{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:23:27Z","timestamp":1790274207350,"version":"4.1.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","award":["2023SK4001"],"award-info":[{"award-number":["2023SK4001"]}],"id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Cultivation Base for Postgraduates' Top Innovative Talents in Hunan Province","award":["372"],"award-info":[{"award-number":["372"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2026,2,11]]},"DOI":"10.1021\/acs.jafc.5c08111","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:41:01Z","timestamp":1769550061000},"page":"4363-4376","source":"Crossref","is-referenced-by-count":4,"title":["Mulberry Leaf Alkaloids and Their Main Component 1-Deoxynojirimycin Mitigate CDAHFD-Induced Metabolic Dysfunction-Associated Steatohepatitis by Promoting Autophagy through the PI3K\/AKT\/mTOR Pathway"],"prefix":"10.1021","volume":"74","author":[{"given":"Chen","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyan","family":"Liao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-0523","authenticated-orcid":true,"given":"Qiuxian","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-01084-2"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.03.011"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.038"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/biom14040476"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.02.003"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/nu16223789"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065465"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/cells14060428"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-016-2272-8"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.4103\/2225-4110.131639"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00313-20"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1989660"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115026"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/jf073223i"},{"key":"ref15\/cit15","author":"He W.","year":"2016","journal-title":"inXinjiang Province"},{"issue":"07","key":"ref16\/cit16","first-page":"146","volume":"41","author":"Zuwen W.","year":"2020","journal-title":"Food Science"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.11.005"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000639"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02108-x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14010056"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-019-10257-8"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.100973"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13060729"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000786"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00845-0"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-01003-6"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70145"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176644"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122860"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105238"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.05.121"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO02324A"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/jf010567e"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI164660"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114713"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21030279"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2020.07.048"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109808"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10040595"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.072"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109895"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109184"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116523"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114005"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b01766"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jf903132r"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c08111","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c08111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T09:13:26Z","timestamp":1770801206000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c08111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,2,11]]}},"alternative-id":["10.1021\/acs.jafc.5c08111"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c08111","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}