{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:16:16Z","timestamp":1791076576114,"version":"4.1.0"},"reference-count":114,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT097835MF"],"award-info":[{"award-number":["WT097835MF"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT101650MA"],"award-info":[{"award-number":["WT101650MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["620033640"],"award-info":[{"award-number":["620033640"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L01548X\/1"],"award-info":[{"award-number":["BB\/L01548X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"publisher","award":["610040829"],"award-info":[{"award-number":["610040829"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"publisher","award":["NE\/L007371\/1"],"award-info":[{"award-number":["NE\/L007371\/1"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The plastic monomer bisphenol A (BPA) is one of the highest production volume chemicals in the world and is frequently detected in wildlife and humans, particularly children. BPA has been associated with numerous adverse health outcomes relating to its estrogenic and other hormonal properties, but direct causal links are unclear in humans and animal models. Here we simulated measured (1\u00d7) and predicted worst-case (10\u00d7 ) maximum fetal exposures for BPA, or equivalent concentrations of its metabolite MBP, using fluorescent reporter embryo-larval zebrafish, capable of quantifying Estrogen Response Element (ERE) activation throughout the body. Heart valves were primary sites for ERE activation by BPA and MBP, and transcriptomic analysis of microdissected heart tissues showed that both chemicals targeted several molecular pathways constituting biomarkers for calcific aortic valve disease (CAVD), including extra-cellular matrix (ECM) alteration. ECM collagen deficiency and impact on heart valve structural integrity were confirmed by histopathology for high-level MBP exposure, and structural defects (abnormal curvature) of the atrio-ventricular valves corresponded with impaired cardiovascular function (reduced ventricular beat rate and blood flow). Our results are the first to demonstrate plausible mechanistic links between ERE activation in the heart valves by BPA\u2019s reactive metabolite MBP and the development of valvular-cardiovascular disease states.<\/jats:p>","DOI":"10.1021\/acs.est.8b04281","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T14:46:48Z","timestamp":1544107608000},"page":"463-474","source":"Crossref","is-referenced-by-count":67,"title":["Cardiovascular\nEffects and Molecular Mechanisms of\nBisphenol A and Its Metabolite MBP in Zebrafish"],"prefix":"10.1021","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3892-8993","authenticated-orcid":true,"given":"A. Ross","family":"Brown","sequence":"first","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon M.","family":"Green","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Moreman","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina M.","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulayman","family":"Mourabit","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Ball","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Winter","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Trznadel","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Correia","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hacker","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Perry","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Wood","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm J.","family":"Hetheridge","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Currie","sequence":"additional","affiliation":[{"name":"Jealott\u2019s Hill International Research Centre , Syngenta, , ,","place":["Bracknell, Berkshire, U.K., RG42 6EY"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Tyler","sequence":"additional","affiliation":[{"name":"University of Exeter , , Geoffrey Pope, Stocker Road , , ,","place":["Exeter, Devon, U.K., EX4 4QD"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"2026090312590135000_cit1","unstructured":"TEDX.\n          .  TEDX list of potential endocrine disruptors. 2018; (accessed 26 June 2018): https:\/\/endocrinedisruption.org\/interactive-tools\/tedx-list-of-potential-endocrine-disruptors\/."},{"key":"2026090312590135000_cit2","unstructured":"EC European Commission.\n          .  European workshop\non the impact of endocrine\ndisrupters on human health and wildlife. Weybridge, UK. 1996; (accessed 1 February 2018): http:\/\/www.iehconsulting.co.uk\/IEH_Consulting\/IEHCPubs\/EndocrineDisrupters\/WEYBRIDGE.pdf."},{"key":"2026090312590135000_cit3","unstructured":"WHO.\n          .  IPCS Global assessment of the state-of-the-science\nof endocrine\ndisruptors WHO\/PCS\/EDC\/02.2. 2002; (accessed 15 January 2017): http:\/\/www.who.int\/ipcs\/publications\/new_issues\/endocrine_disruptors\/en\/."},{"key":"2026090312590135000_cit4","unstructured":"WHO\/UNEP.\n          .  State of the science of endocrine disrupting\nchemicals\n\u2013 2012. An assessment of the state of the science of endocrine\ndisruptors prepared by a group of experts for the United Nations Environment\nProgramme (UNEP) and World Health Organisation (WHO). 2012; (accessed 15 January 2017): http:\/\/www.who.int\/ceh\/publications\/endocrine\/en\/."},{"key":"2026090312590135000_cit5","unstructured":"EEA European Environment Agency.\n          .  Impacts\nof endocrine disrupters on wildlife,\npeople and their environments. The Weybridge+15 (1996\u20132011)\nreport. EEA Technical report No 2\/2012, ISSN 1725-2237. 2012; (accessed\nMarch 2018): https:\/\/www.eea.europa.eu\/publications\/the-impacts-of-endocrine-disrupters."},{"key":"2026090312590135000_cit6","unstructured":"EC European Commission.\n          .  Endocrine disruptors,\nstrategy, what is\nbeing done, priority list. 2017; (accessed Jan\n2018): http:\/\/ec.europa.eu\/environment\/chemicals\/endocrine\/strategy\/being_en.htm."},{"key":"2026090312590135000_cit7","unstructured":"EPA Environmental Protection Agency.\n          .  Endocrine Disruption Screening\nProgram for the 21st Century Dashboard. 2017; (accessed 10 January 2018): https:\/\/actor.epa.gov\/edsp21\/."},{"key":"2026090312590135000_cit8","unstructured":"MOE, Ministry of the Environment - Government of Japan.\n          .  Endocrine Disrupting\nEffects of Substances. 2017; (accessed 2 November\n2017): http:\/\/www.env.go.jp\/en\/chemi\/ed.html."},{"issue":"3","key":"2026090312590135000_cit9","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1172\/JCI27987","article-title":"Estrogen receptors\nand human disease","volume":"116","author":"Deroo","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2026090312590135000_cit10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/annurev.physiol.66.032802.154945","article-title":"Estrogens\nin the nervous system:\nmechanisms and nonreproductive functions","volume":"66","author":"Maggi","year":"2004","journal-title":"Annu. Rev. Physiol."},{"issue":"7","key":"2026090312590135000_cit11","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.tem.2009.03.009","article-title":"Endocrine disruptors\nin female reproductive tract development and carcinogenesis","volume":"20","author":"Ma","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"2026090312590135000_cit12","unstructured":"EC European Commission.\n          .  4th Report on the implementation of the\n\u2033Community Strategy for Endocrine Disrupters\u2033 a range\nof substances suspected of interfering with the hormone systems of\nhumans and wildlife (COM (1999) 706). Commission staff working\npaper SEC (2011) 1001 final, Brussels. http:\/\/ec.europa.eu\/environment\/chemicals\/endocrine\/documents\/index_en.htm#SubThemes2 (accessed 1 February 2018)."},{"key":"2026090312590135000_cit13","unstructured":"Kortenkamp, A.; Martin, O.; Faust, M.; Evans, R.; McKinlay, R.; Orton, F.; Rosivatz, E.\n          State of the art assessment of endocrine\ndisrupters. Final Report to the European Commission Project\nContract Number 070307\/2009\/550687\/SER\/D3. 2011; URL (accessed March 2018): http:\/\/ec.europa.eu\/environment\/chemicals\/endocrine\/pdf\/sota_edc_final_report.pdf."},{"issue":"6","key":"2026090312590135000_cit14","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1161\/CIRCRESAHA.110.236687","article-title":"Estrogen signalling\nand cardiovascular disease","volume":"109","author":"Murphy","year":"2011","journal-title":"Circ. Res."},{"key":"2026090312590135000_cit15","unstructured":"MRC, Merchant Research & Consulting.\n          .  Bisphenol A (BPA): 2014\nWorld Market Outlook and Forecast up to 2018. Market Publishers Ltd. 2014; (accessed\n7 December 2017): http:\/\/www.prweb.com\/releases\/2014\/04\/prweb11761146.htm."},{"issue":"1","key":"2026090312590135000_cit16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1289\/ehp.10753","article-title":"Exposure of the U.S. population\nto bisphenol A and 4-tertiary-octylphenol: 2003\u20132004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"2026090312590135000_cit17","unstructured":"US NTP-CERHR - National Toxicology Program.\n          \n          Center for the Evaluation\nof Risks to Human Reproduction. NTP-CERHR Monograph on the potential\nhuman reproductive and developmental effects of bisphenol A; 2008. NIH Publication no: 80\u20135994. URL (accessed 20 April 2018): www.cerhr.niehs.nih.gov\/chemicals\/bisphenol\/bisphenol.pdf."},{"issue":"1","key":"2026090312590135000_cit18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008673","article-title":"Association of urinary bisphenol\na concentration with heart disease: evidence from NHANES 2003\/06","volume":"5","author":"Melzer","year":"2010","journal-title":"PLoS One"},{"key":"2026090312590135000_cit19","unstructured":"FAO\/WHO Food and Agriculture Organisation\/World Health Organisation.\n          .  Joint FAO\/WHO expert meeting to review toxicological and health aspects\nof bisphenol A: final report, including report of stakeholder meeting\non bisphenol A, 1\u20135 November 2010, Ottawa, Canada. Publ. WHO, Geneva, Switzerland, 2011 (accessed 1 September 2016): http:\/\/apps.who.int\/iris\/bitstream\/10665\/44624\/1\/97892141564274_eng.pdf?ua=1."},{"issue":"8","key":"2026090312590135000_cit20","doi-asserted-by":"publisher","first-page":"5711","DOI":"10.1007\/s11356-014-3974-5","article-title":"nonylphenols,\nbenzophenones, and benzotriazoles in soils, groundwater, surface water,\nsediments, and food: a review","volume":"22","author":"Careghini","year":"2015","journal-title":"Environ. Sci.\nPollut. Res."},{"key":"2026090312590135000_cit21","unstructured":"EFSA, CEF Panel (EFSA Panel on Food Contact Materials.\n          \n          Enzymes,\nFlavourings and Processing Aids). Draft Scientific Opinion on the\nrisks to public health related to the presence of bisphenol A (BPA)\nin foodstuffs. European Food Safety Authority (EFSA), Parma, Italy. 2014; (accessed 1 September\n2016): https:\/\/www.efsa.europa.eu\/sites\/default\/files\/consultation\/140117.pdf."},{"issue":"1","key":"2026090312590135000_cit22","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.2903\/j.efsa.2015.3978","article-title":"EFSA, CEF Panel (EFSA Panel on Food Contact\nMaterials, Enzymes, Flavourings\nand Processing Aids). Scientific Opinion on the risks to public health\nrelated to the presence of bisphenol A (BPA) in foodstuffs: executive\nsummary","volume":"13","year":"2015","journal-title":"EFSA J."},{"issue":"3","key":"2026090312590135000_cit23","doi-asserted-by":"publisher","first-page":"155932581559830","DOI":"10.1177\/1559325815598308","article-title":"Global assessment\nof bisphenol A in the environment: review and analysis of its occurrence\nand bioaccumulation","volume":"13","author":"Corrales","year":"2015","journal-title":"Dose-Response"},{"key":"2026090312590135000_cit24","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1289\/ehp.5494","article-title":"Large effects\nfrom small exposures. I. Mechanisms for endocrine-disrupting chemicals\nwith estrogenic activity","volume":"111","author":"Welshons","year":"2003","journal-title":"Environ. Health\nPerspect."},{"issue":"1","key":"2026090312590135000_cit25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1289\/ehp.10587","article-title":"Direct evidence\nrevealing structural\nelements essential for the high binding ability of bisphenol A to\nhuman estrogen-related receptor-gamma","volume":"116","author":"Okada","year":"2008","journal-title":"Environ.\nHealth Perspect."},{"issue":"7","key":"2026090312590135000_cit26","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.1096\/fj.13-240465","article-title":"Estrogen-related\nreceptor \u03b3 is an in vivo receptor of bisphenol A","volume":"28","author":"Tohme\u0301","year":"2014","journal-title":"FASEB J."},{"issue":"4","key":"2026090312590135000_cit27","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1289\/ehp.7505","article-title":"Xenoestrogens\nat picomolar to nanomolar concentrations trigger membrane estrogen\nreceptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3\/B6\npituitary tumor cells","volume":"113","author":"Wozniak","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"2026090312590135000_cit28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.taap.2012.12.014","article-title":"Bisphenol A at a low concentration\nboosts mouse spermatogonial cell proliferation by inducing the G protein-coupled\nreceptor expression","volume":"267","author":"Sheng","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2026090312590135000_cit29","doi-asserted-by":"crossref","unstructured":"Bromer, J. G.; Zhou, Y.; Taylor, M. B.; Doherty, L.; Taylor, H. S.\n          Bisphenol-A\nexposure in utero leads to epigenetic alterations in the developmental\nprogramming of uterine estrogen response.  FASEB J.. 2010, 24(7), 2273\u20132280. PMID:\n20181937.","DOI":"10.1096\/fj.09-140533"},{"issue":"7","key":"2026090312590135000_cit30","doi-asserted-by":"publisher","first-page":"7537","DOI":"10.3390\/ijerph110707537","article-title":"Bisphenol-A: epigenetic\nreprogramming and effects on reproduction and behavior","volume":"11","author":"Mileva","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"2026090312590135000_cit31","doi-asserted-by":"publisher","first-page":"5185","DOI":"10.1210\/jc.2002-020209","article-title":"Thyroid hormone action is disrupted by bisphenol\nA as an antagonist","volume":"87","author":"Moriyama","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"2026090312590135000_cit32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/toxsci\/kfg150","article-title":"Antiandrogenic effects of bisphenol\nA and nonylphenol on the function of androgen receptor","volume":"75","author":"Lee","year":"2003","journal-title":"Toxicol. Sci."},{"key":"#cr-split#-2026090312590135000_cit33.1","unstructured":"US EPA (Environmental Protection Agency).  . Bisphenol A (CASRN 80-05-7) Action Plan, 3\/29\/2010, 2010"},{"key":"#cr-split#-2026090312590135000_cit33.2","unstructured":"(accessed 20 April 2018): https:\/\/www.epa.gov\/sites\/production\/files\/2015-09\/documents\/bpa_action_plan.pdf."},{"key":"2026090312590135000_cit34","unstructured":"EC JRC, European Commission Joint Research Centre.\n          .  Summary dossier\nreview: Bisphenol A-DRAFT-JRC-2015, 2015; (accessed\n30 November 2017): https:\/\/circabc.europa.eu\/\u00b7\u00b7\u00b7\/Summary%20dossier%20review_Bisphenol%20A-DRAFT."},{"key":"2026090312590135000_cit35","unstructured":"Health Canada.\n          .  Bisphenol A: Update on the\nFood Directorate\u2019s risk\nmanagement commitments for infant formula. December 15, 2014; (accessed 1 December 2017): http:\/\/www.hc-sc.gc.ca\/fn-an\/alt_formats\/pdf\/securit\/packag-emball\/bpa\/bpa-formula-nourrissons-eng.pdf."},{"key":"2026090312590135000_cit36","unstructured":"FDA Food and Drug Administration.\n          .  Update\non Bisphenol A (BPA) for Use in Food\nContact Applications, Updated November 2014; (accessed 1\nSeptember 2016): http:\/\/www.fda.gov\/food\/ingredientspackaginglabeling\/foodadditivesingredients\/ucm064437.htm."},{"key":"#cr-split#-2026090312590135000_cit37.1","unstructured":"Health Canada.  . Significant New Activity Notice No. 15290 (Section 85 of the Canadian Environmental Protection Act, 1999) Publication of final decision on the screening assessment of a substance - Phenol, 4,4'-(1-methylethylidene)bis-(bisphenol A),CASNo. 80-05-7 - specified on the Domestic Substances List [subsection 77(6) of the Canadian Environmental Protection Act, 1999]"},{"key":"#cr-split#-2026090312590135000_cit37.2","unstructured":"(accessed 7 November 2017): www.canadagazette.gc.ca\/partI\/2008\/20081018\/html\/notice-e.html#d101."},{"key":"#cr-split#-2026090312590135000_cit37.3","unstructured":"Health Canada.  . Significant New Activity Notice No. 15290 (Section 85 of the Canadian Environmental Protection Act, 1999) Publication of final decision on the screening assessment of a substance - Phenol, 4,4'-(1-methylethylidene)bis-(bisphenol A),CASNo. 80-05-7 - specified on the Domestic Substances List [subsection 77"},{"key":"#cr-split#-2026090312590135000_cit37.4","unstructured":"(6) of the Canadian Environmental Protection Act, 1999]; Canada Gazette2008;142(42), ; (accessed 7 November 2017): www.canadagazette.gc.ca\/partI\/2008\/20081018\/html\/notice-e.html#d101."},{"key":"2026090312590135000_cit38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.chemosphere.2016.05.070","article-title":"From\nBPA to its analogues:\nIs it a safe journey?","volume":"158","author":"Usman","year":"2016","journal-title":"Chemosphere"},{"issue":"21","key":"2026090312590135000_cit39","doi-asserted-by":"publisher","first-page":"12796","DOI":"10.1021\/acs.est.7b03283","article-title":"Acute toxicity, teratogenic, and estrogenic\neffects\nof bisphenol A and its alternative replacements bisphenol S, bisphenol\nF, and bisphenol AF in zebrafish embryo-larvae","volume":"51","author":"Moreman","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"2026090312590135000_cit40","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1093\/toxsci\/kfh047","article-title":"Potent estrogenic metabolites\nof bisphenol a and bisphenol b formed by rat liver s9 fraction: their\nstructures and estrogenic potency","volume":"78","author":"Yoshihara","year":"2004","journal-title":"Toxicol.\nSci."},{"key":"2026090312590135000_cit41","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.toxlet.2010.04.017","article-title":"In vivo estrogenic potential of 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene,\nan active metabolite of bisphenol A, in uterus of ovariectomized rat","volume":"197","author":"Okuda","year":"2010","journal-title":"Toxicol. Lett."},{"key":"2026090312590135000_cit42","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.aquatox.2004.12.011","article-title":"Short-term\neffects of endocrine-disrupting\nchemicals on the expression of estrogen-responsive genes in male medaka\n(Oryzias latipes)","volume":"72","author":"Yamaguchi","year":"2005","journal-title":"Aquat.\nToxicol."},{"key":"2026090312590135000_cit43","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1016\/j.lfs.2005.03.025","article-title":"Toxicity to early life stages\nand\nan estrogenic effect of a bisphenol A metabolite, 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene\non the medaka (Oryzias latipes)","volume":"77","author":"Ishibashi","year":"2005","journal-title":"Life Sci."},{"issue":"11","key":"2026090312590135000_cit44","doi-asserted-by":"publisher","first-page":"6656","DOI":"10.1021\/acs.est.8b01095","article-title":"Estrogenic mechanisms and cardiac\nresponses following early life exposure to Bisphenol A (BPA) and its\nmetabolite 4-methyl-2,4-bis(p-hydroxyphenyl)pent-1-ene (MBP) in zebrafish","volume":"52","author":"Moreman","year":"2018","journal-title":"Environ. 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