{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:56:40Z","timestamp":1791388600871,"version":"4.3.3"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Jilin Provincial Scientific and Technological Development Scheme","award":["YDZJ202401004ZYTS"],"award-info":[{"award-number":["YDZJ202401004ZYTS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Auraptene (AP), a coumarin derivative abundant in citrus peels, exhibits diverse bioactivities; however, its role in acute liver injury and the underlying mechanisms remain elusive. This study investigates the hepatoprotective effects of AP against carbon tetrachloride (CCl4)-induced acute liver injury in mice and explored its mechanistic basis. In vitro, transforming growth factor-beta (TGF-\u03b2) was employed to stimulate AML-12 hepatocytes to model the injury microenvironment. The impact of AP on the toll-like receptor 2 (TLR2) signaling pathway was assessed through a combination of siRNA gene silencing and signal pathway inhibitors. AP pretreatment significantly decreased the expression of liver injury markers. Additionally, AP can reduce inflammatory (Caspase-1, gasdermin D (GSDMD), interleukin (IL)-1\u03b2, IL-18), as well as apoptosis factors (Caspase-3, Caspase-8, P53). Gene silencing experiment confirmed that AP\u2019s anti-inflammatory and antiapoptosis effects depended on the TLR2 signaling pathway. These findings indicate that AP, a food-derived bioactive compound from citrus fruits, effectively mitigates CCl4-provoked acute hepatic injury.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c13753","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:01:22Z","timestamp":1790460082000},"page":"30707-30721","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Supplementation\nof Auraptene, a Major Component\nin\n                    <i>Citrus reticulata<\/i>\n                    Blanco, Prevents\nAcute Liver Injury Associated with Apoptosis and Inflammation"],"prefix":"10.1021","volume":"74","author":[{"given":"Tao","family":"Guo","sequence":"first","affiliation":[{"name":"Beihua University , , , ,","place":["Jilin, Jilin Province, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Jilin Agricultural University , , , ,","place":["Changchun, Jilin Province, China, 130118"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Beihua University , , , ,","place":["Jilin, Jilin Province, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Feng","family":"Jia","sequence":"additional","affiliation":[{"name":"Beihua University , , , ,","place":["Jilin, Jilin Province, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yu","family":"Lv","sequence":"additional","affiliation":[{"name":"Beihua University , , , ,","place":["Jilin, Jilin Province, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University , , , ,","place":["Guangdong, Guandong Province, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-1074","authenticated-orcid":true,"given":"Jing-Bo","family":"Sun","sequence":"additional","affiliation":[{"name":"Beihua University , , , ,","place":["Jilin, Jilin Province, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"issue":"14","key":"2026100711071658000_cit1","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1080\/10408398.2021.1969891","article-title":"Nutrients and bioactives in citrus\nfruits: Different citrus varieties, fruit parts, and growth stages","volume":"63","author":"Lu","year":"2023","journal-title":"Crit. 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