{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:16:16Z","timestamp":1782958576704,"version":"3.54.5"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204612"],"award-info":[{"award-number":["82204612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2024,6,5]]},"DOI":"10.1021\/acs.jafc.3c08490","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T15:21:51Z","timestamp":1710602511000},"page":"12516-12528","source":"Crossref","is-referenced-by-count":28,"title":["Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K\/Akt\/GSK3\u03b2 Signaling Pathway"],"prefix":"10.1021","volume":"72","author":[{"given":"Ya-wei","family":"Lu","sequence":"first","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-ya","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-han","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-qi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-nan","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-tian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-4298","authenticated-orcid":true,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"},{"name":"College of Life Sciences, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, Changchun 130118, China"},{"name":"Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"issue":"7","key":"ref1\/cit1","first-page":"130","volume":"12","author":"Tripathi B. K.","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01241031"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/796840"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2012-121309"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2022.06.003"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115336"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168680"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12925"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.5604\/20831862.1029820"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21787"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6755"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2010.09.014"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-1027com"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01273-18"},{"issue":"9","key":"ref15\/cit15","first-page":"2810","volume":"10","author":"Mahajan U. B.","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.01.022"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180497"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2020030"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.07.037"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.04.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03198-6"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO03308A"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116596"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116294"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113500"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.03.011"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4838-9"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2045834"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22624"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.21-0120"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b20-00604"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.917213"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.07.015"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2020.12.004"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121696"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00450.x"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8632-x"},{"issue":"2","key":"ref38\/cit38","first-page":"237","volume":"25","author":"Numakawa T.","year":"2010","journal-title":"Histol. Histopathol."},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.05.071"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15057667"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-015-0164-2"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.06.013"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108654"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.03.018"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12214"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2021.07.002"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2022.08.003"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2021.09.015"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00045"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.3c08490","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.3c08490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T10:47:26Z","timestamp":1717584446000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.3c08490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,16]]},"references-count":49,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,6,5]]}},"alternative-id":["10.1021\/acs.jafc.3c08490"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.3c08490","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,16]]}}}