161268","article-title":"Heart rate\nand behavioral responses in three phylogenetically\ndistant aquatic model organisms exposed to environmental concentrations\nof carbaryl and fenitrothion","volume":"865","author":"Bedrossiantz","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"9","key":"2026110309382982700_cit15","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.3390\/ani10091587","article-title":"Cardiovascular\nPerformance Measurement\nin Water Fleas by Utilizing High-Speed Videography and ImageJ Software\nand Its Application for Pesticide Toxicity Assessment","volume":"10","author":"Santoso","year":"2020","journal-title":"Animals"},{"issue":"19","key":"2026110309382982700_cit16","doi-asserted-by":"publisher","first-page":"jeb244729","DOI":"10.1242\/jeb.244729","article-title":"HeartCV: a\ntool for transferrable, automated measurement of heart rate and heart\nrate variability in transparent animals","volume":"225","author":"Ibbini","year":"2022","journal-title":"J.\nExp. Biol."},{"issue":"13","key":"2026110309382982700_cit17","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.3390\/ani12131670","article-title":"Automated Cardiac\nChamber Size and Cardiac Physiology\nMeasurement in Water Fleas by U-Net and Mask RCNN Convolutional Networks","volume":"12","author":"Saputra","year":"2022","journal-title":"Animals"},{"key":"2026110309382982700_cit18","doi-asserted-by":"publisher","first-page":"106676","DOI":"10.1016\/j.aquatox.2023.106676","article-title":"Using DeepLabCut\nfor markerless cardiac physiology and toxicity estimation in water\nfleas (Daphnia magna)","volume":"263","author":"Saputra","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"2026110309382982700_cit19","doi-asserted-by":"publisher","first-page":"146405","DOI":"10.1016\/j.scitotenv.2021.146405","article-title":"Real-time heart rate monitoring system\nfor cardiotoxicity\nassessment of Daphnia magna using high-speed digital holographic microscopy","volume":"780","author":"Kwon","year":"2021","journal-title":"Sci. Total Environ."},{"key":"2026110309382982700_cit20","doi-asserted-by":"publisher","first-page":"141474","DOI":"10.1016\/j.jhazmat.2026.141474","article-title":"High-throughput\nheart rate monitoring in Daphnia magna for sublethal\necotoxicological assessment","volume":"505","author":"Kwon","year":"2026","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"2026110309382982700_cit21","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted\ncorrelation network\nanalysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"issue":"12","key":"2026110309382982700_cit22","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1002\/etc.5620171217","article-title":"Combined effects of dissolved organic\nmaterial and water hardness on toxicity of cadmium to Daphnia magna","volume":"17","author":"Penttinen","year":"1998","journal-title":"Environ. Toxicol. Chem."},{"issue":"5","key":"2026110309382982700_cit23","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1021\/es102453b","article-title":"Acute Toxicity of Cadmium in Daphnia magna under Different\nCalcium and pH Conditions: Importance of Influx Rate","volume":"45","author":"Tan","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"2026110309382982700_cit24","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.aquatox.2017.08.015","article-title":"Cadmium stress assessment based on the electrocardiogram\ncharacteristics of zebra fish (Danio rerio): QRS complex could play\nan important role","volume":"191","author":"Xing","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"2026110309382982700_cit25","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.chemosphere.2018.09.014","article-title":"Toxic responses of\nzebrafish (Danio\nrerio) to thallium and deltamethrin characterized in the electrocardiogram","volume":"212","author":"Song","year":"2018","journal-title":"Chemosphere"},{"issue":"3","key":"2026110309382982700_cit26","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1021\/es0615573","article-title":"Daphnia magna Ecotoxicogenomics\nProvides Mechanistic Insights into Metal Toxicity","volume":"41","author":"Poynton","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"2026110309382982700_cit27","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.cbpc.2018.03.010","article-title":"Response\nof antioxidant enzymes to Cd and Pb exposure in water flea Daphnia\nmagna: Differential metal- and age-specific patterns","volume":"209","author":"Kim","year":"2018","journal-title":"Comp. Biochem. Physiol., Part C:Toxicol. Pharmacol."},{"issue":"38","key":"2026110309382982700_cit28","doi-asserted-by":"publisher","first-page":"16738","DOI":"10.1021\/acs.est.4c05105","article-title":"Molecular Events\nin Response to Triclosan-Induced Oxidative\nStress in CRISPR\/Cas9-Mediated p53-Targeted Mutants in Daphnia magna","volume":"58","author":"Lee","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"2026110309382982700_cit29","doi-asserted-by":"publisher","first-page":"105927","DOI":"10.1016\/j.aquatox.2021.105927","article-title":"Toxicogenomic differentiation of\nfunctional responses to fipronil and imidacloprid in Daphnia magna","volume":"238","author":"Pfaff","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"2026110309382982700_cit30","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.ecoenv.2017.10.042","article-title":"Neonicotinoid\ninsecticides imidacloprid, guadipyr,\nand cycloxaprid induce acute oxidative stress in Daphnia magna","volume":"148","author":"Qi","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"2026110309382982700_cit31","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways:\nA conceptual framework\nto support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"issue":"5","key":"2026110309382982700_cit32","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s10646-022-02541-7","article-title":"Altered life history\ntraits and transcripts of molting- and reproduction-related genes\nby cadmium in Daphnia magna","volume":"31","author":"Wei","year":"2022","journal-title":"Ecotoxicology"},{"issue":"10","key":"2026110309382982700_cit33","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23447","article-title":"Detection\nof triclosan using 2-domain hemoglobin promoter of Daphnia magna","volume":"37","author":"Yu","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"2026110309382982700_cit34","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.scitotenv.2018.01.340","article-title":"Effect-based\ntrigger values for in vitro and in vivo bioassays performed on surface\nwater extracts supporting the environmental quality standards (EQS)\nof the European Water Framework Directive","volume":"628\u2013629","author":"Escher","year":"2018","journal-title":"Sci.\nTotal Environ."},{"issue":"8","key":"2026110309382982700_cit35","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00254-003-0835-9","article-title":"Characterization\nof anthropogenic and natural sources of acid rock drainage at the\nCinnamon Gulch abandoned mine land inventory site, Summit County,\nColorado","volume":"44","author":"Bird","year":"2003","journal-title":"Environ. Geol."},{"issue":"5","key":"2026110309382982700_cit36","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.jestch.2019.12.002","article-title":"Detection of Chromium in surface\nand groundwater and its bio-absorption using bio-wastes and vermiculite","volume":"23","author":"Mani Tripathi","year":"2020","journal-title":"Eng. Sci. Technol. Int. J."},{"issue":"sp8","key":"2026110309382982700_cit37","doi-asserted-by":"publisher","first-page":"A29","DOI":"10.1890\/06-1497.1","article-title":"Pathways of Acid Mine Drainage to\nClear Lake: Implications\nfor Mercury Cycling","volume":"18","author":"Shipp","year":"2008","journal-title":"Ecol. Appl."},{"issue":"11","key":"2026110309382982700_cit38","doi-asserted-by":"publisher","first-page":"6769","DOI":"10.3390\/ijerph19116769","article-title":"Occurrence and Fate\nof Triclosan and Triclocarban in\nSelected Wastewater Systems across Durban Metropolis, KwaZulu-Natal,\nSouth Africa","volume":"19","author":"Bakare","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"16","key":"2026110309382982700_cit39","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1016\/S0043-1354(03)00335-X","article-title":"Triclosan\nin a sewage treatment process balances and monitoring data","volume":"37","author":"Bester","year":"2003","journal-title":"Water Res."},{"key":"2026110309382982700_cit40","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.envint.2014.10.024","article-title":"Neonicotinoid contamination\nof global surface waters and associated risk to aquatic invertebrates:\nA review","volume":"74","author":"Morrissey","year":"2015","journal-title":"Environ. Int."},{"issue":"12","key":"2026110309382982700_cit41","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.3390\/w12123388","article-title":"Literature\nReview: Global Neonicotinoid Insecticide Occurrence in Aquatic Environments","volume":"12","author":"Borsuah","year":"2020","journal-title":"Water"},{"issue":"7","key":"2026110309382982700_cit42","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.chemosphere.2009.05.002","article-title":"Hazard identification\nof imidacloprid to aquatic environment","volume":"76","author":"Tis\u030cler","year":"2009","journal-title":"Chemosphere"},{"issue":"1","key":"2026110309382982700_cit43","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1021\/es000253s","article-title":"A Biotic Ligand Model Predicting\nAcute Copper Toxicity for Daphnia magna: The Effects of Calcium, Magnesium,\nSodium, Potassium, and pH","volume":"36","author":"de Schamphelaere","year":"2002","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"2026110309382982700_cit44","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.ecoenv.2007.05.010","article-title":"Mixture toxicity of three toxicants\nwith similar and\ndissimilar modes of action to Daphnia magna","volume":"69","author":"Syberg","year":"2008","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"2026110309382982700_cit45","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1002\/etc.198","article-title":"Toxicity of three binary mixtures\nto Daphnia magna:\nComparing chemical modes of action and deviations from conceptual\nmodels","volume":"29","author":"Loureiro","year":"2010","journal-title":"Environ. Toxicol. Chem."}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.6c09772","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/esthag\/article-pdf\/60\/43\/30469\/68731562\/acs.est.6c09772.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/esthag\/article-pdf\/60\/43\/30469\/68731562\/acs.est.6c09772.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:38:49Z","timestamp":1793723929000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/esthag\/article\/60\/43\/30469\/5443666\/Multidimensional-Cardiac-Phenotyping-of-Daphnia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":45,"journal-issue":{"issue":"43","published-online":{"date-parts":[[2026,10,1]]},"published-print":{"date-parts":[[2026,11,3]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.est.6c09772","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}