{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:16:31Z","timestamp":1791288991387,"version":"4.3.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104400"],"award-info":[{"award-number":["82104400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305087"],"award-info":[{"award-number":["82305087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405524"],"award-info":[{"award-number":["82405524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Henan Province","award":["231111312900"],"award-info":[{"award-number":["231111312900"]}]},{"name":"Key Research and Development Program of Henan Province","award":["232102310505"],"award-info":[{"award-number":["232102310505"]}]},{"name":"Key Research and Development Program of Henan Province","award":["242102310567"],"award-info":[{"award-number":["242102310567"]}]},{"name":"Key Research and Development Program of Henan Province","award":["242102311249"],"award-info":[{"award-number":["242102311249"]}]},{"name":"Key Research and Development Program of Henan Province","award":["242300421519"],"award-info":[{"award-number":["242300421519"]}]},{"name":"Program for Science & Technology Innovation Talents in Universities of Henan Province","award":["23HASTIT044"],"award-info":[{"award-number":["23HASTIT044"]}]},{"name":"Key scientific research projects of colleges and universities in Henan Province","award":["25A360016"],"award-info":[{"award-number":["25A360016"]}]},{"name":"Joint Research Fund of Science and Technology R&D Plan of Henan Province","award":["222301420068"],"award-info":[{"award-number":["222301420068"]}]},{"name":"Joint Research Fund of Science and Technology R&D Plan of Henan Province","award":["232301420085"],"award-info":[{"award-number":["232301420085"]}]},{"name":"Joint Research Fund of Science and Technology R&D Plan of Henan Province","award":["25A350007"],"award-info":[{"award-number":["25A350007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,6,18]]},"DOI":"10.1021\/acs.jafc.5c02433","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T09:05:46Z","timestamp":1749114346000},"page":"15399-15415","source":"Crossref","is-referenced-by-count":7,"title":["Discovery of Atractylenolide Derivatives as Novel LSD1 Inhibitors for the Treatment of Alzheimer\u2019s Disease"],"prefix":"10.1021","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-3664","authenticated-orcid":true,"given":"Zhonghua","family":"Li","sequence":"first","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Lian","family":"Ma","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jige","family":"Yang","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiancheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Han","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Ma","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfang","family":"Su","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Song","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-9198","authenticated-orcid":true,"given":"Xiaofang","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences, Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao","place":["Zhengzhou, China"]},{"name":"Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.320970"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(24)60606-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1020556"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.012"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511974113"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nature04021"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01116-09"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.01.010"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40606-1"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00922-9"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1177\/1179069518765743"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233468"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14912"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1187"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jm400870h"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00114-z"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c03049"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.08.023"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113415"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20220304.701"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1869970"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.865257"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20220706.702"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20211014.201"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2020.104730"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2022.62541.13851"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113778"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111989"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115321"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904395"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230753"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.301"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03388-7"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104895"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1177\/09727531211046369"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00224-5"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.01.002"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116696"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.7150\/thno.57237"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jm401002r"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c02433","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c02433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:15:31Z","timestamp":1750220131000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c02433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":41,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,6,18]]}},"alternative-id":["10.1021\/acs.jafc.5c02433"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c02433","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}