{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:08:40Z","timestamp":1788804520317,"version":"build-2803163510"},"reference-count":9,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1700103"],"award-info":[{"award-number":["2021YFD1700103"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["BX20240133"],"award-info":[{"award-number":["BX20240133"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M760857"],"award-info":[{"award-number":["2024M760857"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22207037"],"award-info":[{"award-number":["22207037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctor Project of Hubei Province","award":["2024HBBHCXA004"],"award-info":[{"award-number":["2024HBBHCXA004"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GZB20230198"],"award-info":[{"award-number":["GZB20230198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,5]]},"DOI":"10.1021\/acs.jafc.5c01206","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T14:46:26Z","timestamp":1739889986000},"page":"4977-4979","source":"Crossref","is-referenced-by-count":4,"title":["<scp>l<\/scp>\n                    -Histidinol Dehydrogenase (HDH) Represents\na Potential Molecular Target of Herbicides, Bactericides, and Fungicides"],"prefix":"10.1021","volume":"73","author":[{"given":"Xing-Xing","family":"Shi","sequence":"first","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Yingzheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4847-5797","authenticated-orcid":true,"given":"Zhi-Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei University , , ,","place":["Wuhan, P. R. China, 430061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ye","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-2593","authenticated-orcid":true,"given":"Guang-Fu","family":"Yang","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"issue":"2","key":"2026090713192588700_cit1","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1104\/pp.107.096511","article-title":"Genetic dissection\nof histidine biosynthesis in Arabidopsis","volume":"144","author":"Muralla","year":"2007","journal-title":"Plant\nPhysiol."},{"issue":"24","key":"2026090713192588700_cit2","doi-asserted-by":"publisher","first-page":"15711","DOI":"10.1073\/pnas.232454299","article-title":"The analysis of the intramacrophagic\nvirulome of Brucella suis deciphers the environment encountered by\nthe pathogen inside the macrophage host cell","volume":"99","author":"Ko\u0308hler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"2026090713192588700_cit3","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1128\/AAC.00572-07","article-title":"Targeting of the Brucella\nsuis virulence factor histidinol\ndehydrogenase by histidinol analogues results in inhibition of intramacrophagic\nmultiplication of the pathogen","volume":"51","author":"Joseph","year":"2007","journal-title":"Antimicrob.\nAgents Chemother."},{"issue":"21","key":"2026090713192588700_cit4","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.2174\/1568026616666160413140000","article-title":"L-Histidinol\nDehydrogenase as a New Target for Old Diseases","volume":"16","author":"M. Monti","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"issue":"4","key":"2026090713192588700_cit5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/21505594.2016.1146848","article-title":"Histidine biosynthesis\nplays a crucial role in metal homeostasis and virulence of Aspergillus\nfumigatus","volume":"7","author":"Dietl","year":"2016","journal-title":"Virulence"},{"issue":"1","key":"2026090713192588700_cit6","doi-asserted-by":"publisher","first-page":"10476","DOI":"10.1038\/s41598-017-10859-0","article-title":"Structures of Medicago\ntruncatula L-Histidinol Dehydrogenase\nShow Rearrangements Required for NAD+ Binding and the Cofactor\nPositioned to Accept a Hydride","volume":"7","author":"Ruszkowski","year":"2017","journal-title":"Sci. Rep."},{"key":"2026090713192588700_cit7","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jinorgbio.2011.10.019","article-title":"Zinc metalloenzymes as new targets\nagainst the bacterial pathogen Brucella","volume":"111","author":"Lopez","year":"2012","journal-title":"J.\nInorg. Biochem."},{"key":"2026090713192588700_cit8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/B978-0-12-823974-2.00020-6","article-title":"Histidinol dehydrogenase","volume-title":"Metalloenzymes","author":"Winum","year":"2024"},{"key":"2026090713192588700_cit9","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.biochi.2013.09.028","article-title":"Structural basis for the rational\ndesign of new anti-Brucella\nagents: The crystal structure of the C366S mutant of l-histidinol\ndehydrogenase from Brucella suis","volume":"97","author":"D\u2019Ambrosio","year":"2014","journal-title":"Biochimie"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c01206","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/73\/9\/4977\/68420860\/acs.jafc.5c01206.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/73\/9\/4977\/68420860\/acs.jafc.5c01206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:43:47Z","timestamp":1788803027000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/73\/9\/4977\/3641431\/l-Histidinol-Dehydrogenase-HDH-Represents-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,2,18]]},"published-print":{"date-parts":[[2025,3,5]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c01206","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}