{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:56:26Z","timestamp":1782453386415,"version":"3.54.5"},"reference-count":100,"publisher":"American Chemical Society (ACS)","issue":"16","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bodossakis Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ind. Eng. Chem. Res."],"published-print":{"date-parts":[[2025,4,23]]},"DOI":"10.1021\/acs.iecr.4c04540","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T04:47:56Z","timestamp":1744606076000},"page":"8064-8078","source":"Crossref","is-referenced-by-count":3,"title":["Esterification of Levulinic Acid to Ethyl Levulinate over Amberlyst-15 in Flow: Systematic Kinetic Model Discrimination and Parameter Estimation"],"prefix":"10.1021","volume":"64","author":[{"given":"Eleni","family":"Grammenou","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maerthe Theresa","family":"Tillmann","sequence":"additional","affiliation":[{"name":"Faculty of Mechanical Engineering, RWTH Aachen University, Elifschornsteinstra\u00dfe 18, 52062 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon Gajere","family":"Bawa","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Pankajakshan","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3296-1581","authenticated-orcid":true,"given":"Federico","family":"Galvanin","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-5043","authenticated-orcid":true,"given":"Asterios","family":"Gavriilidis","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eti.2021.102080"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2006.03.031"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s12649-020-01221-z"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/B978-0-08-100135-6.00005-3","volume-title":"Lignocellulose Biorefinery Engineering","author":"Chen H.","year":"2015"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/c3gc41492b"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00794"},{"key":"ref7\/cit7","unstructured":"Levulinic acid market size and share analysis by\ntechnology (biofine,\nacid hydrolysis), application (food additives, pharmaceuticals, agricultural\nproducts, personal care products, plasticizers, fuel additives) -\nglobal industry growth forecast to 2030, 2022; p 170."},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/ese3.1320"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1515\/chem-2018-0070"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.combustflame.2018.02.028"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.15376\/biores.7.4.5972-5982"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s11144-011-0364-6"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/C6GC01523A"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcata.2012.03.020"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2011.12.004"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2013.01.010"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2013.10.006"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/cs5008393"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcata.2014.02.032"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.renene.2020.05.103"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcata.2013.04.024"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/jctb.4228"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2014.01.013"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s11244-018-0998-y"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200462544"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.coche.2013.05.004"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjche.2021.08.023"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/op100300p"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2021.04.001"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.5b00184"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cattod.2016.06.007"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00037"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C7RE00026J"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.9b04089"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/cmtd.202200049"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/op3001838"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/C6RE00007J"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/C9RE00180H"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/C9RE00342H"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/D0RE00304B"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127017"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1039\/D1RE00098E"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC00859E"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C8RE00037A"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/D0RE00191K"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00202"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201101803"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01059F"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcat.2021.08.013"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1039\/b919544k"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1039\/C7RE00163K"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201306468"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1039\/D1RE00350J"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC03728G"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1186\/s12918-017-0428-y"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cherd.2021.12.028"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2020.115974"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/ceat.201500733"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/ie070309s"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.cep.2010.07.007"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.2516\/ogst\/2009079"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2021.116667"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jala.2006.07.012"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2017.04.059"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.compchemeng.2019.01.010"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1515\/ijcre-2014-0068"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.fuel.2022.124362"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/kin.20841"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2004.04.003"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/s13369-017-2927-y"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3184\/146867809X12583840521552"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b02994"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2008.10.062"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.15255\/CABEQ.2014.2083"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2017.1291672"},{"key":"ref76\/cit76","unstructured":"Montgomery, D. C. Design and Analysis of Experiments, 8th ed. John Wiley & Sons, Inc: Hoboken, NJ, 2013; p 730."},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1979.10489755"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1967.10490441"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1978.10489611"},{"key":"ref80\/cit80","doi-asserted-by":"crossref","unstructured":"Draper, N. R.; Smith, H. Applied Regression Analysis, 3rd ed. Wiley: New York, 1998; p 706.","DOI":"10.1002\/9781118625590"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2007.11.034"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/i360002a016"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1002\/polc.5070160323"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.06.083"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1007\/s13203-020-00244-w"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1080\/00986445.2015.1107720"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1021\/ie9708790"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1021\/ie000063q"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-849876-7.00006-3"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1021\/ie402407r"},{"key":"ref91\/cit91","first-page":"79","volume":"28","author":"Sharma M.","year":"2014","journal-title":"Chem. Biochem. Eng. Q."},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1021\/ie301661n"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690140124"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690210115"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.26405"},{"key":"ref96\/cit96","volume-title":"Principles of Polymer Chemistry","author":"Flory P. J.","year":"1953"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1021\/ie960450t"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1021\/ie030664s"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.fluid.2004.01.020"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.0c05027"}],"container-title":["Industrial & Engineering Chemistry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.iecr.4c04540","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.iecr.4c04540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:13:49Z","timestamp":1745396029000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.iecr.4c04540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":100,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,4,23]]}},"alternative-id":["10.1021\/acs.iecr.4c04540"],"URL":"https:\/\/doi.org\/10.1021\/acs.iecr.4c04540","relation":{},"ISSN":["0888-5885","1520-5045"],"issn-type":[{"value":"0888-5885","type":"print"},{"value":"1520-5045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]}}}