{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:18:40Z","timestamp":1792631920829,"version":"4.5.0"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bananas (Musaceae), herbaceous plants widely cultivated in tropical and subtropical regions, are traditionally used for their purported therapeutic effects on early-stage gastric ulcers. This comprehensive review provides an analysis of the bioactive compounds in bananas, with a focus on the influence of varietal differences and ripening stages. Researchers have identified key bioactive molecules in bananas, including phenolic compounds, carotenoids, and biogenic amines, predominantly located in the banana peel. Unripe bananas contain higher levels of phenolic compounds and biogenic amines, whereas ripened bananas exhibit increased carotenoid content. Additionally, in vivo studies have indicated that flavonoids, particularly leucocyanidin, exert gastroprotective effects by enhancing gastric mucosal thickness and increasing epidermal growth factor receptor expression, which promotes angiogenesis and re-epithelialization of the gastric mucosa, thereby protecting against ulcer formation. The findings reinforce the medicinal value of bananas, particularly in their unripe state, and highlight the importance of further exploration into their bioactive components for the development of natural therapies targeting gastric health.<\/jats:p>","DOI":"10.1021\/acs.jafc.4c12972","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T14:01:21Z","timestamp":1746280881000},"page":"14689-14706","source":"Crossref","is-referenced-by-count":8,"title":["Healing from the\nPeel: Exploring the Bioactive Potential\nof Bananas for Gastric Ulcer Management"],"prefix":"10.1021","volume":"73","author":[{"given":"R. Lizeth P.","family":"Mun\u0303oz","sequence":"first","affiliation":[{"name":"Universidad Icesi , , Calle 18 No. 122\u2212135 , ,","place":["Cali, Colombia, 760031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina P.","family":"Mora","sequence":"additional","affiliation":[{"name":"Universidad Icesi , , Calle 18 No. 122\u2212135 , ,","place":["Cali, Colombia, 760031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura V.","family":"Parra-Perdomo","sequence":"additional","affiliation":[{"name":"Universidad Icesi , , Calle 18 No. 122\u2212135 , ,","place":["Cali, Colombia, 760031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-2892","authenticated-orcid":true,"given":"Giovanni","family":"Rojas","sequence":"additional","affiliation":[{"name":"Universidad Icesi , , Calle 18 No. 122\u2212135 , ,","place":["Cali, Colombia, 760031"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"issue":"3","key":"2026090713195552200_cit1","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3390\/life13030706","article-title":"Plant Metabolomics:\nAn Overview of the Role of Primary and Secondary Metabolites against\nDifferent Environmental Stress Factors","volume":"13","author":"Salam","year":"2023","journal-title":"Life"},{"key":"2026090713195552200_cit2","first-page":"355","article-title":"La Participacio\u0301n de los Metabolitos\nSecundarios en la Defensa de las Plantas","volume":"21","author":"Sepu\u0301lveda-Jime\u0301nez","year":"2003","journal-title":"Rev.\nMex. 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Food Meas.\nCharact."},{"issue":"3","key":"2026090713195552200_cit31","first-page":"1041","article-title":"Total Phenolics,\nFlavonoids and Antioxidant Activity of Banana Pulp and Peel Flours:\nInfluence of Variety and Stage of Ripeness","volume":"19","author":"Fatemeh","year":"2012","journal-title":"Int. Food Res. J."},{"issue":"2","key":"2026090713195552200_cit32","first-page":"749","article-title":"Changes in Antioxidant Properties and Chemical Composition\nduring Ripening in Banana Variety \u2018Hom Thong\u2019 (AAA Group)\nand \u2018Khai\u2019 (AA Group)","volume":"21","author":"Fernando","year":"2014","journal-title":"Int. Food\nRes. J."},{"issue":"4","key":"2026090713195552200_cit33","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1631\/jzus.B1200177","article-title":"Effect of\nPhysiological Harvest Stages on the Composition of Bioactive Compounds\nin Cavendish Bananas","volume":"14","author":"Bruno Bonnet","year":"2013","journal-title":"J. Zhejiang Univ. 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Food Chem."},{"issue":"4","key":"2026090713195552200_cit41","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1177\/156482650602700401","article-title":"Carotenoid Content\nand Flesh Color of Selected Banana Cultivars Growing\nin Australia","volume":"27","author":"Englberger","year":"2006","journal-title":"Food Nutr. Bull."},{"issue":"4","key":"2026090713195552200_cit42","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/pbi.12650","article-title":"Golden Bananas in the\nField: Elevated Fruit Pro-Vitamin A from the Expression of a Single\nBanana Transgene","volume":"15","author":"Paul","year":"2017","journal-title":"Plant Biotechnol. J."},{"issue":"11","key":"2026090713195552200_cit43","first-page":"1833","article-title":"Effects of Light on\nCarotenoid Biosynthesis and Color Formation of Citrus Fruit Peel","volume":"14","author":"Tao","year":"2003","journal-title":"J. Appl. 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