{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:24Z","timestamp":1792784664935,"version":"4.5.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QD281"],"award-info":[{"award-number":["ZR2024QD281"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental Research Projects of Science and Technology Innovation and Development Plan in Yantai City","award":["2023JCYJ098"],"award-info":[{"award-number":["2023JCYJ098"]}]},{"name":"National Basic Research Program of China (973 Program)","award":["2024YFF0808801"],"award-info":[{"award-number":["2024YFF0808801"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["42206144\/32270533"],"award-info":[{"award-number":["42206144\/32270533"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sensitive functional end points reveal early responses to neuroactive wastewater contaminants but are rarely translated into screening thresholds. Using caffeine as a sentinel, we evaluated a behavior-based framework for coastal waters. Systematic searches of Web of Science Core Collection, PubMed, and Embase through 24 August 2026 identified 66 eligible studies and 2181 effect sizes for meta-analysis. The near-zero grand pooled signed ln\u202fRR may reflect cancellation among end points with opposing response directions. Responses varied by life stage, exposure duration, concentration, and end point category. Standardized light\u2013dark assays across eight aquatic species revealed taxon- and context-dependent behavioral disruptions, including responses at low concentration and non-monotonic patterns. Species sensitivity distributions based on behavioral benchmark concentrations yielded a conservative hazardous concentration affecting 5% of species (HC5; 0.0585 \u03bcg L\u20131) and a screening-level behavior-based predicted no-effect concentration (PNEC; 0.0195 \u03bcg L\u20131). A separate systematic literature search, supplemented with NORMAN EMPODAT records, compiled 1421 quantifiable caffeine measurements in coastal and estuarine waters. Concentrations were right-skewed (median, 44.9 ng L\u20131; IQR, 14.60\u2013190.00 ng L\u20131), and 69.88% of measurements fell into the high-priority risk quotient category (RQ \u2265 1). These findings support behavior-based thresholds for prioritizing neuroactive wastewater pollution in coastal waters.<\/jats:p>","DOI":"10.1021\/acs.est.6c10032","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:01:35Z","timestamp":1791374495000},"page":"29342-29354","source":"Crossref","is-referenced-by-count":0,"title":["Behavior-Based\nThresholds Support Screening-Level\nPrioritization of Caffeine as a Neuroactive Wastewater Micropollutant\nin Coastal Waters"],"prefix":"10.1021","volume":"60","author":[{"given":"Zhen","family":"Lu","sequence":"first","affiliation":[{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , ,","place":["Yantai, People\u2019s Republic of China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yan","sequence":"additional","affiliation":[{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , ,","place":["Yantai, People\u2019s Republic of China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , ,","place":["Yantai, People\u2019s Republic of China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , ,","place":["Yantai, People\u2019s Republic of China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxi","family":"Li","sequence":"additional","affiliation":[{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , ,","place":["Yantai, People\u2019s Republic of China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4869-5393","authenticated-orcid":true,"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , ,","place":["Yantai, People\u2019s Republic of China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"1","key":"2026102007524506100_cit1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1039\/C9EM00463G","article-title":"Emerging investigator series: use of behavioural endpoints\nin the regulation of chemicals","volume":"22","author":"\u00c5gerstrand","year":"2020","journal-title":"Environ. 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Toxicol. Chem."},{"key":"2026102007524506100_cit38","doi-asserted-by":"publisher","DOI":"10.3390\/jox15030086","article-title":"Impact of caffeine on aquatic ecosystems:\nAssessing trophic-level biological responses","volume":"15","author":"Rodrigues","year":"2025","journal-title":"J. Xenobiot."},{"issue":"1","key":"2026102007524506100_cit39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11356-010-0367-2","article-title":"Behavioural\necotoxicology, an early warning signal to assess environmental quality","volume":"18","author":"Hellou","year":"2011","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"2","key":"2026102007524506100_cit40","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/cz\/zox010","article-title":"Integrative behavioral ecotoxicology: bringing together\nfields to establish new insight to behavioral ecology, toxicology,\nand conservation","volume":"63","author":"Peterson","year":"2017","journal-title":"Curr. 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The European Collaborative Project SOLUTIONS recommends integrating\neffect-based methods for diagnosis and monitoring of water quality","volume":"31","author":"Brack","year":"2019","journal-title":"Environ. Sci. Eur."},{"key":"2026102007524506100_cit50","doi-asserted-by":"publisher","DOI":"10.1186\/s12302-018-0161-1","article-title":"Towards a holistic\nand solution-oriented monitoring of chemical status of European water\nbodies: how to support the EU strategy for a non-toxic environment?","volume":"30","author":"Brack","year":"2018","journal-title":"Environ. Sci. Eur."},{"key":"2026102007524506100_cit51","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.watres.2015.05.049","article-title":"Effect-based\ntrigger values for in\nvitro bioassays: Reading across from existing water quality guideline\nvalues","volume":"81","author":"Escher","year":"2015","journal-title":"Water Res."},{"issue":"6","key":"2026102007524506100_cit52","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060578","article-title":"Zebrafish\nas a screening model to study the single and joint effects of antibiotics","volume":"14","author":"Jijie","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"4","key":"2026102007524506100_cit53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043428","article-title":"Zebrafish\nas a potential model for\nneurodegenerative diseases: a focus on toxic metals implications","volume":"24","author":"Paduraru","year":"2023","journal-title":"Int. J. Mol. 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