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We quantified the influence of a residential lead hazard intervention and dust control on children\u2019s urinary phthalate metabolite concentrations. Between 2003 and 2006, The Health Outcomes and Measures of the Environment (HOME) Study randomized 355 pregnant women to receive an intervention to reduce either residential lead or injury hazards before delivery. We quantified eight urinary phthalate metabolites from 288 children at ages 1, 2, or 3 years (680 observations). During yearly home visits, we assessed dust accumulation in housing units. Children in the lead intervention group had 11\u201312% lower concentrations of the sum of di\u00ad(2-ethylhexyl) phthalate metabolites, monocarboxyoctyl phthalate, and monocarboxynonyl phthalate compared to the injury intervention group. Monoethyl phthalate concentrations did not differ by group. In observational analyses, children living in housing units that appeared clean had 12\u201317% lower concentrations of these phthalate metabolites and monobenzyl phthalate, compared to children living in housing units with more dust accumulation. Features of this lead hazard intervention and measures to control dust may reduce children\u2019s exposure to phthalates found in building materials and household furnishings.<\/jats:p>","DOI":"10.1021\/acs.est.9b04898","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T15:51:22Z","timestamp":1582732282000},"page":"4327-4335","source":"Crossref","is-referenced-by-count":19,"title":["Lowering\nUrinary Phthalate Metabolite Concentrations\namong Children by Reducing Contaminated Dust in Housing Units: A Randomized\nControlled Trial and Observational Study"],"prefix":"10.1021","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-4077","authenticated-orcid":true,"given":"Clara G.","family":"Sears","sequence":"first","affiliation":[{"name":"Brown University , , , ,","place":["Providence, Rhode Island, United States, 02912"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce P.","family":"Lanphear","sequence":"additional","affiliation":[{"name":"Simon Fraser University , , , ,","place":["Burnaby, BC, Canada, V5A 1S6"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia M.","family":"Calafat","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , , ,","place":["Atlanta, Georgia, United States, 30329"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine , , , ,","place":["Cincinnati, Ohio, United States, 45267"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne","family":"Skarha","sequence":"additional","affiliation":[{"name":"Brown University , , , ,","place":["Providence, Rhode Island, United States, 02912"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Xu","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine , , , ,","place":["Cincinnati, Ohio, United States, 45267"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Yolton","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center , , , ,","place":["Cincinnati, Ohio, United States, 45229"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Braun","sequence":"additional","affiliation":[{"name":"Brown University , , , ,","place":["Providence, Rhode Island, United States, 02912"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"issue":"8","key":"2026081715250183100_cit1","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.1021\/acs.est.5b05906","article-title":"Tracking SVOCs\u2019\nTransfer from Products to Indoor Air and Settled Dust with Deuterium-Labeled\nSubstances","volume":"50","author":"Sukiene","year":"2016","journal-title":"Environ. 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Health"},{"issue":"14","key":"2026081715250183100_cit3","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1289\/ehp.7187","article-title":"The Association\nbetween Asthma and Allergic Symptoms in Children and Phthalates in\nHouse Dust: A Nested Case-Control Study","volume":"112","author":"Bornehag","year":"2004","journal-title":"Environ.\nHealth Perspect."},{"issue":"1","key":"2026081715250183100_cit4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s12940-015-0024-9","article-title":"Phthalate\nConcentrations in House Dust in Relation\nto Autism Spectrum Disorder and Developmental Delay in the CHildhood\nAutism Risks from Genetics and the Environment (CHARGE) Study","volume":"14","author":"Philippat","year":"2015","journal-title":"Environ. 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Chromatogr. B: Anal. Technol.\nBiomed. Life Sci."},{"key":"2026081715250183100_cit21","unstructured":"Centers for\nDisease Control\nand Prevention\n          . National Report on\nHuman Exposure to Environmental Chemicals; January 2019 Updated\nTables. https:\/\/www.cdc.gov\/exposurereport\/ (accessed Nov 26, 2019)."},{"key":"2026081715250183100_cit22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.scitotenv.2013.07.107","article-title":"Associations of Phthalate Concentrations in\nFloor Dust and Multi-Surface Dust with the Interior Materials in Japanese\nDwellings","volume":"468\u2013469","author":"AitBamai","year":"2014","journal-title":"Sci. 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Sci. Technol."},{"issue":"4","key":"2026081715250183100_cit31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062442","article-title":"Children\u2019s Phthalate\nIntakes and Resultant Cumulative\nExposures Estimated from Urine Compared with Estimates from Dust Ingestion,\nInhalation and Dermal Absorption in Their Homes and Daycare Centers","volume":"8","author":"Beko\u0308","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"2026081715250183100_cit32","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1021\/es2002106","article-title":"Comparative Assessment of Human Exposure to Phthalate\nEsters from House Dust in China and the United States","volume":"45","author":"Guo","year":"2011","journal-title":"Environ. Sci. 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Environ."},{"key":"2026081715250183100_cit35","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.scitotenv.2018.07.127","article-title":"Electronics,\nInterior Decoration and Cleaning Patterns Affect Flame Retardant Levels\nin the Dust from Dutch Residences","volume":"645","author":"Sugeng","year":"2018","journal-title":"Sci. Total\nEnviron."},{"issue":"1","key":"2026081715250183100_cit36","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1039\/B807821A","article-title":"Evaluation of HEPA\nVacuum Cleaning and Dry Steam Cleaning in Reducing Levels of Polycyclic\nAromatic Hydrocarbons and House Dust Mite Allergens in Carpets","volume":"11","author":"Yu","year":"2009","journal-title":"J. Environ. Monit."},{"issue":"10","key":"2026081715250183100_cit37","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1289\/ehp.7809","article-title":"Phthalates in Indoor\nDust and Their\nAssociation with Building Characteristics","volume":"113","author":"Bornehag","year":"2005","journal-title":"Environ.\nHealth Perspect."},{"key":"2026081715250183100_cit38","unstructured":"IARC\n(International Agency\nfor Research on Cancer)\n          . A\nreview of human carcinogens. Part F: chemical agents and related occupations. https:\/\/monographs.iarc.fr\/ (accessed Jun 10, 2019)."},{"issue":"3","key":"2026081715250183100_cit39","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1289\/ehp.6723","article-title":"Urinary\nLevels of Seven Phthalate Metabolites in the U.S. Population from\nthe National Health and Nutrition Examination Survey (NHANES) 1999\u20132000","volume":"112","author":"Silva","year":"2004","journal-title":"Environ. 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