{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:20:48Z","timestamp":1784892048684,"version":"3.55.0"},"reference-count":77,"publisher":"American Chemical Society (ACS)","issue":"51","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750672"],"award-info":[{"award-number":["2024M750672"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2024-BS-090"],"award-info":[{"award-number":["2024-BS-090"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172454"],"award-info":[{"award-number":["32172454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2025,12,24]]},"DOI":"10.1021\/acs.jafc.5c08824","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T18:57:16Z","timestamp":1765825036000},"page":"32544-32558","source":"Crossref","is-referenced-by-count":1,"title":["Design and Synthesis of a Novel Guanidino-Modified Nucleoside and Its Antiviral Activity against Potato Virus Y"],"prefix":"10.1021","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8494-1987","authenticated-orcid":true,"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Liaoning Key Laboratory of Plant Pathology, College of Plant Protection","place":["Shenyang, China"]},{"name":"Shenyang Agricultural University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-8592","authenticated-orcid":true,"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Plant Pathology, College of Plant Protection","place":["Shenyang, China"]},{"name":"Shenyang Agricultural University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Plant Pathology, College of Plant Protection","place":["Shenyang, China"]},{"name":"Shenyang Agricultural University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"An","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Plant Pathology, College of Plant Protection","place":["Shenyang, China"]},{"name":"Shenyang Agricultural University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Liu","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Plant Pathology, College of Plant Protection","place":["Shenyang, China"]},{"name":"Shenyang Agricultural University","place":["Shenyang, China"]},{"name":"National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals","place":["Guiyang, China"]},{"name":"Guizhou University","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-8679","authenticated-orcid":true,"given":"Yuanhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Plant Pathology, College of Plant Protection","place":["Shenyang, China"]},{"name":"Shenyang Agricultural University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-022-01767-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1232279"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2011.00752.x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800468105"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-007-1059-1"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1094\/PD-90-1102"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0434.2007.01377.x"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13084"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2022.198948"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2022.10.005"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2018.09.007"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/v7122935"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2012.07.010"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO-08-19-0307-FI"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-12-3141"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/v10100568"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.07.008"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1318"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2019.197827"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/ps.7700"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB00169B"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00105-9"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.41.1711"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/BF00265072"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2014.04.008"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b02662"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.10.017"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2022.2039620"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01654-08"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.11.013"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00075-20"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3660"},{"key":"ref33\/cit33","first-page":"2467","volume":"17","author":"Ceylan B.","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014962.pub2"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00570-1"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2010.08.003"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1560"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg203"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2015.1058357"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2022.102873"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1517\/13543770903216675"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB02240B"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/ol006322p"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/c2np20071f"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1185\/030079904125003278"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12697"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133432"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02106-06"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098280"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbt.2016.01.001"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/ps.7147"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c02767"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.051"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.5423\/PPJ.OA.07.2024.0103"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065477"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2022.198779"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.03.023"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2018.12.012"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2017.03.001"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-011-1062-4"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b04136"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201801317"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202200144"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113135"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1039\/D4NJ00228H"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.3c03311"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305574101"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-023-03101-x"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2019.02.018"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147718"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2404887121"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/ssq073"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147718"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2019.09.024"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c08824","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c08824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:42:26Z","timestamp":1768567346000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c08824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":77,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2025,12,24]]}},"alternative-id":["10.1021\/acs.jafc.5c08824"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c08824","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}