{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:02Z","timestamp":1792784642031,"version":"4.5.0"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"National Natural Science Foundation of China (NSFC)","award":["22236006"],"award-info":[{"award-number":["22236006"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["224B2608"],"award-info":[{"award-number":["224B2608"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22506147"],"award-info":[{"award-number":["22506147"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Halobenzoquinone disinfection byproducts (DBPs) are emerging drinking water contaminants with high toxic potency, among which 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ) is the most frequently detected. Despite the advances achieved in the toxicity of 2,6-DCBQ, its toxicological profile remains incompletely characterized. Herein, we integrated network toxicology with mouse and zebrafish models to explore the toxicity of 2,6-DCBQ. Network toxicology analysis highlighted neurotoxicity as a high-priority predicted end point and identified neuroinflammation and monoaminergic disruption as candidate molecular events. After 28 days of oral exposure, 2,6-DCBQ accumulated in a dose-dependent manner in the mouse brain and induced reactive gliosis and inflammatory responses, particularly in the prefrontal cortex and the hypothalamus. Most dopamine and serotonin receptors exhibited varying degrees of suppression, whereas HTR3A was consistently upregulated across all examined brain regions. Molecular docking and molecular dynamics simulation provided preliminary evidence for the potential interaction between 2,6-DCBQ and HTR3A. In zebrafish larvae, environmentally relevant 2,6-DCBQ exposure also reduced dopaminergic neuron fluorescence and brain 5-HT levels and led to affective disorder-like behavior characterized by increased dark preference. These findings identify neuroinflammation and disrupted monoaminergic signaling as prominent features of 2,6-DCBQ-induced neurotoxicity and highlight the potential mental health risks of halobenzoquinone DBPs.<\/jats:p>","DOI":"10.1021\/acs.est.6c11071","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:02:00Z","timestamp":1790265720000},"page":"27649-27659","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Underexplored\nNeurotoxicity of 2,6-Dichloro-1,4-benzoquinone:\nInsights from Network Toxicology and\n                    <i>In Vivo<\/i>\n                    Models"],"prefix":"10.1021","volume":"60","author":[{"given":"Sheng","family":"Wei","sequence":"first","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]},{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Cao","sequence":"additional","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]},{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2019an","family":"Bao","sequence":"additional","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Chen","sequence":"additional","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-7322","authenticated-orcid":true,"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]},{"name":"Shanghai Institute of Pollution Control and Ecological Security , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Song","sequence":"additional","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-0034","authenticated-orcid":true,"given":"Daqiang","family":"Yin","sequence":"additional","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, China, 200092"]},{"name":"Shanghai Institute of Pollution Control and Ecological Security , ,","place":["Shanghai, China, 200092"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"issue":"1\u20133","key":"2026100609064684200_cit1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence,\nGenotoxicity, and Carcinogenicity of Regulated and Emerging Disinfection\nby-Products in Drinking Water: A Review and Roadmap for Research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. Res., Rev. Mutat. Res."},{"key":"2026100609064684200_cit2","unstructured":"U.S. Environmental Protection Agency.\n          . National Primary Drinking Water Regulations,\n40\nC.F.R. Part 141. https:\/\/www.ecfr.gov\/current\/title-40\/chapter-I\/subchapter-D\/part-141. (accessed September 9, 2026)."},{"key":"2026100609064684200_cit3","unstructured":"European Union.\n          . Directive\n(EU) 2020\/2184 of the European Parliament and of the Council of 16\nDecember 2020 on the Quality of Water Intended for Human Consumption. https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=OJ:L:2020:435:TOC (accessed September 9, 2026)."},{"key":"2026100609064684200_cit4","unstructured":"Ministry of Health of China.\n          . National Standard of the People\u2019s Republic of China, Standards\nfor Drinking Water Quality. https:\/\/favv-afsca.be\/sites\/default\/files\/export\/vtp\/cn\/03\/20240606_GB5749_2022.pdf (accessed September 9, 2026)."},{"issue":"42","key":"2026100609064684200_cit5","doi-asserted-by":"publisher","first-page":"22334","DOI":"10.1021\/acs.est.4c13900","article-title":"Disinfection Byproducts Confirmed over 50 Years: Systematic Curation,\nModes of Toxic Action, and Toxicogenomics","volume":"59","author":"Xiang","year":"2025","journal-title":"Environ.\nSci. Technol."},{"issue":"1\u20133","key":"2026100609064684200_cit6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tox.2011.05.004","article-title":"Potential Carcinogenic Hazards of Non-Regulated Disinfection\nby-Products: Haloquinones, Halo-Cyclopentene and Cyclohexene Derivatives,\nN-Halamines, Halonitriles, and Heterocyclic Amines","volume":"286","author":"Bull","year":"2011","journal-title":"Toxicology"},{"key":"2026100609064684200_cit7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jes.2017.05.024","article-title":"Elevated 8-Oxo-7,8-Dihydro-2\u2032-Deoxyguanosine\nin Genome of T24 Bladder Cancer Cells Induced by Halobenzoquinones","volume":"63","author":"Xu","year":"2018","journal-title":"J. Environ. Sci."},{"issue":"21","key":"2026100609064684200_cit8","doi-asserted-by":"publisher","first-page":"9125","DOI":"10.1021\/acs.est.4c03308","article-title":"Comprehensive Toxicological Assessment\nof Halobenzoquinones in Drinking\nWater at Environmentally Relevant Concentration","volume":"58","author":"Wang","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"14","key":"2026100609064684200_cit9","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1016\/j.watres.2012.05.032","article-title":"Occurrence\nand Formation of Chloro-\nand Bromo-Benzoquinones during Drinking Water Disinfection","volume":"46","author":"Zhao","year":"2012","journal-title":"Water Res."},{"issue":"3","key":"2026100609064684200_cit10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1021\/tx500494r","article-title":"Chemical\nand Toxicological Characterization of Halobenzoquinones, an Emerging\nClass of Disinfection Byproducts","volume":"28","author":"Li","year":"2015","journal-title":"Chem. Res.\nToxicol."},{"issue":"18","key":"2026100609064684200_cit11","doi-asserted-by":"publisher","first-page":"10590","DOI":"10.1021\/acs.est.8b02831","article-title":"Halobenzoquinone-Induced\nDevelopmental Toxicity, Oxidative Stress, and Apoptosis in Zebrafish\nEmbryos","volume":"52","author":"Wang","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"2026100609064684200_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117239","article-title":"The Key to 2,6-Dichloro-1,4-Benzoquinone\nReproductive Toxicity and Green Tea Detoxification: Covalent Binding\nand Competitive Binding","volume":"286","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ.\nSaf."},{"key":"2026100609064684200_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2023.153459","article-title":"Investigation of the Nephrotoxicity of 2,6-Dichloro-1,4-Benzoquinone\nDisinfection by-Product in Mice through a 28-Day Toxicity Test","volume":"487","author":"Liu","year":"2023","journal-title":"Toxicology"},{"key":"2026100609064684200_cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2026.154440","article-title":"Mitochondrial Toxicity\nof Emerging Disinfection Byproduct 2,6-Dichloro-1,4- Benzoquinone\nin Renal Proximal Tubule Cells: Oxidative Phosphorylation Impairment\nand Metabolic Reprogramming","volume":"523","author":"Chen","year":"2026","journal-title":"Toxicology"},{"issue":"10","key":"2026100609064684200_cit15","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1021\/acs.chemrestox.7b00156","article-title":"Multidrug\nResistance Protein 4 (MRP4\/ABCC4) Protects Cells from the Toxic Effects\nof Halobenzoquinones","volume":"30","author":"Li","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"2026100609064684200_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115357","article-title":"Oxidative Stress as\na Key Event in 2,6-Dichloro-1,4-Benzoquinone-Induced\nNeurodevelopmental Toxicity","volume":"263","author":"Liu","year":"2023","journal-title":"Ecotoxicol. Environ.\nSaf."},{"issue":"3","key":"2026100609064684200_cit17","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1021\/acs.est.5c14563","article-title":"The Dose\nMakes the Poison\u201d: Relevance of Paracelsus\u2019s Principle\nfor Modern Chemical Hazard Assessment with New Approach Methodologies","volume":"60","author":"Escher","year":"2026","journal-title":"Environ. Sci. Technol."},{"issue":"W1","key":"2026100609064684200_cit18","doi-asserted-by":"publisher","first-page":"W422","DOI":"10.1093\/nar\/gkae236","article-title":"ADMETlab 3.0:\nAn Updated Comprehensive Online ADMET Prediction Platform Enhanced\nwith Broader Coverage, Improved Performance, API Functionality and\nDecision Support","volume":"52","author":"Fu","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"2026100609064684200_cit19","doi-asserted-by":"publisher","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0:\nA Webserver for the Prediction of Toxicity of Chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"1 D","key":"2026100609064684200_cit20","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING\nDatabase in 2023: Protein-Protein Association Networks and Functional\nEnrichment Analyses for Any Sequenced Genome of Interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"21","key":"2026100609064684200_cit21","doi-asserted-by":"publisher","first-page":"10204","DOI":"10.1021\/acs.est.5c03906","article-title":"Combined Analysis\nof Network Toxicology and Multiomics Revealed the Potential Mechanism\nof 6PPDQ-Induced Hepatotoxicity in Mice","volume":"59","author":"Li","year":"2025","journal-title":"Environ.\nSci. Technol."},{"key":"2026100609064684200_cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2025.154207","article-title":"Integrated Transcriptomic and Metabolomic\nAnalysis Reveals the Induction of Anoikis in Renal Proximal Tubular\nEpithelial Cells by 2,6-Dichloro-1,4-Benzoquinone","volume":"517","author":"Xu","year":"2025","journal-title":"Toxicology"},{"key":"2026100609064684200_cit23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jes.2022.03.042","article-title":"Neurotoxicity and Transcriptome Changes\nin Embryonic Zebrafish Induced by Halobenzoquinone Exposure","volume":"117","author":"Yang","year":"2022","journal-title":"J. Environ. Sci."},{"issue":"1","key":"2026100609064684200_cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07233-5","article-title":"Hierarchy in the Home\nCage Affects Behaviour and Gene Expression in Group-Housed C57BL\/6\nMale Mice","volume":"7","author":"Horii","year":"2017","journal-title":"Sci. Rep."},{"issue":"39","key":"2026100609064684200_cit25","doi-asserted-by":"publisher","first-page":"17247","DOI":"10.1021\/acs.est.4c04342","article-title":"Brominated Flame Retardant HBCD and Artificial Light\nat Night Synergically\nCaused Visual Disorder and Sleep Difficulty in Zebrafish Larvae","volume":"58","author":"Cao","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"2026100609064684200_cit26","doi-asserted-by":"publisher","first-page":"4914","DOI":"10.1021\/acs.est.3c08506","article-title":"Mixed Metal\nComponents in PM 2.5\nContribute to Chemokine Receptor CCR5-Mediated Neuroinflammation and\nNeuropathological Changes in the Mouse Olfactory Bulb","volume":"58","author":"Wei","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"155","key":"2026100609064684200_cit27","doi-asserted-by":"publisher","DOI":"10.3791\/60575","article-title":"Whole Mount\nImmunohistochemistry in Zebrafish Embryos\nand Larvae","author":"Hammond-Weinberger","year":"2020","journal-title":"J. Vis. Exp."},{"issue":"26","key":"2026100609064684200_cit28","doi-asserted-by":"publisher","first-page":"9592","DOI":"10.1021\/acs.est.3c01716","article-title":"BDE-47 Causes Depression-like Effects\nin Zebrafish Larvae via a Non-Image-Forming Visual Mechanism","volume":"57","author":"Cao","year":"2023","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"2026100609064684200_cit29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: Biology\nand Pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"13","key":"2026100609064684200_cit30","doi-asserted-by":"publisher","first-page":"6744","DOI":"10.1021\/acs.est.5b05585","article-title":"Emerging Disinfection\nByproducts, Halobenzoquinones: Effects of Isomeric Structure and Halogen\nSubstitution on Cytotoxicity, Formation of Reactive Oxygen Species,\nand Genotoxicity","volume":"50","author":"Li","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"2026100609064684200_cit31","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative Stress,\nInflammation, and Cancer: How Are They Linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"2026100609064684200_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1453","article-title":"Effects of\nEarly Postnatal Exposure to Fine Particulate Matter on Emotional and\nCognitive Development and Structural Synaptic Plasticity in Immature\nand Mature Rats","volume":"9","author":"Liu","year":"2019","journal-title":"Brain Behav."},{"issue":"7","key":"2026100609064684200_cit33","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049177","article-title":"Bisphenol-A Impairs\nSynaptic Formation and Function by RGS4-Mediated Regulation of BDNF\nSignaling in the Cerebral Cortex","volume":"15","author":"Hyun","year":"2022","journal-title":"Dis. Model.\nMech."},{"key":"2026100609064684200_cit34","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.02.004.2008","article-title":"Excitation\nControl: Balancing PSD-95 Function at the\nSynapse","volume":"1","author":"Keith","year":"2008","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"2026100609064684200_cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45971-w","article-title":"PSD-95 Deficiency Disrupts\nPFC-Associated Function and Behavior during\nNeurodevelopment","volume":"9","author":"Coley","year":"2019","journal-title":"Sci. Rep."},{"key":"2026100609064684200_cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00199","article-title":"Serotonin-Prefrontal\nCortical Circuitry\nin Anxiety and Depression Phenotypes: Pivotal Role of Pre- and Post-Synaptic\n5-HT1A Receptor Expression","volume":"8","author":"Albert","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"9","key":"2026100609064684200_cit37","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA Axis in Major Depression:\nClassical Theories\nand New Developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"2026100609064684200_cit38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.pbb.2015.05.014","article-title":"Pharmacological\nStudy of the Light\/Dark Preference Test in Zebrafish (Danio Rerio):\nWaterborne Administration","volume":"135","author":"Magno","year":"2015","journal-title":"Pharmacol., Biochem.\nBehav."},{"issue":"8","key":"2026100609064684200_cit39","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.039446","article-title":"The Zebrafish Subcortical Social Brain as a Model for\nStudying Social Behavior Disorders","volume":"12","author":"Geng","year":"2019","journal-title":"Dis. Model.\nMech."},{"key":"2026100609064684200_cit40","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.lfs.2018.08.050","article-title":"Serotonin Receptors\nin Depression and Anxiety: Insights from Animal Studies","volume":"210","author":"z\u0307mudzka","year":"2018","journal-title":"Life Sci."},{"issue":"5","key":"2026100609064684200_cit41","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1017\/S1461145712001058","article-title":"The Rapid Recovery\nof 5-HT Cell Firing Induced by the\nAntidepressant Vortioxetine Involves 5-HT3 Receptor Antagonism","volume":"16","author":"Be\u0301try","year":"2013","journal-title":"Int. J. Neuropsychopharmacol.y"},{"issue":"12","key":"2026100609064684200_cit42","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1038\/aps.2014.89","article-title":"Antidepressant-like Effects of a\nNovel 5-HT3 Receptor Antagonist 6z in Acute and Chronic Murine Models\nof Depression","volume":"35","author":"Gupta","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"issue":"15","key":"2026100609064684200_cit43","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1111\/bph.13857","article-title":"Response of Htr3a Knockout Mice to\nAntidepressant Treatment and Chronic Stress","volume":"174","author":"Martin","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"16","key":"2026100609064684200_cit44","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1111\/bph.13197","article-title":"Agonist- and Antagonist-induced\nUp-regulation of Surface 5-HT3A Receptors","volume":"172","author":"Morton","year":"2015","journal-title":"Br.\nJ. Pharmacol."},{"issue":"5","key":"2026100609064684200_cit45","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1021\/envhealth.5c00286","article-title":"Disinfection Byproducts,\nOxidative Stress, and Sleep\nQuality among Healthy Chinese Men","volume":"4","author":"Xu","year":"2026","journal-title":"Environ.\nHealth"}],"container-title":["Environmental Science &amp;\nTechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.6c11071","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/esthag\/article-pdf\/60\/39\/27649\/68641043\/acs.est.6c11071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/esthag\/article-pdf\/60\/39\/27649\/68641043\/acs.est.6c11071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:30:27Z","timestamp":1791293427000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/esthag\/article\/60\/39\/27649\/5437798\/Unveiling-the-Underexplored-Neurotoxicity-of-2-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":45,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,24]]},"published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.est.6c11071","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}