{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:24Z","timestamp":1792784664920,"version":"4.5.0"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"National Natural Science Foundation of China (NSFC)","award":["22476026"],"award-info":[{"award-number":["22476026"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22576037"],"award-info":[{"award-number":["22576037"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>How the concurrent impairment of the skin and respiratory barriers is associated with distal-organ injury remains unclear. Here, we integrated untargeted and spatial metabolomics with in situ immunofluorescence to characterize lung-blood-heart-kidney changes in a mouse model of atopic dermatitis (AD) and cooking oil fume (COF) co-exposure. The AD+COF group showed the largest systemic increases in IL-6 and TNF-alpha and the most pronounced changes in circulating and organ metabolites. Succinate accumulation, depletion of xanthine and uric acid, glucose-related perturbations, and spatial lipid remodeling were observed across blood, lungs, heart, and kidneys, and several features were strongly correlated across compartments. These patterns are consistent with coordinated disturbance of tricarboxylic acid cycle-related, pentose phosphate, purine, and membrane-lipid metabolism. Because metabolite tracing, receptor blockade, ATP\/ADP measurements, and mitochondrial respiratory assays were not performed, the data do not establish metabolite transport or causal signaling between organs. Instead, they support an association-based cross-organ framework and identify candidate pathways for functional validation. Environmental extrapolation also requires caution because a controlled high-concentration COF regimen was used.<\/jats:p>","DOI":"10.1021\/acs.est.6c11745","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:01:23Z","timestamp":1790856083000},"page":"28553-28565","source":"Crossref","is-referenced-by-count":0,"title":["Metabolite-Associated\nInflammation during Combined\nExposure to Cooking Oil Fumes and Atopic Dermatitis: A Multi-Organ\nSpatial Metabolomics Study"],"prefix":"10.1021","volume":"60","author":[{"given":"Bailiang","family":"Liu","sequence":"first","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200438"]},{"name":"Institute of Eco-Chongming (IEC) , ,","place":["Shanghai, China, 202162"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200438"]},{"name":"Institute of Eco-Chongming (IEC) , ,","place":["Shanghai, China, 202162"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Li","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200438"]},{"name":"Institute of Eco-Chongming (IEC) , ,","place":["Shanghai, China, 202162"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-779X","authenticated-orcid":true,"given":"Jinzhuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-9683","authenticated-orcid":true,"given":"Lidia","family":"Morawska","sequence":"additional","affiliation":[{"name":"Queensland University of Technology , , , ,","place":["Brisbane, Queensland, Australia, 4001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-9173","authenticated-orcid":true,"given":"Lina","family":"Wang","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200438"]},{"name":"Institute of Eco-Chongming (IEC) , ,","place":["Shanghai, China, 202162"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026101310154622900_cit1","doi-asserted-by":"publisher","first-page":"117103","DOI":"10.1016\/j.envres.2023.117103","article-title":"A comprehensive\nreview on environmental pollutants and osteoporosis: Insights into\nmolecular pathways","volume":"237","author":"Snega Priya","year":"2023","journal-title":"Environ. Res."},{"issue":"2","key":"2026101310154622900_cit2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.jaci.2016.06.002","article-title":"Multifactorial\nskin barrier deficiency and atopic dermatitis:\nEssential topics to prevent the atopic march","volume":"138","author":"Egawa","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"35","key":"2026101310154622900_cit3","doi-asserted-by":"publisher","first-page":"15511","DOI":"10.1021\/acs.est.4c06035","article-title":"Unraveling Cross-Organ Impacts of Airborne Pollutants: A Multiomics\nStudy on Respiratory Exposure and Gastrointestinal Health","volume":"58","author":"Liu","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"2026101310154622900_cit4","doi-asserted-by":"publisher","first-page":"126680","DOI":"10.1016\/j.envpol.2025.126680","article-title":"Pollutant\ndistribution in vertebrates across scales:\nOrgans, cells, and organelles","volume":"382","author":"Ren","year":"2025","journal-title":"Environ. Pollut."},{"key":"2026101310154622900_cit5","doi-asserted-by":"publisher","first-page":"100454","DOI":"10.1016\/j.hazadv.2024.100454","article-title":"Dermatitis, a nightmare for those\nexposed to environmental pollutants","volume":"15","author":"Khoshakhlagh","year":"2024","journal-title":"J. Hazard.\nMater. Adv."},{"key":"2026101310154622900_cit6","doi-asserted-by":"publisher","first-page":"103355","DOI":"10.1016\/j.etap.2020.103355","article-title":"Relationship\nof chronic kidney disease with major air\npollutants - A systematic review and meta-analysis of observational\nstudies","volume":"76","author":"Liu","year":"2020","journal-title":"Environ. Toxicol. Pharmacol"},{"key":"2026101310154622900_cit7","doi-asserted-by":"publisher","first-page":"127399","DOI":"10.1016\/j.envpol.2025.127399","article-title":"Interplay between lung and intestine\nin responses to\ndiesel exhaust particles: Contrasting intestinal effects of cleared\nand swallowed particles with lung-mediated effects using an in vitro\napproach","volume":"389","author":"Gunasingam","year":"2026","journal-title":"Environ. Pollut."},{"key":"2026101310154622900_cit8","doi-asserted-by":"publisher","first-page":"114541","DOI":"10.1016\/j.addr.2022.114541","article-title":"Cytokine conjugates\nto elastin-like polypeptides","volume":"190","author":"Gong","year":"2022","journal-title":"Adv. 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Allergy Asthma Rep."},{"issue":"1","key":"2026101310154622900_cit16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/bjd.18781","article-title":"The impact of airborne pollution\non atopic dermatitis: a literature review","volume":"183","author":"Hendricks","year":"2020","journal-title":"Br.\nJ. Dermatol"},{"issue":"Supplement_1","key":"2026101310154622900_cit17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab849.144","article-title":"Circulating extracellular\nvesicles correlate with nocturnal blood pressure and vascular organ\ndamage and may serve as an integrative biomarker of vascular health","volume":"43","author":"Lugo Gavidia","year":"2022","journal-title":"Eur. Heart J"},{"issue":"11","key":"2026101310154622900_cit18","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1080\/14789450.2018.1531710","article-title":"Red blood\ncells as an organ? How deep omics characterization of the most abundant\ncell in the human body highlights other systemic metabolic functions\nbeyond oxygen transport","volume":"15","author":"Nemkov","year":"2018","journal-title":"Expert Rev. Proteomics"},{"key":"2026101310154622900_cit19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2021.01.036","article-title":"Energy substrate\nmetabolism and mitochondrial oxidative stress in cardiac ischemia\/reperfusion\ninjury","volume":"165","author":"Dambrova","year":"2021","journal-title":"Free Radical Biol. 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Immunol.: Pract"},{"issue":"7","key":"2026101310154622900_cit25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271985","article-title":"The causal\nrelationship between allergic\ndiseases and heart failure: Evidence from Mendelian randomization\nstudy","volume":"17","author":"Guo","year":"2022","journal-title":"PLoS One"},{"issue":"7","key":"2026101310154622900_cit26","doi-asserted-by":"publisher","first-page":"076001","DOI":"10.1289\/EHP11506","article-title":"Effect\nof Air Pollution on Heart Failure: Systematic Review and Meta-Analysis","volume":"131","author":"Jia","year":"2023","journal-title":"Environ. Health Perspect"},{"key":"2026101310154622900_cit27","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.aninu.2023.04.009","article-title":"Nutritional\nregulation of skeletal muscle energy metabolism,\nlipid accumulation and meat quality in pigs","volume":"14","author":"Yan","year":"2023","journal-title":"Anim. Nutr."},{"issue":"1","key":"2026101310154622900_cit28","doi-asserted-by":"publisher","first-page":"7322","DOI":"10.1038\/s41598-022-10907-4","article-title":"Modified lipid\nmetabolism and cytosolic phospholipase\nA2 activation in mesangial cells under pro-inflammatory conditions","volume":"12","author":"Boi","year":"2022","journal-title":"Sci. Rep."},{"issue":"3","key":"2026101310154622900_cit29","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00395-024-01042-4","article-title":"Insulin\nand glycolysis dependency of cardioprotection\nby nicotinamide riboside","volume":"119","author":"Xiao","year":"2024","journal-title":"Basic Res Cardiol"},{"issue":"8","key":"2026101310154622900_cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2526325123","article-title":"Nonoxidative pentose phosphate pathway regulates CD8+ T cell immunity\nby maintaining NADPH homeostasis","volume":"123","author":"Feng","year":"2026","journal-title":"Proc. Natl.\nAcad. Sci. U. S. A."},{"issue":"9","key":"2026101310154622900_cit31","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1002\/cbin.12204","article-title":"Mitochondria\nfission accentuates\noxidative stress in hyperglycemia-induced H9c2 cardiomyoblasts in\nvitro by regulating fatty acid oxidation","volume":"48","author":"Song","year":"2024","journal-title":"Cell\nBiology Int."},{"issue":"5","key":"2026101310154622900_cit32","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101908R","article-title":"Prostaglandin F2\u03b1\nevokes vasoconstrictor and vasodepressor activities that are both\nindependent of the F prostanoid receptor","volume":"36","author":"Zeng","year":"2022","journal-title":"Faseb\nJ."},{"key":"2026101310154622900_cit33","doi-asserted-by":"publisher","first-page":"110539","DOI":"10.1016\/j.exer.2025.110539","article-title":"Unveiling purine metabolism targets in the pathogenesis of fungal\nKeratitis: A combined proteomics and metabolomics approach","volume":"259","author":"Zhang","year":"2025","journal-title":"Exp. Eye Res."},{"issue":"1","key":"2026101310154622900_cit34","doi-asserted-by":"publisher","first-page":"2498105","DOI":"10.1080\/13510002.2025.2498105","article-title":"Is uric acid a true\nantioxidant? Identification of uric acid oxidation products and their\nbiological effects","volume":"30","author":"Pinz","year":"2025","journal-title":"Redox Rep."},{"issue":"1","key":"2026101310154622900_cit35","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1186\/s12951-026-04548-2","article-title":"Asymmetric nanozymes\nimprove cardiac purine catabolism and alleviate\noxidative stress of myocardium to treat ischemic heart disease","volume":"24","author":"Jiang","year":"2026","journal-title":"J. Nanobiotechnol"},{"issue":"1","key":"2026101310154622900_cit36","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.bbrc.2019.02.061","article-title":"Autocrine\npurinergic signaling stimulated by cell membrane disruption is involved\nin both cell membrane repair and adaptive response in MDCK cells","volume":"511","author":"Togo","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"2026101310154622900_cit37","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.pharep.2015.12.008","article-title":"Regulation of sphingomyelin\nmetabolism","volume":"68","author":"Bienias","year":"2016","journal-title":"Pharmacol.\nRep."},{"issue":"1","key":"2026101310154622900_cit38","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1161\/ATVBAHA.122.318443","article-title":"Alterations to\nSphingomyelin Metabolism Affect Hemostasis and Thrombosis","volume":"43","author":"Wang","year":"2023","journal-title":"Arterioscler., Thromb., Vasc. 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