{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:41:15Z","timestamp":1787499675245,"version":"build-2736575974"},"reference-count":130,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["ZY2019013"],"award-info":[{"award-number":["ZY2019013"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41876197"],"award-info":[{"award-number":["41876197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872952"],"award-info":[{"award-number":["81872952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2023,2,1]]},"DOI":"10.1021\/acs.jafc.2c06578","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T13:36:00Z","timestamp":1674480960000},"page":"1771-1787","source":"Crossref","is-referenced-by-count":26,"title":["Bioactive Compounds from Brown Algae Alleviate Nonalcoholic Fatty Liver Disease: An Extensive Review"],"prefix":"10.1021","volume":"71","author":[{"given":"Yu","family":"Wu","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-3458","authenticated-orcid":true,"given":"Haibin","family":"Tong","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30039-1"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-313884"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.41"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30011-5"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105484"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107963"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13650"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S230749"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1055\/a-1273-3159"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14655"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz231"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103085"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-018-0879-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2016.08.016"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00523-4"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp158"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00639-3"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.015"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3855"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003100"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33041-7"},{"key":"ref29\/cit29","unstructured":"U.S.\nFood and Drug Administration. Due to\nRisk of Serious Liver Injury, FDA Restricts Use of Ocaliva in Primary\nBiliary Cholangitis Patients with Advanced Cirrhosis.\n                      FDA Drug Safety Communication\n                      , (accessed May 25, 2021). https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/due-risk-serious-liver-injury-fda-restricts-use-ocaliva-primary-biliary-cholangitis-pbc-patients."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30094-9"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1503519"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911850"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101072"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1111\/j.0959-9673.2006.00465.x"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00145.2011"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.011"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.04.019"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.04.009"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22904"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjbas.2017.08.002"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/md16100348"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1080\/09670262.2017.1365273"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/md15110360"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.07.082"},{"key":"ref45\/cit45","unstructured":"Centre d\u2019\u00c9tude et de Valorisation des Algues.\n                      Edible algae - regulatory update\n                      . https:\/\/www.ceva-algues.com\/en\/document\/edible-algae-regulatory-update\/ (accessed 2022-09-14)."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwm014"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.12.042"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116131"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2009.10.015"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32833135fe"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.09.066"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.11.002"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c02555"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3390\/md19030148"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i46.10084"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.02.072"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.10.031"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.10.003"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.01.011"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2012.11.002"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.05.015"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.05.070"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.08.002"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1517725"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13409"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.10.188"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/md19120699"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307913"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.12.183"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.252"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115381"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7697031"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1716207"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12840"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.06.003"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01056.x"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00900"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO04012J"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.08.003"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7249"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3390\/md8072038"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3390\/md18030168"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(98)00177-3"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.12692"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.3390\/md13074270"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12441"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2019.3179"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.06.011"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061327"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090365"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.3390\/md17080434"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12093"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.10.091"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.3390\/md13116866"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.04.051"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1021\/jf502830b"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.3390\/md19060318"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b01945"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.3390\/md15040106"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.02.022"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.12.032"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191015638"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b05118"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(92)80290-U"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-012-9602-2"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.3390\/md13042196"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.5.946"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093563"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.32.2.205"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.10.007"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.2131\/jts.34.501"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.3358\/shokueishi.52.183"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451200606X"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.3390\/foods9081113"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158618"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.05.006"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201000215"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.3390\/ph14101004"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.3390\/md14080148"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132384699"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-013-3784-4"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.022"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.04.052"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.05.050"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002480"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.3390\/md20040225"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113509"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.01.059"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103455"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108486"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.2c06578","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.2c06578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T08:40:12Z","timestamp":1682584812000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.2c06578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,23]]},"references-count":130,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2,1]]}},"alternative-id":["10.1021\/acs.jafc.2c06578"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.2c06578","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,23]]}}}