{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:04:25Z","timestamp":1792123465604,"version":"4.4.0"},"reference-count":133,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,3,19]]},"DOI":"10.1021\/acs.jafc.4c12480","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T18:22:16Z","timestamp":1741285336000},"page":"6385-6399","source":"Crossref","is-referenced-by-count":43,"title":["Plant Derived Exosome-Like Nanoparticles and Their Therapeutic Applications in Glucolipid Metabolism Diseases"],"prefix":"10.1021","volume":"73","author":[{"given":"Ruolan","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]},{"name":"Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety)","place":["Beijing, China"]},{"name":"Ministry of Agriculture and Rural Affairs of the P.R. China","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1717-8713","authenticated-orcid":true,"given":"Kunlun","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]},{"name":"Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety)","place":["Beijing, China"]},{"name":"Ministry of Agriculture and Rural Affairs of the P.R. China","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-013118-111902"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246205"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01509-3"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(81)90512-5"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2021.05.006"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257633"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300729"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.64"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3095"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.06.018"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061352"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080811"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13081203"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122722"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.7150\/ntno.70999"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202105385"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12069"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.01.025"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4004"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.864188"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.10.001"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-018-2913-1"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0196"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.01.003"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-014-0243-x"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176275"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.7326\/L19-0667"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i39.14219"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.7602"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3967\/bes2023.106"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.109249"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S272378"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32387"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010191"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2017.08.003"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27066"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2016.01.011"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.07.054"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2019.111918"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0991-5"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106733"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12283"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0817-4"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.190"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.08.009"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c02893"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105366"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.9b00954"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b05614"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5186"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.613197"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-022-00413-9"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.03.026"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00534"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18133"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.7150\/thno.41580"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/srep33641"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2020.07.016"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8545347"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b01636"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1039\/D3MH01030A"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.2023699"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12048"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.116"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.01.060"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01657-6"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00858-8"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jplph.2018.07.006"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114108"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.28713"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207826"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.188"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2886"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2194"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2023.01.004"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.10.032"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121178"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S293067"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.7150\/thno.73650"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO01094E"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S425173"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.3390\/biom11010087"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-017-9026-7"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238184"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02065-0"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301357"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.10.004"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2023.100394"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2023.2195093"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.04.005"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.159"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.07.021"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00921"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.12.023"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00053"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1021\/cr300068p"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.7150\/thno.97096"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.04.023"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030476"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.80"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00928-y"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.04.039"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1852171"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.7150\/thno.62514"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.7150\/thno.52558"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004282107"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.05.015"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.7150\/thno.65427"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61032-X"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02120-w"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202308680"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S478589"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091981"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1038\/srep44612"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03003-w"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.004"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c170012"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00681-w"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154679"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01125-5"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02161-1"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401466"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116855"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02006-x"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2017.10.001"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.4103\/tcmj.tcmj_182_19"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.071"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020477"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01755-5"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.08.016"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.4c12480","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.4c12480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:12:50Z","timestamp":1742371970000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.4c12480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":133,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,3,19]]}},"alternative-id":["10.1021\/acs.jafc.4c12480"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.4c12480","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]}}}