{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:11:53Z","timestamp":1793747513766,"version":"4.6.1"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CM1006"],"award-info":[{"award-number":["CM1006"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["TD1004"],"award-info":[{"award-number":["TD1004"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["TD1007"],"award-info":[{"award-number":["TD1007"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["TD1402"],"award-info":[{"award-number":["TD1402"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Walloon Region"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inorg. Chem."],"published-print":{"date-parts":[[2021,3,15]]},"DOI":"10.1021\/acs.inorgchem.0c03120","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T18:34:32Z","timestamp":1614191672000},"page":"3604-3619","source":"Crossref","is-referenced-by-count":42,"title":["Mn<sup>2+<\/sup> Complexes with Pyclen-Based Derivatives as Contrast Agents for Magnetic Resonance Imaging: Synthesis and Relaxometry Characterization"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9060-4921","authenticated-orcid":true,"given":"Marie","family":"Devreux","sequence":"first","affiliation":[{"name":"General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 7000 Mons, Belgium"},{"name":"University of Bordeaux, CNRS, Bordeaux INP, ENSCBP, Laboratory of Organic Polymer Chemistry (LCPO), 33607 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Henoumont","sequence":"additional","affiliation":[{"name":"General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 7000 Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-6657","authenticated-orcid":true,"given":"Fabienne","family":"Dioury","sequence":"additional","affiliation":[{"name":"Conservatoire National des Arts et M\u00e9tiers (CNAM), GBCM Laboratory, HESAM Universit\u00e9, EA 7528, 2 rue Cont\u00e9, 75003 Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Boutry","sequence":"additional","affiliation":[{"name":"Center for Microscopy and Molecular Imaging (CMMI), 8 rue Adrienne Bolland, 6041 Charleroi, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Vacher","sequence":"additional","affiliation":[{"name":"Conservatoire National des Arts et M\u00e9tiers (CNAM), GBCM Laboratory, HESAM Universit\u00e9, EA 7528, 2 rue Cont\u00e9, 75003 Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luce Vander","family":"Elst","sequence":"additional","affiliation":[{"name":"General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 7000 Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Port","sequence":"additional","affiliation":[{"name":"Conservatoire National des Arts et M\u00e9tiers (CNAM), GBCM Laboratory, HESAM Universit\u00e9, EA 7528, 2 rue Cont\u00e9, 75003 Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Muller","sequence":"additional","affiliation":[{"name":"General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 7000 Mons, Belgium"},{"name":"Center for Microscopy and Molecular Imaging (CMMI), 8 rue Adrienne Bolland, 6041 Charleroi, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1815-2702","authenticated-orcid":true,"given":"Olivier","family":"Sandre","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS, Bordeaux INP, ENSCBP, Laboratory of Organic Polymer Chemistry (LCPO), 33607 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Laurent","sequence":"additional","affiliation":[{"name":"General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 7000 Mons, Belgium"},{"name":"Center for Microscopy and Molecular Imaging (CMMI), 8 rue Adrienne Bolland, 6041 Charleroi, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00363"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002338"},{"key":"ref3\/cit3","first-page":"583","volume":"88","author":"Beam AS","year":"2017","journal-title":"Radiol. Technol."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.07.076"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2018-0608"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a4615"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142690"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201801220"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1097\/rli.0000000000000181"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017162857"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201101336"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.116"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.931"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-015-0056-x"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/srep39449"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3790"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-013-1074-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.178.1.1898538"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.100"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30661-w"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196998"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1521-3773(20000218)39:4<747::aid-anie747>3.0.co;2-2"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c04387"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/c4cc01251h"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202003685"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c03496"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2006.10.024"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2009.06.117"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ic201935r"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201800066"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201900387"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00232"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1021\/jacs.9b09407","volume":"142","author":"Bot\u00e1r R.","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ja4094132"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics6040116"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1063\/1.1701321"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1103\/physrev.99.559"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1063\/1.1743771"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1063\/1.1731684"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/9781118503652","volume-title":"The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging","author":"Merbach A. S.","year":"2013","edition":"2"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.388"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1039\/c5cs00055f"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200102000-00008"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.122812"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-010-0662-x"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1522-2675(20000216)83:2<394::aid-hlca394>3.0.co;2-b"},{"key":"ref47\/cit47","unstructured":"Note:\nChemicalize was used for prediction of p Kas and speciation curves (December, 2019; https:\/\/chemicalize.com\/, developed\nby ChemAxon): at highly acidic pH < 1, species charged +3 and +4\nare predominant for compound 16a (85, and 15% respectively\nat pH 0.7); at pH 4.5 (chromatographied solution), species charged\n+1, neutral, and charged +2 are predominant for compound 16a (73, 15, and 12% respectively)."}],"container-title":["Inorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.inorgchem.0c03120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T21:16:30Z","timestamp":1682630190000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.inorgchem.0c03120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,24]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3,15]]}},"alternative-id":["10.1021\/acs.inorgchem.0c03120"],"URL":"https:\/\/doi.org\/10.1021\/acs.inorgchem.0c03120","relation":{},"ISSN":["0020-1669","1520-510X"],"issn-type":[{"value":"0020-1669","type":"print"},{"value":"1520-510X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,24]]}}}