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In the current study, the induction of ferroptosis was first determined by assessments of cell viability, mitochondrial phenotypes, Fe2+ content, and lipid peroxidation levels in NRK-52E and 293T cells. At both mRNA and protein expression levels, OTA exposure resulted in an increase in DMT1 levels. Interestingly, lysosomes were found to colocalize with Fe2+ upon exposure to OTA. Lysosome inhibitor BafA1 reduced OTA-induced ferroptosis and activation of DMT1 and FTH. Additionally, OTA treatment resulted in the rapid movement of DMT1 to lysosomes by quantifying the colocalization of pEGFP-N1-DMT1 and lysosome tracker. Silencing of DMT1 reversed OTA-induced cell death and lipid peroxidation. Collectively, this study elucidates the critical role of lysosome-dependent DMT1 in the ferroptosis of renal cells induced by OTA, offering a comprehensive strategy for mitigating the OTA-induced nephrotoxicity.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c14984","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T21:01:39Z","timestamp":1786914099000},"page":"26640-26654","source":"Crossref","is-referenced-by-count":0,"title":["Lysosome DMT1-Mediated\nRenal Cell Ferroptosis Induced\nby Ochratoxin A"],"prefix":"10.1021","volume":"74","author":[{"given":"Qian","family":"Lin","sequence":"first","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongle","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Tan","sequence":"additional","affiliation":[{"name":"Lunan Pharmaceutical Group Co., Ltd. , , , ,","place":["Linyi, Shandong Province, PR China, 276003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Famous","family":"Erhunmwunsee","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhida","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Fan","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Ren","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Peng","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tian","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-7697","authenticated-orcid":true,"given":"Man","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , , ,","place":["Xuzhou, Jiangsu Province, PR China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"issue":"10","key":"2026090104481913400_cit1","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1007\/s00204-024-03805-3","article-title":"Central role of Sigma-1 receptor\nin ochratoxin A-induced ferroptosis","volume":"98","author":"Chen","year":"2024","journal-title":"Arch. 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