{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:15:13Z","timestamp":1788455713985,"version":"build-2803163510"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["PR-KL2022GY005"],"award-info":[{"award-number":["PR-KL2022GY005"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012397","name":"Army Medical University","doi-asserted-by":"publisher","award":["2023XQN17"],"award-info":[{"award-number":["2023XQN17"]}],"id":[{"id":"10.13039\/501100012397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigated how the prebiotic inulin protects against heat-stroke-induced intestinal barrier damage. A classic\/passive heat-stroke model was established in C57BL\/6J mice. After 4 weeks of dietary intervention with 5% inulin, gut microbiota, fecal short-chain fatty acids, intestinal barrier function, and signaling pathways were examined using 16S rRNA sequencing, gas chromatography\u2013mass spectrometry, Western blotting, and cell models. Inulin decreased the core body temperature and mortality, reshaped the gut microbiota, and increased Bifidobacterium abundance and fecal butyrate. Butyrate activated G protein-coupled receptor 43 (GPR43) and upregulated the tight junction proteins zonula occludens-1 and occludin through protein kinase C-cAMP response element-binding protein signaling, thereby improving barrier integrity and reducing systemic inflammation. These findings indicate that inulin protects against heat stroke through the gut microbiota-butyrate-GPR43 axis and may offer a nutritional intervention strategy.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c13669","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:01:28Z","timestamp":1787155288000},"page":"27025-27041","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Study\nof Inulin in Ameliorating Heat Stroke-Induced\nIntestinal Barrier Damage via Modulation of Gut Microbiota- Butyrate\u2013GPR43\nAxis"],"prefix":"10.1021","volume":"74","author":[{"given":"Zhen","family":"Luo","sequence":"first","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]},{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeze","family":"Wang","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]},{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Tan","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]},{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genlin","family":"He","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]},{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]},{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]},{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Shen","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Liu","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-0093","authenticated-orcid":true,"given":"Xue","family":"Luo","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]},{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesen","family":"Yang","sequence":"additional","affiliation":[{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]},{"name":"Army Medical University , , ,","place":["Chongqing, China, 400038"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"10419","key":"2026090311501605700_cit1","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1016\/S0140-6736(23)01859-7","article-title":"The 2023 report of the Countdown on health\nand climate change: the imperative for a health-centred response in\na world facing irreversible harms","volume":"402","author":"Romanello","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"2026090311501605700_cit2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-021-00334-6","article-title":"Classic and exertional heatstroke","volume":"8","author":"Bouchama","year":"2022","journal-title":"Nat. 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Microbiol."},{"key":"2026090311501605700_cit26","doi-asserted-by":"publisher","first-page":"979","DOI":"10.3389\/fmicb.2016.00979","article-title":"Bifidobacteria\nand Butyrate-Producing Colon Bacteria: Importance and Strategies for\nTheir Stimulation in the Human Gut","volume":"7","author":"Rivie\u0300re","year":"2016","journal-title":"Front. 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Microbiol."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c13669","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/34\/27025\/66882088\/acs.jafc.5c13669.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/34\/27025\/66882088\/acs.jafc.5c13669.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:21:44Z","timestamp":1788452504000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/34\/27025\/5276894\/Mechanistic-Study-of-Inulin-in-Ameliorating-Heat"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":34,"journal-issue":{"issue":"34","published-online":{"date-parts":[[2026,8,19]]},"published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c13669","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]}}}