{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:37:17Z","timestamp":1789087037216,"version":"build-2803163510"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100022"],"award-info":[{"award-number":["32100022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QC184"],"award-info":[{"award-number":["ZR2024QC184"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SKLMT Frontiers and Challenges Project","award":["SKLMTFCP-2023-02"],"award-info":[{"award-number":["SKLMTFCP-2023-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,8,13]]},"DOI":"10.1021\/acs.jafc.5c04696","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T08:01:37Z","timestamp":1753948897000},"page":"20450-20461","source":"Crossref","is-referenced-by-count":9,"title":["Loop Dynamics Perturbation Enhances the Catalytic Stability of GH18 Family Chitinases"],"prefix":"10.1021","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1422-4782","authenticated-orcid":true,"given":"Sha","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology","place":["Qingdao, People\u2019s Republic of China"]},{"name":"Shandong University","place":["Qingdao, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoran","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology","place":["Qingdao, People\u2019s Republic of China"]},{"name":"Shandong University","place":["Qingdao, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology","place":["Qingdao, People\u2019s Republic of China"]},{"name":"Shandong University","place":["Qingdao, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8404-0455","authenticated-orcid":true,"given":"Jingyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology","place":["Qingdao, People\u2019s Republic of China"]},{"name":"Shandong University","place":["Qingdao, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-8732","authenticated-orcid":true,"given":"Xukai","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Glycoengineering Research Center","place":["Qingdao, People\u2019s Republic of China"]},{"name":"Shandong University","place":["Qingdao, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-5218","authenticated-orcid":true,"given":"Xiuyun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology","place":["Qingdao, People\u2019s Republic of China"]},{"name":"Shandong University","place":["Qingdao, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8159-6886","authenticated-orcid":true,"given":"Lushan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology","place":["Qingdao, People\u2019s Republic of China"]},{"name":"Shandong University","place":["Qingdao, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2020.06.001"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-020-03416-5"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2023.102980"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/polym13183048"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.04.100"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh8615"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123440"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-12067-x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06328-6"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-023-00495-w"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2020.12.007"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/gcbb.13011"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45662-9"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132083"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.04.012"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-015-2696-z"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1110\/ps.037473.108"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22946"},{"key":"ref19\/cit19","first-page":"605","volume":"281","author":"Altundag M.","year":"2014","journal-title":"Febs J."},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.05.014"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2017.07.003"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzr051"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.2889"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/cr2003773"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2013.04.004"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-023-02411-2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.04.118"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2020.107553"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-019-1472-1"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/genomea.00780-16"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.3c00936"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msy096"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1298"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ja955032e"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/jp401410h"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c01466"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6472-7_25"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1042\/bj2530677"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138130"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2021.114394"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.11.178"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s002530000327"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1177\/1087057109355057"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-22110-1_47"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-016-1596-7"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(91)90543-9"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1042\/bj2430779"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/bi010505h"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-019-1472-1"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1186\/s40643-022-00543-1"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvh105"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103610200"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)01036-7"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2019.1682963"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c01303"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-023-02411-2"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26030707"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1970508"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.1c10605"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81497-N"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/13.9.655"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134953"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.2c04531"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2021.109803"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1109\/ciis.2017.34"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000935"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/cryst12091228"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.646182"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2016.09.014"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c00260"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.136241"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c04696","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c04696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T08:12:04Z","timestamp":1755072724000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c04696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":71,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,8,13]]}},"alternative-id":["10.1021\/acs.jafc.5c04696"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c04696","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}