{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:12:47Z","timestamp":1793304767922,"version":"4.5.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"26","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["ZY2023009"],"award-info":[{"award-number":["ZY2023009"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["TGY24H060028"],"award-info":[{"award-number":["TGY24H060028"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,7,2]]},"DOI":"10.1021\/acs.jafc.5c02681","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T10:45:37Z","timestamp":1750761937000},"page":"16557-16572","source":"Crossref","is-referenced-by-count":20,"title":["Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1\/TXNIP Signaling Pathway"],"prefix":"10.1021","volume":"73","author":[{"given":"Sixiang","family":"Feng","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxun","family":"Ma","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixun","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Pan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfan","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikai","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enli","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitian","family":"Bu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Luo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Medical College of Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9114-3504","authenticated-orcid":true,"given":"Jiahao","family":"Tang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9473-8625","authenticated-orcid":true,"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"Zhejiang Key Laboratory of Orthopaedics","place":["Wenzhou, China"]},{"name":"Wenzhou Key Laboratory of Osteoporosis and Elderly Bone Health","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4650-2"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.759843"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00198-w"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30188-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00122"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.69"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106635"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111273"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0212-6"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607769113"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nature16959"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172222"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0573"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106421"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27103292"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020307"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2022.00154"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155658"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.09.028"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155448"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-989-5_22"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00328-y"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111814"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.626621"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.70014"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315123"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101534"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031513"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.131"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802805RR"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c05632"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/biom14070836"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000376r"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-020-01935-w"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.719602"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/foods9091181"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.02.011"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.137591"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c03501"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.08.004"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0257-3"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8151836"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01019-8"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.955128"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2116505119"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000391"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.07.005"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.111862"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050528"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7805115"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300912"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3286928"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102218"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.4161\/chan.3.4.9381"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.02.132"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c02681","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c02681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:11:44Z","timestamp":1751443904000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c02681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":56,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,7,2]]}},"alternative-id":["10.1021\/acs.jafc.5c02681"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c02681","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}