{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:22:55Z","timestamp":1788445375703,"version":"build-2803163510"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002365","name":"China Agricultural University","doi-asserted-by":"publisher","award":["2115 Talent Development Program"],"award-info":[{"award-number":["2115 Talent Development Program"]}],"id":[{"id":"10.13039\/501100002365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,9,3]]},"DOI":"10.1021\/acs.jafc.5c05681","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T04:10:20Z","timestamp":1755922220000},"page":"22070-22078","source":"Crossref","is-referenced-by-count":2,"title":["Saccharin Supplementation Aggravates High-Fat-Diet-Induced Atherosclerosis through Lipid Metabolism Disorder and Intestinal-Impairment-Induced Endothelial Dysfunction in <i>ApoE<\/i><sup>\u2013\/\u2013<\/sup> Mice"],"prefix":"10.1021","volume":"73","author":[{"given":"Yuxin","family":"Li","sequence":"first","affiliation":[{"name":"College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Food Quality and Safety, Department of Nutrition and Health","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingting","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7758-5161","authenticated-orcid":true,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]},{"name":"Beijing Laboratory of Food Quality and Safety, Department of Nutrition and Health","place":["Beijing, China"]},{"name":"China Agricultural University","place":["Beijing, China"]},{"name":"Food Laboratory of Zhongyuan","place":["Luohe, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.308903"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001303"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.04.004"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad304"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233843"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129179"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.85936"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-071204"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.161390"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmaa084"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.01.006"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113984"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.261"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-9002"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuw032"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15709"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nature13793"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.04.045"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO00883C"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-011-1009-3"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-014-9273-z"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1080\/14017431.2023.2205068"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033714"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040855"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/nu14081682"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000201071.49029.17"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.730525"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.08.004"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00465-2"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7502"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030718"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2001"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-019-10142-4"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0257-3"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1806939"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093131"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019645"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i11.3117"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2021.08.015"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00675-x"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-00960-y"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c05681","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c05681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T08:11:27Z","timestamp":1756887087000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c05681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":43,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2025,9,3]]}},"alternative-id":["10.1021\/acs.jafc.5c05681"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c05681","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]}}}