{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:54:32Z","timestamp":1790754872175,"version":"4.1.0"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100020749","name":"Hubei Key Laboratory of Wudang Local Chinese Medicine Research","doi-asserted-by":"publisher","award":["WDCM2024001"],"award-info":[{"award-number":["WDCM2024001"]}],"id":[{"id":"10.13039\/501100020749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB140"],"award-info":[{"award-number":["2024AFB140"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474130"],"award-info":[{"award-number":["82474130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine","award":["KLRCCM2401"],"award-info":[{"award-number":["KLRCCM2401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,9,10]]},"DOI":"10.1021\/acs.jafc.5c02398","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:31:45Z","timestamp":1756315905000},"page":"22778-22793","source":"Crossref","is-referenced-by-count":13,"title":["Pachymic Acid Ameliorates Fructose-Driven Hyperuricemic Nephropathy in Mice by Suppressing Ferroptosis via Activating Nrf2\/GPX-4 Pathway"],"prefix":"10.1021","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2443-2361","authenticated-orcid":true,"given":"Cong","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Basic Medical Science","place":["Yichang, China"]},{"name":"China Three Gorges University","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy","place":["Yichang, China"]},{"name":"China Three Gorges University","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangkun","family":"Xiong","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science","place":["Yichang, China"]},{"name":"China Three Gorges University","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science","place":["Yichang, China"]},{"name":"China Three Gorges University","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3163-292X","authenticated-orcid":true,"given":"Haixia","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science","place":["Yichang, China"]},{"name":"China Three Gorges University","place":["Yichang, China"]},{"name":"Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy","place":["Yichang, China"]},{"name":"China Three Gorges University","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Science","place":["Shiyan, China"]},{"name":"Hubei University of Medicine","place":["Shiyan, China"]},{"name":"Hubei Key Laboratory of Wudang Local Chinese Medicine Research","place":["Shiyan, China"]},{"name":"Hubei University of Medicine","place":["Shiyan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Wuhan, China"]},{"name":"Hubei University of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4476-519X","authenticated-orcid":true,"given":"Xiaochuan","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Wuhan, China"]},{"name":"Hubei University of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2568-8983","authenticated-orcid":true,"given":"Zhenpeng","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Wuhan, China"]},{"name":"Hubei University of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei University of Chinese Medicine","place":["Wuhan, China"]},{"name":"Center of Traditional Chinese Medicine Modernization for Liver Diseases, School of Pharmacy","place":["Wuhan, China"]},{"name":"Hubei University of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Shizhen Laboratory","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00616-6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31694-5"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.08.001"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-69420-5"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad201"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1503155"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1045805"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019101015"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.907209"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176528"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0473"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.02.013"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102303"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05969-9"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00931-8"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02179-w"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/nu16203530"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-018-0783-9"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980021001828"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-00345-8"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118977"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09921-8"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01404-7"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11704"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X23500921"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgab129"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154812"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153552"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpta.2025.100728"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102939"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103360"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3650-4"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2084862"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156084"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.05.034"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040932"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c07795"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050780"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30041-8"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.5942"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.05.020"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2022.tb00207.x"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13040"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102322"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102202"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202794"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109702"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153643"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040393"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.01.026"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05587-5"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.01.012"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.07.026"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44228-5"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2024.0672"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01156-w"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03452-x"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04793-1"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00735-1"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188890"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103179"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3064"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.12090"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-01002-7"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101107"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102525"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.10.323"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade9585"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c02398","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c02398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:13:09Z","timestamp":1757491989000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c02398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":69,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2025,9,10]]}},"alternative-id":["10.1021\/acs.jafc.5c02398"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c02398","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}