{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:41:14Z","timestamp":1790221274877,"version":"4.1.0"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"49","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81891011"],"award-info":[{"award-number":["81891011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973472"],"award-info":[{"award-number":["81973472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2024,12,11]]},"DOI":"10.1021\/acs.jafc.4c09227","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T12:34:00Z","timestamp":1732883640000},"page":"27248-27264","source":"Crossref","is-referenced-by-count":7,"title":["Existing Forms of Notoginsenoside R<sub>1<\/sub> in Rats and Their Potential Bioactivities"],"prefix":"10.1021","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5246-1188","authenticated-orcid":true,"given":"Meng-Ge","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"},{"name":"Medical College of Tibet University, Lasa 850002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5904-0160","authenticated-orcid":true,"given":"Lin-Han","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Rong","family":"Bai","sequence":"additional","affiliation":[{"name":"Medical College of Tibet University, Lasa 850002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Meng","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Gao","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yang","family":"Dou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Medical College of Tibet University, Lasa 850002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Medical College of Tibet University, Lasa 850002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Xue","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Qing","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"},{"name":"Medical College of Tibet University, Lasa 850002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China"},{"name":"Medical College of Tibet University, Lasa 850002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref1\/cit1","unstructured":"National\nPharmacopoeia Committee.  Pharmacopoeia of the People\u2019s\nRepublic of China 2020; China Medical Science\nand Technology Press: Beijing, 2020; Vol. 12, p 411."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2011.1801"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2023.105541"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.05.005"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.02.035"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/204840"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhae170"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO04089H"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20200112.101"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/jf502214x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.04.122"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14143"},{"key":"ref13\/cit13","unstructured":"Huang, J. Pure natural health food and processing technology thereof, CN 114,947,044 A, 2022."},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S240511"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jf803320d"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154261"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA01470J"},{"key":"ref18\/cit18","first-page":"688","volume":"16","author":"Xu F.","year":"2014","journal-title":"World Sci. Technol."},{"key":"ref19\/cit19","first-page":"3435","volume":"40","author":"Cai S. Q.","year":"2015","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"2","key":"ref20\/cit20","first-page":"485","volume":"21","author":"Chen G.","year":"2010","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4670"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.09.027"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.09.031"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c01857"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116156"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217267"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120704"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jf405482s"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16011677"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx374"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq300"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00025"},{"key":"ref33\/cit33","volume-title":"Study on the directed hydration catalytic for the PPT-type saponins, activity screening and mechanism concerning derivatives","author":"Liu J.","year":"2022"},{"issue":"10","key":"ref34\/cit34","first-page":"924","volume":"40","author":"Ma S.","year":"2005","journal-title":"Acta Pharm. Sin. B"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b00710"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.12.028"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c01093"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA06029B"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.102734"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-023-04024-6"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172418"},{"issue":"10","key":"ref42\/cit42","first-page":"1478","volume":"35","author":"Zhan H. Q.","year":"2004","journal-title":"Guangdong Med."},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2012.702798"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.04.021"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021789"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-023-02070-w"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13805"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2023.10.010"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153988"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S240511"},{"key":"ref51\/cit51","unstructured":"Kim, J.K.; Kim, S.W.; Kim, H.G.; Ko, S.Y.; Kim, J.Y.; Chang, S.; Baek, D.H.; Lee, B.E.; Ko, S.H.; Choi, Y.  Composition comprising notoginseng radix extract for preventing and treating arthritis as an effective ingredient. WO 2,005,023,281 A1, 2005."},{"key":"ref52\/cit52","unstructured":"Kim, J.K.; Kim, S.W.; Kim, H.G.; Ko, S.Y.; Baek, D.H. Herbal composition containing pleurotus eryngii, Acanthopanacis Cortex and Notoginseng Radix extracts for the treatment of periodontitis. WO 2,017,176,608 A1, 2006."},{"key":"ref53\/cit53","unstructured":"Lee, M. U.; Lee, Y. J.; Lee, D. H. Anti-inflammatory composition containing Sparassis crispa and Panax notoginseng. KR 2,023,104,043 A. 2023."},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.06.014"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-020-01265-8"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.716121"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07818-y"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106537"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153503"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.4c09227","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.4c09227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:27:11Z","timestamp":1733938031000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.4c09227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,29]]},"references-count":59,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2024,12,11]]}},"alternative-id":["10.1021\/acs.jafc.4c09227"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.4c09227","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,29]]}}}