{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T09:45:12Z","timestamp":1784454312315,"version":"3.55.0"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2020-04-23"],"award-info":[{"award-number":["320.6750.2020-04-23"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873209"],"award-info":[{"award-number":["81873209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903821"],"award-info":[{"award-number":["81903821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973718"],"award-info":[{"award-number":["81973718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004012"],"award-info":[{"award-number":["82004012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1801284"],"award-info":[{"award-number":["U1801284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["11620448"],"award-info":[{"award-number":["11620448"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Program of Guangzhou","award":["201903010062"],"award-info":[{"award-number":["201903010062"]}]},{"name":"Science and Technology Program of Guangzhou","award":["907158833068"],"award-info":[{"award-number":["907158833068"]}]},{"name":"the Guangdong Science and Technology Foundation","award":["2017A030306004"],"award-info":[{"award-number":["2017A030306004"]}]},{"name":"the Guangdong Science and Technology Foundation","award":["2019A1515010909"],"award-info":[{"award-number":["2019A1515010909"]}]},{"name":"the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program","award":["2017BT01Y036"],"award-info":[{"award-number":["2017BT01Y036"]}]},{"name":"Project of Administration of Traditional Chinese Medicine of Guangdong Province of China","award":["20182022"],"award-info":[{"award-number":["20182022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2021,6,30]]},"DOI":"10.1021\/acs.jafc.1c01514","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T20:24:10Z","timestamp":1622579050000},"page":"7016-7027","source":"Crossref","is-referenced-by-count":28,"title":["Theacrine, a Potent Antidepressant Purine Alkaloid from a Special Chinese Tea, Promotes Adult Hippocampal Neurogenesis in Stressed Mice"],"prefix":"10.1021","volume":"69","author":[{"given":"Shu-Hua","family":"Ouyang","sequence":"first","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China"},{"name":"Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jia","family":"Zhai","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Department of Pharmacy, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China"},{"name":"Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Xie","sequence":"additional","affiliation":[{"name":"Zhongshan Institute, University of Electronic Science and Technology of China, Zhongshan 528402, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-En","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Fu","family":"Mao","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hua","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Hua","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jun","family":"Duan","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-5672","authenticated-orcid":true,"given":"Rong-Rong","family":"He","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China"},{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00653-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1177\/0004867414567759"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-005-0148-2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201100894"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283564dd9"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(92)90012-B"},{"key":"ref8\/cit8","first-page":"83","volume":"51","author":"Fredholm B. B.","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000120965.63962.93"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300232"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00007-5"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15324-7"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00086-9"},{"key":"ref14\/cit14","first-page":"1160","volume":"25","author":"Xie G.","year":"2009","journal-title":"Chin. Pharmacol. Bull."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/10286020601103155"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.05.003"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153281"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2016.1178678"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nature07455"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.12.013"},{"key":"ref22\/cit22","first-page":"401","volume":"299","author":"Duman R. S.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018812"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.04.011"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jf400982c"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.08.017"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01568.2000"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.02.022"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00203-6"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/srep05632"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.09.018"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/srep06613"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.05.056"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1588-x"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706766"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1610-5"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.03.035"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.01.026"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(91)90454-2"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.112613"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.09.033"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112318"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3855"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061361"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.70108"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1625-5"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.04.014"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000146RR"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083328"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3168"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.008"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.06.023"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0357"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.85"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.07.021"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-09-03642.1992"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903130308"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20155"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3109\/10253890009001124"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.08.001"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01096"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.08.036"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.596823"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.1c01514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T09:40:52Z","timestamp":1682415652000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.1c01514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":65,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2021,6,30]]}},"alternative-id":["10.1021\/acs.jafc.1c01514"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.1c01514","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}