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This novel ligand is hypothesized to lower the MnII\/III redox potential relative to previously reported derivatives, while retaining the high kinetic inertness and good relaxivity properties characteristic of MnII bispidine complexes. The [MnIIL1(H2O)]- complex exhibits high thermodynamic stability (log KMnIIL1 = 14.2), notable kinetic inertness (dissociation half-life, t1\/2 = 20.4 h at pH 6 in the presence of 50 equiv of ZnII), and high relaxivity (r1 = 3.91 mM\u20131s\u20131 at 60 MHz, 25 \u00b0C, pH 7), highlighting the suitability of the MnII complex as a platform for MRI probe development. Electrochemical studies revealed a significantly lower oxidation potential (E1\/2 = 306 mV vs SCE) compared to other Mn-bispidine chelates, enabling successful synthesis of the oxidized [MnIIIL1] form in methanol. Although the aqueous stability of the +III oxidation state remains limited and highly dependent on water content, these results demonstrate that the incorporation of a phenolate donor effectively tunes the MnII\/III redox properties of the bispidine scaffold.<\/jats:p>","DOI":"10.1021\/acs.inorgchem.6c01966","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:26:51Z","timestamp":1784719611000},"page":"17494-17508","source":"Crossref","is-referenced-by-count":0,"title":["Tuning the\nRedox Sensitivity of MnII\/MnIII-Bispidine MRI\nProbes by the Introduction of a Phenolate\nDonor"],"prefix":"10.1021","volume":"65","author":[{"given":"Anli","family":"Mahamoud","sequence":"first","affiliation":[{"name":"Universite\u0301 de Strasbourg , , CNRS, IPHC UMR 7178 , ,","place":["Strasbourg, France, F-67 087"]},{"name":"Universite\u0301 d\u2019Orle\u0301ans , , Rue Charles Sadron , ,","place":["Orle\u0301ans, France, F-45071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-2959","authenticated-orcid":true,"given":"Zolta\u0301n","family":"Garda","sequence":"additional","affiliation":[{"name":"Universite\u0301 d\u2019Orle\u0301ans , , Rue Charles Sadron , ,","place":["Orle\u0301ans, France, F-45071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bouvet","sequence":"additional","affiliation":[{"name":"PSL University, Sorbonne Universite\u0301, CNRS , , ,","place":["Paris, France, F-75005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daouda","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Universite\u0301 d\u2019Orle\u0301ans , , Rue Charles Sadron , ,","place":["Orle\u0301ans, France, F-45071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0255-1650","authenticated-orcid":true,"given":"Clotilde","family":"Policar","sequence":"additional","affiliation":[{"name":"PSL University, Sorbonne Universite\u0301, CNRS , , ,","place":["Paris, France, F-75005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-7533","authenticated-orcid":true,"given":"Mourad","family":"Elhabiri","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Strasbourg\/CNRS\/UHA , , 25 Rue Becquerel , ,","place":["Strasbourg, France, F-67087"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-6752","authenticated-orcid":true,"given":"E\u0301va","family":"To\u0301th","sequence":"additional","affiliation":[{"name":"Universite\u0301 d\u2019Orle\u0301ans , , Rue Charles Sadron , ,","place":["Orle\u0301ans, France, F-45071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-5039","authenticated-orcid":true,"given":"Aline M.","family":"Nonat","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Strasbourg , , CNRS, IPHC UMR 7178 , ,","place":["Strasbourg, France, F-67 087"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"issue":"1","key":"2026080308075928700_cit1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00441-004-0976-5","article-title":"Redox Imbalance","volume":"318","author":"Berg","year":"2004","journal-title":"Cell Tissue Res."},{"issue":"5","key":"2026080308075928700_cit2","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive Oxygen Species\n(ROS) Homeostasis\nand Redox Regulation in Cellular Signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. 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