{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:30:59Z","timestamp":1793809859995,"version":"4.6.1"},"reference-count":226,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["58-6060-6-015"],"award-info":[{"award-number":["58-6060-6-015"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2021,8,4]]},"DOI":"10.1021\/acs.jafc.1c02616","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T17:31:47Z","timestamp":1626888707000},"page":"8324-8346","source":"Crossref","is-referenced-by-count":133,"title":["Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery"],"prefix":"10.1021","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-7594","authenticated-orcid":true,"given":"Thomas C.","family":"Sparks","sequence":"first","affiliation":[{"name":"Agrilucent LLC, Greenfield, Indiana 46140, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-5168","authenticated-orcid":true,"given":"Stephen O.","family":"Duke","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"ref1\/cit1","unstructured":"Agrochemicals\nfrom Natural Products\n                      ; Godfrey, C. R. A., Ed. Marcel Dekker: New York, 1995; p 418."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/np300024u"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3744"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4458"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"ref6\/cit6","unstructured":"Metcalf, R. L.\n                      Organic Insecticides: Their Chemistry and Mode of Action\n                      ; Interscience Publishers: New York, 1955; p 392."},{"key":"ref7\/cit7","unstructured":"Hartly, G. S.; West, T. F.\n                      Chemical for Pest Control\n                      ; Pergamon Press: New York, 1969; p 316."},{"key":"ref8\/cit8","first-page":"215","volume-title":"Agrochemical from Natural Products","author":"Kornis G. I.","year":"1995"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/1526-4998(200008)56:8<696::AID-PS182>3.0.CO;2-5"},{"key":"ref10\/cit10","first-page":"1478","volume-title":"Modern Crop Protection Compounds","volume":"3","author":"Pitterna T.","year":"2019","edition":"3"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-008-9205-8"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-019-0193-9"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1021\/bk-2019-1334.ch002","volume-title":"Safe and Sustainable Crop Protection","author":"Meyer K. G.","year":"2019"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00504"},{"key":"ref15\/cit15","first-page":"3","volume-title":"Pyrethrum, The Natural Insecticide","author":"McLaughlin G. A.","year":"1973"},{"key":"ref16\/cit16","first-page":"63","volume-title":"Agrochemicals from Natural Products","author":"Henrick C. A.","year":"1995"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja01177a065"},{"key":"ref18\/cit18","first-page":"163","volume-title":"The Future for Insecticides: Needs and Prospects","author":"Elliott M.","year":"1976"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780270403"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/246169a0"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/00021369.1974.10861252"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2019.09.002"},{"key":"ref23\/cit23","unstructured":"Wood, A. Index of New ISO Common Names, Compendium of Pesticide Common Names, 2021. http:\/\/www.alanwood.net\/pesticides\/index_new_frame.html (accessed 2021-03-24)."},{"key":"ref24\/cit24","unstructured":"Kuhr, R. J.; Dorough, H. W.\n                      Carbamte Insecticides: Chemistry, Biochemistry and Toxicology\n                      ; CRC Press: Cleveland, OH, 1976; p 301."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jf60037a003"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/53.5.828"},{"issue":"1","key":"ref27\/cit27","first-page":"139","volume":"30","author":"Gahan J. B.","year":"1964","journal-title":"Bull. W.H.O."},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jf60146a007"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","unstructured":"Sl\u00e1ma, K.; Roma\u0148uk, M. \u0160orm, F.\n                      Insect Hormones and Bioanalogues\n                      ; Springer-Verlag:New York, 1974; p 477.","DOI":"10.1007\/978-3-7091-8331-1"},{"key":"ref30\/cit30","first-page":"103","volume-title":"Safer Insecticides: Development and Use","author":"Sparks T. C.","year":"1990"},{"key":"ref31\/cit31","first-page":"121","volume-title":"Insect Control: Biological and Synthetic Agents","author":"Dhadialla T. S.","year":"2010"},{"key":"ref32\/cit32","first-page":"147","volume-title":"Agrochemicals from Natural Products","author":"Henrick C. A.","year":"1995"},{"key":"ref33\/cit33","first-page":"1049","volume-title":"Modern Crop Protection Compounds","volume":"3","author":"Hatakoshi M.","year":"2019","edition":"3"},{"key":"ref34\/cit34","unstructured":"Agranova Alliance. Crop Protection\nActives. http:\/\/www.agranova.co.uk (accessed 2021-03-21)."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1021\/bk-1993-0524.ch015","volume-title":"Pest Control with Enhanced Environmental Safety","author":"Kuhn D. G.","year":"1993"},{"key":"ref36\/cit36","first-page":"1149","volume-title":"Modern Crop Protection Compounds","volume":"3","author":"Kuhn D.","year":"2019","edition":"3"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/bk-1992-0504.ch025","volume-title":"Synthesis and Chemistry of Agrochemicals III","author":"Addor R. W.","year":"1992"},{"key":"ref38\/cit38","first-page":"311","volume-title":"Agrochemicals from Natural Products","author":"Godfrey C. R. A.","year":"1995"},{"key":"ref39\/cit39","first-page":"634","volume-title":"Modern Crop Protection Compounds","volume":"2","author":"Gewehr M.","year":"2019","edition":"3"},{"key":"ref40\/cit40","first-page":"1156","volume-title":"Modern Crop Protection Compounds","volume":"3","author":"Sparks T. C.","year":"2019","edition":"3"},{"key":"ref41\/cit41","first-page":"371","volume-title":"Synthesis and Chemistry of Agrochemicals III","author":"Clough J. M.","year":"1992"},{"key":"ref42\/cit42","first-page":"1","volume-title":"Agrochemicals from Natural Products","author":"Addor R. W.","year":"1995"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/9783527699261","volume-title":"Modern Crop Protection Compounds","volume":"3","author":"Jeschke P.","year":"2019","edition":"3"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201302550"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3932"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2014.10.011"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2014.11.014"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2020.104587"},{"key":"ref49\/cit49","first-page":"1","volume-title":"Recent Highlights in the Discovery and Optimization of Crop Protection Products","author":"Maienfisch P.","year":"2021"},{"key":"ref50\/cit50","first-page":"145","volume":"3","author":"Lind R. J.","year":"2002","journal-title":"British Crop Protection Conference - Pests & Diseases 2002"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2017.810"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-4-431-67933-2_2","volume-title":"Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor","author":"Ujv\u00e1ry I.","year":"1999"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780440121"},{"key":"ref54\/cit54","first-page":"188","volume":"102","author":"Ujv\u00e1ry I.","year":"1996","journal-title":"Magyar K\u00e9miai Foly\u00f3irat"},{"key":"ref55\/cit55","first-page":"199","volume-title":"Synthesis and Chemistry of Agrochemicals VI","author":"Lyga J. W.","year":"2002"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/jo00272a012"},{"key":"ref57\/cit57","first-page":"211","volume-title":"Synthesis and Chemistry of Agrochemicals VI","author":"Henrie II R. N.","year":"2002"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/ps.598"},{"key":"ref59\/cit59","first-page":"273","volume-title":"Comprehensive Insect Physiology, Biochemistry and Pharmacology","volume":"12","author":"Su H. C. F.","year":"1985"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/1526-4998(200008)56:8<651::AID-PS201>3.0.CO;2-U"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780260211"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1021\/bk-1989-0387.ch013","volume-title":"Insecticides of Plant Origin","author":"Miyakado M.","year":"1989"},{"key":"ref63\/cit63","first-page":"151","volume-title":"Recent Advances in the Chemistry of Insect Control II","author":"Blade R. J.","year":"1990"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1584\/jpestics.10.25"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103464"},{"key":"ref66\/cit66","first-page":"52","volume-title":"Recent Advances in the Chemistry of Insect Control II","author":"Fisher M. H.","year":"1990"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)74312-7"},{"key":"ref68\/cit68","first-page":"171","volume-title":"Biopesticides: Use and Delivery","author":"Sparks T. C.","year":"1999"},{"key":"ref69\/cit69","first-page":"207","volume-title":"Insect Control: Biological and Synthetic Agents","author":"Salgado V. L.","year":"2010"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6073"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22894-6"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5217"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/272734a0"},{"key":"ref74\/cit74","first-page":"114","volume-title":"Recent Advances in the Chemistry of Insect Control","author":"Holan G.","year":"1985"},{"key":"ref75\/cit75","unstructured":"Eto, M.\n                      Organophosphorus Pesticides: Organic and Biological Chemistry\n                      ; CRC Press: Cleveland, OH, 1974; p 387."},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1007\/BF01945541"},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1021\/bk-1988-0380.ch020","volume-title":"Biologically Active Natural Products","author":"Cardellina J. H.","year":"1988"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1021\/jo00054a013"},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-4-431-67933-2_3","volume-title":"Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor","author":"Kollmeyer W. D.","year":"1999"},{"key":"ref80\/cit80","first-page":"49","volume-title":"Eighth International Congress of Pesticide Chemistry: Options 2000","author":"Shiokawa K.","year":"1995"},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-4-431-67933-2_4","volume-title":"Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor","author":"Kagabu S.","year":"1999"},{"key":"ref82\/cit82","unstructured":"O\u2019Brien, R. D.\n                      Insecticides, Action and Metabolism\n                      ; Academic Press: New York, 1967; p 332."},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/ja00035a048"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6293"},{"key":"ref85\/cit85","first-page":"291","volume-title":"Comprehensive Insect Physiology, Biochemistry and Pharmacology","volume":"12","author":"Fukami J.-I.","year":"1985"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1002\/qsar.19960150403"},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1021\/bk-1991-0443.ch038","volume-title":"Synthesis and Chemistry of Agrochemicals II","author":"Hsu A.C.-T.","year":"1991"},{"key":"ref88\/cit88","first-page":"1013","volume-title":"Modern Crop Protection Compounds","volume":"3","author":"Dhadialla T. S.","year":"2019","edition":"3"},{"key":"ref89\/cit89","unstructured":"Brooks, G. T.\n                      Chlorinated Insecticides\n                      ; CRC Press: Cleveland, OH, 1974; Vol. 1, p 249."},{"key":"ref90\/cit90","first-page":"1449","volume-title":"Modern Crop Protection Compounds","volume":"3","author":"Salgado V. L.","year":"2019","edition":"3"},{"key":"ref91\/cit91","first-page":"29","volume-title":"Insect Pharmacology: Channels, Receptors, Toxins and Enzymes","author":"Buckingham S. D.","year":"2010"},{"key":"ref92\/cit92","first-page":"85","volume-title":"Advances in the Chemistry of Insect Control III","author":"Kristinsson H.","year":"1994"},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/9783527699261.ch34","volume-title":"Modern Crop Protection Compounds","volume":"3","author":"Maienfisch P.","year":"2019","edition":"3"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.04.001"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2017.03.005"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1584\/jpestics.D16-104"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.155"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.761457"},{"key":"ref99\/cit99","unstructured":"Yu, S. J.\n                      The Toxicology and Biochemistry of Insecticides\n                      , 2nd ed. CRC Press: Boca Raton, FL, 2015; p 358."},{"issue":"2","key":"ref100\/cit100","first-page":"244","volume":"33","author":"Wheaton T. A.","year":"1970","journal-title":"Lloydia"},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/B978-0-12-821035-2.00016-4","volume-title":"Recent Highlights in the Discovery and Optimization of Crop Protection Products","author":"Dickhaut J.","year":"2021"},{"key":"ref102\/cit102","unstructured":"Fungicide\nResistance Action\nCommittee (FRAC). http:\/\/www.frac.info\/ (accessed\n2021-03-25)."},{"key":"ref103\/cit103","unstructured":"Herbicide Resistance Action\nCommittee (HRAC). http:\/\/www.hracglobal.com\/ (accessed 2021-03-25)."},{"key":"ref104\/cit104","unstructured":"Insecticide Resistance Action\nCommittee. http:\/\/www.irac-online.org (accessed 2021-03-25)."},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6254"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1614\/0043-1745(2001)049[0290:ITBTMD]2.0.CO;2"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1934.228.1-2.90"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1934.228.1-2.104"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1038\/135101a0"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1002\/j.1537-2197.1939.tb09296.x"},{"key":"ref111\/cit111","first-page":"87","volume":"7","author":"Hitchcock A. E.","year":"1935","journal-title":"Contrib. Boyce Thompson Inst."},{"key":"ref112\/cit112","first-page":"209","volume":"7","author":"Zimmerman P. W.","year":"1935","journal-title":"Contrib. Boyce Thompson Inst."},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1021\/ja01851a601"},{"key":"ref114\/cit114","first-page":"321","volume":"12","author":"Zimmerman P. W.","year":"1942","journal-title":"Contrib. Boyce Thompson Inst."},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1086\/335289"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1126\/science.100.2590.154"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1038\/155497a0"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1017\/S0043174500093218"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9063(199812)54:4<377::AID-PS827>3.0.CO;2-0"},{"key":"ref120\/cit120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-94-011-4173-4_7","volume-title":"Allelopathy in Ecological Agriculture and Forestry","author":"Knudson C. G.","year":"2000"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.03.015"},{"key":"ref122\/cit122","first-page":"785","volume-title":"Encyclopedia of Agrochemicals","volume":"2","author":"Little J. P.","year":"2003"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2007.01.026"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01907-4"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1564\/21aug02"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1016\/0038-0717(80)90024-3"},{"key":"ref127\/cit127","unstructured":"United\nStates Geological Survey. Pesticide\nNational Synthesis Project. https:\/\/water.usgs.gov\/nawqa\/pnsp\/usage\/maps\/index.php (accessed\n2021-01-18)."},{"key":"ref128\/cit128","first-page":"399","volume-title":"Herbicides, Chemistry Degradation, and Mode of Action","author":"Foy C. L.","year":"1975"},{"key":"ref129\/cit129","volume-title":"Physiology of Herbicide Action","author":"Devine M. D.","year":"1993"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1007\/BF00987606"},{"key":"ref131\/cit131","first-page":"153","volume":"1","author":"Gr\u00fcmmer G.","year":"1960","journal-title":"Symp. Br. Ecol. Soc."},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1042\/bj0480422"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19520710103"},{"key":"ref134\/cit134","first-page":"541","volume-title":"Herbicides","volume":"2","author":"Frear D. S.","year":"1976","edition":"2"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780120312"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1038\/207655a0"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.2174\/221031550402141009100114"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.08.053"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00575"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.1021\/np990590i"},{"key":"ref141\/cit141","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2003.12.014"},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1086\/335374"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.1126\/science.114.2967.493-a"},{"key":"ref144\/cit144","first-page":"209","volume-title":"Herbicides","volume":"1","author":"Geissb\u00fchler H.","year":"1975","edition":"2"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.21.8189"},{"key":"ref146\/cit146","first-page":"265","volume":"3","author":"May J. W.","year":"1985","journal-title":"Proc. Br. Crop Protect. Conf."},{"key":"ref147\/cit147","unstructured":"Payne, G. B.; Powell, J. E. ((3,4,5,6-Tetrahydro-2\n                      H\n                      -pyran-2-yl)methoxy)oxabicycloalkane Herbicides. U. S. Patent 4,525,203, 1985."},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1126\/science.143.3605.471"},{"key":"ref149\/cit149","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005414216848"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1021\/jf101827v"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2018.04.006"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2319"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.1017\/wsc.2020.87"},{"key":"ref154\/cit154","unstructured":"Tischler, N.; Palmyra, N. J.; Bell, E. P. Plant Growth Regulation. U.S. Patent 2,576,080, 1951."},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1007\/BF01989424"},{"key":"ref156\/cit156","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-6757(96)90158-8"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19230420504"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1021\/jf00077a045"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80889-3"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.11867"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90109-A"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1021\/jm900610k"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2011.10.007"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(91)83611-N"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.118372"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.2307\/3760381"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200300081"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2019.01.018"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1002\/ps.520"},{"key":"ref170\/cit170","first-page":"767","volume-title":"Modern Crop Protection Compounds","volume":"2","author":"Knauf-Beiter G.","year":"2019","edition":"3"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.1226"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4588"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5511"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1039\/D0GC02063J"},{"key":"ref175\/cit175","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1021\/bk-2007-0948.ch008","volume-title":"Synthesis and Chemistry of Agrochemical VII","author":"Crowley P. J.","year":"2007"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-010-9168-y"},{"key":"ref177\/cit177","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/9783527699261.ch14","volume-title":"Modern Crop Protection Compounds","volume":"2","author":"Hermann D.","year":"2019","edition":"3"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-007-0552-5"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2016.09.056"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1021\/jf049379p"},{"key":"ref181\/cit181","first-page":"727","volume-title":"Modern Crop Protection Compounds","volume":"2","author":"Walter H.","year":"2019","edition":"3"},{"key":"ref182\/cit182","first-page":"70","volume-title":"Advances in the Chemistry of Insect Control III","author":"Hackler R. E.","year":"1994"},{"key":"ref183\/cit183","unstructured":"Dell, S.; Holding, M. J.; Perrior, T. R. The Design and Synthesis of Simple Putative Analogs of Insecticidal Alkaloids. In\n                      Pesticide Chemistry: Advances in International Research, Development, and Legislation: Proceedings of the Seventh International Congress of Pesticide Chemistry (IUPAC) Hamburg 1990\n                      ; VCH Publishers: 1990; Vol. 1, Abst. 01B-05, p 97."},{"key":"ref184\/cit184","first-page":"37","volume-title":"Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control","volume":"1","author":"Soderlund D. M.","year":"2017"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.1021\/tx500520w"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9063(199709)51:1<33::AID-PS605>3.0.CO;2-Z"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.1186\/s13765-019-0471-z"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.1021\/ja971664k"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(95)00138-X"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1021\/jm801334v"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbaa061"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1021\/bi992943i"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6166"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.1038\/srep06190"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.44.293"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.1006\/pest.1995.1061"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1104\/pp.110.3.753"},{"key":"ref198\/cit198","doi-asserted-by":"publisher","DOI":"10.1006\/pest.1996.0050"},{"key":"ref199\/cit199","unstructured":"Harrington, P. M.; Jung, M. E. Process for the Preparation of (+)-Hydantocidin and Herbicidal Analogs Thereof. U.S. Patent5,354,868A, 1994."},{"key":"ref200\/cit200","unstructured":"Lee, S.F.; Anderson, R. J. Preparation of Herbicidal Ribofuranose Derivatives. U.S. Patent5683963A 1997."},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4652"},{"key":"ref202\/cit202","unstructured":"Schueler, G.; Boland, W.; Lauchli, R. Preparation of 6-Substituted Indanoyl Amino Acid Conjugates as Mimics to the Biological Activity of Coronatine. WO Patent 2002055480A2, 2002."},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03443-1"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1002\/ps.1579"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ern344"},{"key":"ref206\/cit206","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/9783527644179.ch7","volume-title":"Modern Crop Protection Compounds","volume":"1","author":"Dietrich H.","year":"2012","edition":"2"},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.1071\/CH10006"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.1021\/ja00846a041"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.1982.tb04531.x"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1017\/S0890037X00032413"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(72)90273-3"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2245"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.1981.tb02725.x"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1986.tb03298.x"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1021\/jf00076a003"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.1021\/bi960955n"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9063(199801)52:1<81::AID-PS666>3.0.CO;2-H"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780390414"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1002\/psc.393"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.1104\/pp.114.239061"},{"key":"ref221\/cit221","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erp082"},{"key":"ref222\/cit222","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1021\/bk-1997-0658.ch019","volume-title":"Phytochemicals for Pest Control","author":"B\u00f6hlendorf B.","year":"1997"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1039\/C9NP00008A"},{"key":"ref224\/cit224","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.05.004"},{"key":"ref225\/cit225","doi-asserted-by":"publisher","DOI":"10.1021\/ja505861d"},{"key":"ref226\/cit226","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201505863"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.1c02616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T23:22:58Z","timestamp":1682637778000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.1c02616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":226,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2021,8,4]]}},"alternative-id":["10.1021\/acs.jafc.1c02616"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.1c02616","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,21]]}}}