{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:55:45Z","timestamp":1784649345385,"version":"3.55.0"},"reference-count":106,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["107-2320-B-003-007"],"award-info":[{"award-number":["107-2320-B-003-007"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["108-2320-B-003-002"],"award-info":[{"award-number":["108-2320-B-003-002"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["109-2320-B-003-009"],"award-info":[{"award-number":["109-2320-B-003-009"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2021,3,3]]},"DOI":"10.1021\/acs.jafc.0c07327","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T19:43:20Z","timestamp":1614023000000},"page":"2422-2437","source":"Crossref","is-referenced-by-count":75,"title":["Prebiotic Lactulose Ameliorates the Cognitive Deficit in Alzheimer\u2019s Disease Mouse Model through Macroautophagy and Chaperone-Mediated Autophagy Pathways"],"prefix":"10.1021","volume":"69","author":[{"given":"Yan-Suan","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar-Ming","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hei-Jen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Mackay Junior College of Medicine, Nursing and Management, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-9917","authenticated-orcid":true,"given":"Guey-Jen","family":"Lee-Chen","sequence":"additional","affiliation":[{"name":"Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hwa","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-0714","authenticated-orcid":true,"given":"Hsiu Mei","family":"Hsieh-Li","sequence":"additional","affiliation":[{"name":"Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Chiun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10093793"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00177"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.8b08046"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.094"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nm985"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.10.005"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2014.07.006"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040348"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2019.09.009"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(97)00455-1"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2015.03.009"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2005.02.013"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601829"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.11.011"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02359-07"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2019.02.003"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2014.887055"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b02305"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jf503484d"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.08.008"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70372"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1530-4"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.2174\/1871527314666150821101522"},{"issue":"5","key":"ref25\/cit25","volume":"9","author":"Chen C. M.","year":"2020","journal-title":"Cells"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170322"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12108"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12068"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100309"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/cells7120278"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091865"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.11.034"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.4161\/auto.19496"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.21.5720"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200507002"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702824200"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0001-6"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.2799391"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5274.501"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)61529-2"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14587"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12734"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103074"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.12.035"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13029"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X19500757"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2739"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201900195"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2015.00312"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-2778-8"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05602-z"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.03.004"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-020-01521-y"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00075"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01008"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00226"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106931"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05016-4"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012537"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351219"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl280"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3348-05.2005"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00347.x"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-48"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00735"},{"issue":"1","key":"ref67\/cit67","first-page":"18","volume":"104","author":"Persson E.","year":"1991","journal-title":"Jordemodern"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27838"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.11.1625"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1981.241.5.G397"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37582-8"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512005727"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO00236D"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b01809"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1987.11739775"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0733-2"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4948"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.10.007"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20967"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1021\/jf500678p"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00802"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-1546-x"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2010.10.001"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.022"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.3390\/cells7050037"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1039\/b804606a"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609532200"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8933-0"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507436103"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1101\/gad.220897.113"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170057"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.4161\/auto.4144"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1007\/BF01534924"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1038\/srep43153"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070472"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002906"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.3920\/BM2020.0100"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.612"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2010.09.026"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208313"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-306928"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510000176"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2015.9"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.08.018"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1038\/nature25178"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.0c07327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T21:13:39Z","timestamp":1682630019000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.0c07327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":106,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,3,3]]}},"alternative-id":["10.1021\/acs.jafc.0c07327"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.0c07327","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]}}}