{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:49:41Z","timestamp":1785941381580,"version":"3.56.0"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["2021.05666.BD"],"award-info":[{"award-number":["2021.05666.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0045\/2020"],"award-info":[{"award-number":["LA\/P\/0045\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/50020\/2025"],"award-info":[{"award-number":["UID\/50020\/2025"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["2021.05666.BD"],"award-info":[{"award-number":["2021.05666.BD"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This work evaluated the feasibility of the simulated moving bed (SMB) technology to fractionate volatile fatty acids produced through wastewater acidogenic fermentation. A lab-scale SMB unit equipped with 6 columns (FlexSMB), each packed with a nonfunctionalized resin (Amberlite XAD-4), was used to separate a binary solution of acetic and propanoic acids, for proof of concept. SMB operating conditions were first determined by building the separation region for a limit purity of 95% in both extract and raffinate streams, and a 1\u20132\u20132\u20131 column configuration. The process accomplished the separation of acetic and propanoic acids in the raffinate and extract streams, with purities of 97.8% and 100.0%, and recoveries of 100.0% and 97.8%, respectively. Productivities reached 2.93 and 2.81 mmol\u00b7gads\u20131.day\u20131 in the raffinate and extract streams, respectively. An eluent consumption of 0.075 L\u00b7mmol\u20131 was attained. The mathematical model proposed accurately described the experimental data. Overall, SMB technology showed strong potential for efficient VFA fractionation.<\/jats:p>","DOI":"10.1021\/acs.iecr.6c02420","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:24:27Z","timestamp":1784575467000},"page":"16249-16257","source":"Crossref","is-referenced-by-count":0,"title":["Separation of Volatile\nFatty Acids by Simulated Moving\nBed"],"prefix":"10.1021","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5231-8486","authenticated-orcid":true,"given":"Cristiana","family":"Gomes","sequence":"first","affiliation":[{"name":"University of Porto , , Rua Dr. Roberto Frias , ,","place":["Porto, Portugal, 4200-465"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4269-1420","authenticated-orcid":true,"given":"Ana M.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"University of Porto , , Rua Dr. Roberto Frias , ,","place":["Porto, Portugal, 4200-465"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0715-4761","authenticated-orcid":true,"given":"Ali\u0301rio E.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"University of Porto , , Rua Dr. Roberto Frias , ,","place":["Porto, Portugal, 4200-465"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6746-8973","authenticated-orcid":true,"given":"Alexandre F. P.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"University of Porto , , Rua Dr. Roberto Frias , ,","place":["Porto, Portugal, 4200-465"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026080510071341300_cit1","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.biortech.2018.07.042","article-title":"Bio-based\nvolatile fatty acid production and recovery from waste streams: Current\nstatus and future challenges","volume":"268","author":"Atasoy","year":"2018","journal-title":"Bioresour. Technol."},{"issue":"2","key":"2026080510071341300_cit2","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation3020022","article-title":"Biochemical\nProduction and Separation\nof Carboxylic Acids for Biorefinery Applications","volume":"3","author":"Murali","year":"2017","journal-title":"Fermentation"},{"key":"2026080510071341300_cit3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jiec.2019.09.009","article-title":"Feasibility\nof membrane processes for the recovery and purification of bio-based\nvolatile fatty acids: A comprehensive review","volume":"81","author":"Aghapour Aktij","year":"2020","journal-title":"J. Ind. Eng. Chem."},{"key":"2026080510071341300_cit4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/14356007.a05_235.pub2","article-title":"Carboxylic Acids,\nAliphatic","volume-title":"Ullmann\u2019s Encyclopedia\nof Industrial Chemistry","author":"Kubitschke","year":"2014"},{"issue":"1","key":"2026080510071341300_cit5","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1080\/21655979.2021.1996044","article-title":"A Glimpse\nof the World of Volatile Fatty Acids Production and Application: A\nreview","volume":"13","author":"Agnihotri","year":"2022","journal-title":"Bioengineered"},{"issue":"19","key":"2026080510071341300_cit6","doi-asserted-by":"publisher","first-page":"9248","DOI":"10.1021\/ie100330y","article-title":"Evaluation of Ion-Exchange and Adsorbent\nResins for the Detoxification of Beet Distillery Effluents","volume":"49","author":"Fargues","year":"2010","journal-title":"Ind. Eng. Chem. Res."},{"key":"2026080510071341300_cit7","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1080\/01496395.2019.1600553","article-title":"Volatile fatty\nacid adsorption on anion exchange resins: kinetics and selective recovery\nof acetic acid","volume":"55","author":"Eregowda","year":"2019","journal-title":"Sep. Sci. Technol."},{"key":"2026080510071341300_cit8","first-page":"1","article-title":"Principles of Simulated Moving\nBed","volume-title":"Simulated Moving Bed Technology","author":"Rodrigues","year":"2015"},{"key":"2026080510071341300_cit9","first-page":"568","article-title":"Adsorption,\nIon Exchange, Chromatography, and Electrophoresis","volume-title":"Separation Process Principles: Chemical and Biochemical\nOperations","author":"Seader","year":"2011"},{"key":"2026080510071341300_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2019.116368","article-title":"Recovery and\npurification of acetic acid from aqueous mixtures by simulated moving\nbed adsorption with methanol and water as desorbents","volume":"237","author":"Uribe Santos","year":"2020","journal-title":"Sep. Purif. Technol."},{"issue":"1","key":"2026080510071341300_cit11","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1021\/acs.iecr.1c03388","article-title":"Recovery of a Succinic,\nFormic, and Acetic Acid Mixture from a Model Fermentation Broth by\nSimulated Moving Bed Adsorption with Methanol as a Desorbent","volume":"61","author":"Uribe Santos","year":"2022","journal-title":"Ind. Eng. Chem. Res."},{"issue":"1","key":"2026080510071341300_cit12","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1021\/bp025663u","article-title":"Separation of lactic acid from acetic\nacid using a four-zone SMB","volume":"20","author":"Lee","year":"2008","journal-title":"Biotechnol. Prog."},{"key":"2026080510071341300_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2024.121062","article-title":"A review of volatile\nfatty acids\nproduction from organic wastes: Intensification techniques and separation\nmethods","volume":"360","author":"Sun","year":"2024","journal-title":"J. Environ. 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Eng. Technol."},{"key":"2026080510071341300_cit18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.chroma.2018.05.052","article-title":"Separation of tartronic and glyceric acids by simulated\nmoving bed chromatography","volume":"1563","author":"Coelho","year":"2018","journal-title":"J. Chromatogr. A"},{"issue":"35","key":"2026080510071341300_cit19","doi-asserted-by":"publisher","first-page":"13932","DOI":"10.1021\/acs.iecr.3c01613","article-title":"Bovine Serum\nAlbumin and Myoglobin Separation by Ion-Exchange SMB","volume":"62","author":"Rios","year":"2023","journal-title":"Ind. Eng. Chem. Res."},{"key":"2026080510071341300_cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2023.124779","article-title":"Bovine\nserum albumin and myoglobin separation on HAp","volume":"326","author":"Rios","year":"2023","journal-title":"Sep. Purif. 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Food Eng."},{"key":"2026080510071341300_cit24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/B978-0-12-802024-1.00002-1","article-title":"Modeling and Simulation\nof Simulated Moving Bed Separation Processes","volume-title":"Simulated Moving Bed Technology","author":"Rodrigues","year":"2015"},{"key":"2026080510071341300_cit25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/9780470988428.ch7","article-title":"Simulated Moving\nBed and Related Techniques","volume-title":"Preparative\nEnantioselective Chromatography","author":"Pais","year":"2005"},{"key":"2026080510071341300_cit26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/B978-0-12-802024-1.00003-3","article-title":"Design of Simulated\nMoving Bed for Binary or Pseudo-Binary Separations","volume-title":"Simulated Moving Bed Technology","author":"Rodrigues","year":"2015"},{"issue":"10","key":"2026080510071341300_cit27","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/aic.10532","article-title":"Simulated\nmoving-bed reactor: Reactive\u2013separation\nregions","volume":"51","author":"Minceva","year":"2005","journal-title":"AIChE J."},{"issue":"4","key":"2026080510071341300_cit28","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1021\/ie020863w","article-title":"Designs of Simulated-Moving-Bed\nCascades for Quaternary\nSeparations","volume":"43","author":"Kim","year":"2004","journal-title":"Ind. Eng. Chem. Res."},{"issue":"26","key":"2026080510071341300_cit29","doi-asserted-by":"publisher","first-page":"6185","DOI":"10.1021\/ie010075r","article-title":"Simulated\nMoving Bed Cascades for Ternary Separations","volume":"40","author":"Wankat","year":"2001","journal-title":"Ind. Eng. Chem. Res."}],"container-title":["Industrial &amp; Engineering\nChemistry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.iecr.6c02420","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/iecred\/article-pdf\/65\/30\/16249\/66067744\/acs.iecr.6c02420.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/iecred\/article-pdf\/65\/30\/16249\/66067744\/acs.iecr.6c02420.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:10:45Z","timestamp":1785939045000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/iecred\/article\/65\/30\/16249\/5222578\/Separation-of-Volatile-Fatty-Acids-by-Simulated"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":29,"journal-issue":{"issue":"30","published-online":{"date-parts":[[2026,7,20]]},"published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.iecr.6c02420","relation":{},"ISSN":["0888-5885","1520-5045"],"issn-type":[{"value":"0888-5885","type":"print"},{"value":"1520-5045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]}}}