{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:30:45Z","timestamp":1789792245901,"version":"4.0.1"},"reference-count":85,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20400"],"award-info":[{"award-number":["U20A20400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jinan Innovation Team Project","award":["202228040"],"award-info":[{"award-number":["202228040"]}]},{"name":"Fundamental Research Funds for the Research Institutes of Heilongjiang Province","award":["CZKYF2021A002"],"award-info":[{"award-number":["CZKYF2021A002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2024,12,18]]},"DOI":"10.1021\/acs.jafc.4c07319","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T19:50:35Z","timestamp":1733255435000},"page":"27923-27938","source":"Crossref","is-referenced-by-count":13,"title":["Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM<sub>2.5<\/sub>-Induced Lung Injury by Inhibiting the TLR4\/NF-\u03baB p65 Pathway and Regulating the Lung and Gut Microbiome"],"prefix":"10.1021","volume":"72","author":[{"given":"Yang","family":"Sun","sequence":"first","affiliation":[{"name":"College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiming","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlei","family":"Han","sequence":"additional","affiliation":[{"name":"College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Sciences, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhai","family":"Huo","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Sciences, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5846-0013","authenticated-orcid":true,"given":"Rina","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Sciences, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3604-1432","authenticated-orcid":true,"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.160808"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118493"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.04.130"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192114019"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.129106"},{"issue":"6","key":"ref6\/cit6","first-page":"2213","volume":"34","author":"Si-Cong L.","year":"2021","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7379146"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-023-00721-z"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116084"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.927384"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.09.029"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115318"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1078593"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107474"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(23)60435-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.06.052"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.02.041"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.07.011"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2003.09.005"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.55"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0584"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.32"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03748.x"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00357"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-02958-9"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.66875"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3444"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126860"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.137432"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153912"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3027708"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO03969E"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2022.09.030"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/nu16111698"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1105272"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.12.077"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.102416"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7784"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122608"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.06.181"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119147"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3486841"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108510"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.08.057"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.02.016"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2023.106635"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.09.086"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-023-01141-4"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3390\/life12122144"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01714-0"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9097"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.09.079"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-024-01772-6"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2022.05.016"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.130758"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.161013"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-023-12457-9"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03953-7"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3390\/plants12071508"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.12.044"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8091347"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-25111-0"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062220"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3390\/foods12081632"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.164050"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.777147"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321173"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153927"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1133167"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.784211"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.004"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-022-01411-z"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2770"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00906"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.142"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00182"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140625"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/nature12726"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.014"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.75"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102829"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1211259"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02380"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.774433"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00945"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.4c07319","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.4c07319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:34:05Z","timestamp":1734514445000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.4c07319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":85,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2024,12,18]]}},"alternative-id":["10.1021\/acs.jafc.4c07319"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.4c07319","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,3]]}}}