{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:48:31Z","timestamp":1787971711666,"version":"build-2784847793"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"45","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2020B020226008"],"award-info":[{"award-number":["2020B020226008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic nonbacterial prostatitis (CNP) is a common male disease with high incidence and low cure rate. This study aims to investigate the anti-CNP potential of Poria cocos polysaccharides (PPs) in a \u03bb-carrageenan-induced CNP rat model. Results showed that PPs exerted anti-CNP functions by reducing the prostate weight and prostate index as well as the level of C-reactive protein (CRP) and pro-inflammatory cytokines (TNF-\u03b1 and IL-1\u03b2). Further analysis on sex hormones revealed that PPs could favor CNP alleviation by regulating the production of testosterone (T), dihydrotestosterone (DTH), and estradiol (E2). PPs could also alleviate CNP by regulating the level of inducible nitric oxide synthase (iNOS), malonaldehyde (MDA), and superoxide diamutase (SOD) in inflamed prostate, thereby enhancing the anti-oxidative stress activity. As most non-digestive polysaccharides are fermented by gut microbiota rather than being digested directly by the host, we further analyzed PP-induced changes in gut microbiota. Microbiomic analysis revealed that PPs significantly change the profile of gut microbiota. Moreover, the relative abundance of five genera was recovered by PPs with a dose\u2013effect relationship, thereby being suggested to play critical roles in the alleviation of CNP. Epigenomic (methylomic) analysis showed that PPs remodeled the DNA methylome of intestinal epithelia, by which PPs might modify hormone production. In the present study, we reported the anti-CNP activity of PPs as well as the involved mechanisms.<\/jats:p>","DOI":"10.1021\/acs.jafc.0c05943","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T15:49:45Z","timestamp":1603986585000},"page":"12661-12670","source":"Crossref","is-referenced-by-count":44,"title":["<i>Poria cocos<\/i>\n                    Polysaccharides Alleviates\nChronic Nonbacterial Prostatitis by Preventing Oxidative Stress, Regulating\nHormone Production, Modifying Gut Microbiota, and Remodeling the DNA\nMethylome"],"prefix":"10.1021","volume":"68","author":[{"given":"Junsheng","family":"Liu","sequence":"first","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntong","family":"Yu","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-5203","authenticated-orcid":true,"given":"Xichun","family":"Peng","sequence":"additional","affiliation":[{"name":"Jinan University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"2026081505065571100_cit1","volume-title":"Pathogenesis and treatment\nof urinary tract infections","author":"Stamey","year":"1980"},{"key":"2026081505065571100_cit2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00345-003-0336-1","article-title":"Chronic prostatitis: what we know, what we do not know,\nand what we should do!","volume":"21","author":"Lobel","year":"2003","journal-title":"World J. 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