{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:33:32Z","timestamp":1792114412351,"version":"4.4.0"},"reference-count":79,"publisher":"American Chemical Society (ACS)","issue":"14","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21737004"],"award-info":[{"award-number":["21737004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31320103915"],"award-info":[{"award-number":["31320103915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB14040202"],"award-info":[{"award-number":["XDB14040202"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2018,7,17]]},"DOI":"10.1021\/acs.est.8b01714","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T16:03:20Z","timestamp":1529597000000},"page":"8005-8015","source":"Crossref","is-referenced-by-count":177,"title":["Hepatotoxic Effects of Hexafluoropropylene Oxide Trimer Acid (HFPO-TA), A Novel Perfluorooctanoic Acid (PFOA) Alternative, on Mice"],"prefix":"10.1021","volume":"52","author":[{"given":"Nan","family":"Sheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitao","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-5597","authenticated-orcid":true,"given":"Jiayin","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1071\/EN11053"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/ieam.258"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2015.12.008"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2015.11.113"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm128"},{"key":"ref6\/cit6","unstructured":"U.S.\nEnvironmental Protection\nAgency. 2010\/2015 PFOA stewardship\nprogram. 2006."},{"key":"ref7\/cit7","unstructured":"Committee for Risk Assessment. Background document to the opinion\non the Annex XV dossier proposing restrictions on perfluorooctanoic\nacid (PFOA), PFOA salts and PFOA-related substances. 2015."},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/cen-v088n041.p012"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.11.013"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b01215"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.6b00398"},{"key":"ref12\/cit12","unstructured":"Dupont. Dupont\n                      TM\n                      Genx processing aid for making fluoropolymer resins. 2010."},{"key":"ref13\/cit13","unstructured":"LFU\n(Bavarian Enviroment Agency). PFOA und ADONA messungen an derprobenahmestelle\nalz. 2016, Online: https:\/\/www.lfu.bayern.de\/altlasten\/pfoa_gendorf\/adona\/index.htm."},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2016.12.014"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b05591"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b02259"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b03662"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2055-1"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2010.09.008"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2015.12.006"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.01.009"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.06.001"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3376"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570060202"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.03.022"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1917-2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b02102"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.10.017"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfw267"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b00778"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.04.016"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.24.300"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-014-1322-7"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(01)00466-0"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/68.1.249"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7643-8340-4_3"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.09.002"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-5-200803040-00005"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/626319"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/28.1.56"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104436"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.01.023"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104436"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000233380.13087.37"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901827"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2015.01.042"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307943"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056969"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/srep02174"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314551841"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(98)01349-8"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308318216"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308318208"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1080\/10408440490464705"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.856"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm110"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2000.020003191.x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/35013000"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn025"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071812-161220"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.07.010"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.06.013"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0072-5"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i3.323"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031565"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.121-a340"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1306615"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045119"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3390\/genes8040123"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1281-x"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv165"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2014.05.002"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16346"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20531-w"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.4137\/CMO.S10358"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-014-9518-0"},{"issue":"6","key":"ref77\/cit77","first-page":"7173","volume":"8","author":"Ding W. J.","year":"2015","journal-title":"Int. J. Clin. Exp. Patho."},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2015.06.031"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3300-y"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.8b01714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T10:06:05Z","timestamp":1681466765000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.8b01714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":79,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,7,17]]}},"alternative-id":["10.1021\/acs.est.8b01714"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.8b01714","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,21]]}}}