{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:05:37Z","timestamp":1792789537868,"version":"4.5.0"},"reference-count":67,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Research Council of Tehran University of Medical Sciences","id":[{"id":"https:\/\/ror.org\/01c4pz451","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this review is to address the most up-to-date information on the design and development, structure\u2013activity relationship (SAR), and molecular docking study of novel and effective urease inhibitors between January 2020 and March 2024. Herein, the importance of the substituents and their effect on bioactivity of the reported compounds have been investigated. Besides, the relation between the most important residues inside the active site of the urease enzyme for interactions of the inhibitors and the active site of the enzyme has also been reviewed. This review has been classified into main reported scaffolds, namely, barbiturates, thiobarbiturates, Schiff bases, semicarbazides, thiosemcarbazides, benzimidazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles, to provide better insight into the newly developed urease inhibitors.<\/jats:p>","DOI":"10.1021\/acs.jafc.4c07972","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T01:33:11Z","timestamp":1739151191000},"page":"3795-3815","source":"Crossref","is-referenced-by-count":25,"title":["The Most Up-to-Date Advancements in the Design and\nDevelopment of Urease Inhibitors (January 2020\u2013March 2024)"],"prefix":"10.1021","volume":"73","author":[{"given":"Danial","family":"Babaei","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences , , ,","place":["Tehran, Iran, 1417614411"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Saeedian Moghadam","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences , , ,","place":["Tehran, Iran, 1417614411"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latifeh","family":"Navidpour","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences , , ,","place":["Tehran, Iran, 1417614411"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-2917","authenticated-orcid":true,"given":"Mohsen","family":"Amini","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences , , ,","place":["Tehran, Iran, 1417614411"]},{"name":"Tehran University of Medical Sciences , , ,","place":["Tehran, Iran, 1417614411"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"2026090713192761700_cit1","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3390\/su16010188","article-title":"Modified Urea\nFertilizers and Their\nEffects on Improving Nitrogen Use Efficiency (NUE)","volume":"16","author":"Swify","year":"2024","journal-title":"Sustainability"},{"key":"2026090713192761700_cit2","doi-asserted-by":"publisher","first-page":"11584","DOI":"10.1021\/acs.jafc.9b04244","article-title":"Soil aggregate\nstratification of ureolytic microbiota affects urease activity in\nan Inceptisol","volume":"67","author":"Wang","year":"2019","journal-title":"J. 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