{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:30:10Z","timestamp":1791196210291,"version":"4.1.0"},"reference-count":83,"publisher":"American Chemical Society (ACS)","issue":"27","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"the Joint Fund of Zhejiang Provincial Natural Science Foundation of China","award":["LLSSZ25H280001"],"award-info":[{"award-number":["LLSSZ25H280001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,7,9]]},"DOI":"10.1021\/acs.jafc.5c00835","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T13:43:52Z","timestamp":1747662232000},"page":"16890-16905","source":"Crossref","is-referenced-by-count":18,"title":["Flavonoids from Shiliangcha (<i>Chimonanthus salicifolius<\/i>) Alleviate Brain Aging in <scp>d<\/scp>-Galactose-Induced Senescent Mice through Gut Microbiota"],"prefix":"10.1021","volume":"73","author":[{"given":"Siyu","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Fuchun Campus","place":["Hangzhou, P. R. China"]},{"name":"Zhejiang Chinese Medical University","place":["Hangzhou, P. R. China"]},{"name":"Department of Food Science and Engineering","place":["Ningbo, P. R. China"]},{"name":"Ningbo University","place":["Ningbo, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Fuchun Campus","place":["Hangzhou, P. R. China"]},{"name":"Zhejiang Chinese Medical University","place":["Hangzhou, P. R. China"]},{"name":"College of Life and Environmental Sciences","place":["Beijing, P. R. China"]},{"name":"Minzu University of China","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongyu","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Fuchun Campus","place":["Hangzhou, P. R. China"]},{"name":"Zhejiang Chinese Medical University","place":["Hangzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Pan","sequence":"additional","affiliation":[{"name":"Chemical Biology Center","place":["Lishui, P. R. China"]},{"name":"Lishui Institute of Agriculture and Forestry Sciences","place":["Lishui, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Fang","sequence":"additional","affiliation":[{"name":"Chemical Biology Center","place":["Lishui, P. R. China"]},{"name":"Lishui Institute of Agriculture and Forestry Sciences","place":["Lishui, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Chemical Biology Center","place":["Lishui, P. R. China"]},{"name":"Lishui Institute of Agriculture and Forestry Sciences","place":["Lishui, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-3338","authenticated-orcid":true,"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering","place":["Ningbo, P. R. China"]},{"name":"Ningbo University","place":["Ningbo, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-9129","authenticated-orcid":true,"given":"Kejun","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Fuchun Campus","place":["Hangzhou, P. R. China"]},{"name":"Zhejiang Chinese Medical University","place":["Hangzhou, P. R. China"]},{"name":"Chemical Biology Center","place":["Lishui, P. R. China"]},{"name":"Lishui Institute of Agriculture and Forestry Sciences","place":["Lishui, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01579-7"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO04381A"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132698"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1168049"},{"key":"ref5\/cit5","volume-title":"Integrating She Pharmacy Research","author":"Cheng K. J.","year":"2017"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/789263"},{"issue":"10","key":"ref7\/cit7","first-page":"1957","volume":"43","author":"Xu J. B.","year":"2018","journal-title":"China J. Chin. Mater. Med."},{"issue":"16","key":"ref8\/cit8","first-page":"2661","volume":"38","author":"Zhang Y.","year":"2013","journal-title":"China J. Chin. Mater. Med."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3282"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.04.025"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210215123239"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30356-4"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2022.102177"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1126\/sageke.2006.6.re1"},{"issue":"3","key":"ref15\/cit15","first-page":"971","volume":"9","author":"Zhang Q.","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.626691"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111769"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.112029"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2021.12.003"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.373680"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00371"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12206-4"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2024.11.007"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1154641"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06678-11"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.12.016"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c05313"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.030"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1159\/000464244"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107272"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0332-6"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.05.004"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.05.025"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2017.08.011"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108719"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.810483"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.105010"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2024.2435593"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2112095118"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20845"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.01.016"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200306"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.661838"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01588"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00273-y"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241511902"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052358"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.2174\/1389203711314010005"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24101"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9268083"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3138"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13030422"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101994"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.03.015"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.2486"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.18097\/pbmc20236902112"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1159\/000490615"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0525-3"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291022"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skae140"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00631-9"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-020-0115-8"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1132857"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121312"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03032-9"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2022.107656"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112183"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03913.x"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102331"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4028394"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01451-w"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143772"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.08.013"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-00427-4"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01770"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/med.21431"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02898-1"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0157-3"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S271927"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010149"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051387"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2023.113849"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082514"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c00835","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c00835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:09:20Z","timestamp":1752610160000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c00835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":83,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2025,7,9]]}},"alternative-id":["10.1021\/acs.jafc.5c00835"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c00835","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]}}}