{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:53:28Z","timestamp":1791474808272,"version":"4.3.4"},"reference-count":122,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci?n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci?n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PID2022-138978OB-I00"],"award-info":[{"award-number":["PID2022-138978OB-I00"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog?as","doi-asserted-by":"publisher","award":["861083"],"award-info":[{"award-number":["861083"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/Z51611\/1"],"award-info":[{"award-number":["BB\/Z51611\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,9,10]]},"DOI":"10.1021\/acs.jafc.5c03789","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T20:18:25Z","timestamp":1756153105000},"page":"22877-22894","source":"Crossref","is-referenced-by-count":10,"title":["Antioxidant, Hypotensive, and Antidiabetic Breakthroughs: Bromelain Hydrolysis Unlocks Quinoa\u2019s Peptide Potential -\n                    <i>In Silico<\/i>\n                    and\n                    <i>In Vitro<\/i>\n                    Approach"],"prefix":"10.1021","volume":"73","author":[{"given":"Maria Lilibeth","family":"Manzanilla-Valdez","sequence":"first","affiliation":[{"name":"School of Food Science and Nutrition","place":["Leeds, UK"]},{"name":"University of Leeds","place":["Leeds, UK"]},{"name":"National Alternative Protein Innovation Centre (NAPIC)","place":["Leeds, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioinform\u00e1tica y Simulaci\u00f3n Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas","place":["Culiacan, M\u00e9xico"]},{"name":"Universidad Aut\u00f3noma de Sinaloa","place":["Culiacan, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-6464","authenticated-orcid":true,"given":"Cristina","family":"Martinez-Villaluenga","sequence":"additional","affiliation":[{"name":"Department of Technological Processes and Biotechnology, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jose Antonio Novais 6, Madrid 28040, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3152-3166","authenticated-orcid":true,"given":"Fernanda","family":"Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioinform\u00e1tica y Simulaci\u00f3n Molecular, Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas","place":["Culiacan, M\u00e9xico"]},{"name":"Universidad Aut\u00f3noma de Sinaloa","place":["Culiacan, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-5709","authenticated-orcid":true,"given":"Christine","family":"Boesch","sequence":"additional","affiliation":[{"name":"School of Food Science and Nutrition","place":["Leeds, UK"]},{"name":"University of Leeds","place":["Leeds, UK"]},{"name":"National Alternative Protein Innovation Centre (NAPIC)","place":["Leeds, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-8630","authenticated-orcid":true,"given":"Alan Javier","family":"Hernandez-Alvarez","sequence":"additional","affiliation":[{"name":"School of Food Science and Nutrition","place":["Leeds, UK"]},{"name":"University of Leeds","place":["Leeds, UK"]},{"name":"National Alternative Protein Innovation Centre (NAPIC)","place":["Leeds, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126699"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/foods11091307"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/open.202200017"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073957"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01083"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9090418"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127244"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-019-09899-z"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2024.105925"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-019-09823-5"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-019-09890-8"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04765"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/foods12061327"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2018.03.024"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/976203"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO01060K"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2018.03.006"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1042\/bj1430575"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3844\/ajbbsp.2012.99.104"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2024.101814"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fhfh.2024.100191"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.125161"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1086\/523874"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24244562"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-030222-120000"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-021-00597-z"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijcaap.2022.003"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28237717"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1423"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.129473"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01340"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106245"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2012.07.006"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae236"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/jp973084f"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20482"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.hnm.2022.200164"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.06.024"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.138887"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2021.02.003"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28408-8"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225405"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.04.098"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2016.00656"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113635"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26020430"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c06110"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045012"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2017.1368552"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.85486"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20911"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.02.027"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA05799F"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.121.000461"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00089"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2007.06.005"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-009-8689-6"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.123.001437"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25215073"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(00)00226-X"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.11.064"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2004.11.007"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2022.100880"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113255"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170696"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.14090"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170577"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134434"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01298B"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020378"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1865"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17831"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.465211"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.01.014"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.10.011"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126857"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12451"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00329"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2018.12.015"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.03.095"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009191"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00355-0"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27603"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/372746a0"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2023.1117502"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2022.101355"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.59"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1038\/nature01370"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1021\/cr200246d"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.10.002"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.3390\/cancers6031500"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10579"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01951-9"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-021-09773-1"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13135"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1130625"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1039\/c3fo60262a"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.13061"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13020203"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1002\/med.21986"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21010072"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103698"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-008-0962-3"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.108513"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020505"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2014.05.014"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2013.05.002"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.01.190"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122388"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.3390\/pr10010132"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO05765H"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA04575K"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2018.09.001"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061407"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.3390\/biology12070917"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.113889"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030550"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2023.171046"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.02.037"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c03789","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c03789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:13:26Z","timestamp":1757492006000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c03789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":122,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2025,9,10]]}},"alternative-id":["10.1021\/acs.jafc.5c03789"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c03789","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,25]]}}}