{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:17:19Z","timestamp":1788387439172,"version":"build-2803163510"},"reference-count":21,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T00:00:00Z","timestamp":1481328000000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee, Hong Kong","doi-asserted-by":"publisher","award":["ECS 609913"],"award-info":[{"award-number":["ECS 609913"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005950","name":"Hong Kong University of Science and Technology","doi-asserted-by":"publisher","award":["R9310"],"award-info":[{"award-number":["R9310"]}],"id":[{"id":"10.13039\/501100005950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Emerging evidence has suggested aristolochic acids (AAs) are linked to the development of Balkan endemic nephropathy (BEN), a chronic renal disease affecting numerous farmers living in the Balkan peninsula. However, the pathway by which AAs enter the human food chain and cause kidney disease remains poorly understood. Using our previously developed analytical method with high sensitivity and selectivity (Chan, W.; Lee, K. C.; Liu, N.; Cai, Z. J. Chromatogr. A\u00a02007, 1164, 113\u2013119), we quantified AAs in lettuce, tomato, and spring onion grown in AA-contaminated soil and culture medium. Our study revealed that AAs were being taken up from the soil and bioaccumulated in food crops in a time- and dose-dependent manner. To the best of our knowledge, this study is the first to identify one of the possible pathways by which AAs enter our food chain to cause chronic food poisoning. Results also demonstrated that AAs were resistant to the microbial activity of the soil\/water.<\/jats:p>","DOI":"10.1021\/acs.jafc.5b05089","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T05:23:29Z","timestamp":1449725009000},"page":"107-112","source":"Crossref","is-referenced-by-count":49,"title":["Uptake and Accumulation of Nephrotoxic and Carcinogenic\nAristolochic Acids in Food Crops Grown in\n                    <i>Aristolochia clematitis<\/i>\n                    -Contaminated Soil and Water"],"prefix":"10.1021","volume":"64","author":[{"given":"Weiwei","family":"Li","sequence":"first","affiliation":[{"name":"The Hong Kong University of Science and Technology , , Clear Water Bay, , ,","place":["Kowloon, Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Hu","sequence":"additional","affiliation":[{"name":"The Hong Kong University of Science and Technology , , Clear Water Bay, , ,","place":["Kowloon, Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Chan","sequence":"additional","affiliation":[{"name":"The Hong Kong University of Science and Technology , , Clear Water Bay, , ,","place":["Kowloon, Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"2026090218020853300_cit1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.2307\/3434257","article-title":"The etiology of\nBalkan endemic nephropathy: still more questions than answers","volume":"106","author":"Tatu","year":"1998","journal-title":"Environ. 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A."},{"key":"2026090218020853300_cit5","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1021\/tx3000889","article-title":"Biomonitoring of aristolactam-DNA\nadducts in human tissues using ultra-performance liquid chromatography\/iontrap\nmass spectrometry","volume":"25","author":"Yun","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"2026090218020853300_cit6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10653-012-9477-8","article-title":"Possible health\nimpacts of naturally occurring uptake\nof aristolochic acids by maize and cucumber roots: links to the etiology\nof endemic (Balkan) nephropathy","volume":"35","author":"Pavlovic","year":"2013","journal-title":"Environ. 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Mech. Mutagen."},{"key":"2026090218020853300_cit10","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/ki.2011.428","article-title":"Chinese herbs nephropathy and Balkan endemic nephropathy:\ntoward a single entity, aristolochic acid nephropathy","volume":"81","author":"De Broe","year":"2012","journal-title":"Kidney Int."},{"key":"2026090218020853300_cit11","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1021\/es102907v","article-title":"Pesticide\nuptake in potatoes: model and field experiments","volume":"45","author":"Juraske","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"2026090218020853300_cit12","doi-asserted-by":"publisher","first-page":"5220","DOI":"10.1021\/jf401378u","article-title":"Uptake of di(2-ethylhexyl) phthalate (DEHP) by the plant Benincasa\nhispida and its use for lowering DEHP content of intercropped vgetables","volume":"61","author":"Wu","year":"2013","journal-title":"J. Agric. 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Food\nChem."},{"key":"2026090218020853300_cit16","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1021\/jf404282y","article-title":"Fate and\nuptake of pharmaceuticals in soil\u2013plant\nsystems","volume":"62","author":"Carter","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"2026090218020853300_cit17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.chroma.2007.06.055","article-title":"A sensitivity enhanced\nhigh-performance liquid chromatography fluorescence method for the\ndetection of nephrotoxic and carcinogenic aristolochic acid in herbal\nmedicines","volume":"1164","author":"Chan","year":"2007","journal-title":"J. Chromatogr. 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